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Last update 06 Dec 2025
EX-103
Last update 06 Dec 2025
Overview
Basic Info
Drug Type Bispecific T-cell Engager (BiTE) |
Synonyms Anti-CD3/anti-CD20 bispecific T-cell engager, EX 103, EX103 |
Target |
Action inhibitors, stimulants |
Mechanism CD20 inhibitors(B-lymphocyte antigen CD20 inhibitors), CD3 stimulants(T cell surface glycoprotein CD3 stimulants) |
Therapeutic Areas |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
Regulation- |
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Related
1
Clinical Trials associated with EX-103NCT06021678
A Phase I/II Study Evaluating the Safety, Efficacy, and Pharmacokinetics of EX103 in Subjects with Relapsed/Refractory CD20-Positive Non-Hodgkin Lymphoma
100 Clinical Results associated with EX-103
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100 Translational Medicine associated with EX-103
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100 Patents (Medical) associated with EX-103
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100 Deals associated with EX-103
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| CD20 positive Non-Hodgkin Lymphoma | Phase 2 | China | 25 Oct 2021 | |
| Chronic Lymphocytic Leukemia | Phase 1 | United States | 30 Jan 2022 | |
| Chronic Lymphocytic Leukemia | Phase 1 | China | 30 Jan 2022 | |
| Non-Hodgkin Lymphoma | Phase 1 | United States | 30 Jan 2022 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1/2 | - | tmslolnela(amxbzclasu) = CRS events were the most common treatment related adverse events and occurred in 66.7% of the patients, with 50.7% grade 1, 14.5% grade 2, one patient (1.4%) experienced grade 3, and no higher events occurred. muhcxawtpy (gdjbvicfpf ) View more | - | 08 Dec 2024 | |||
Phase 1/2 | 23 | krxniblbfm(ceorgjqmxy) = All CRS events were grade (Gr) 1-2 (Gr 1: 78.3%, Gr 2: 13.0%), no Gr 3 or higher events ghmsbwsbrt (ovipxyegau ) View more | Positive | 24 May 2024 | |||
Phase 1 | 13 | xtgenepwjm(jqbjxbmryk) = The most common adverse events were CRS and pyrexia, all were grade (Gr) 1-2, no Gr 3 or higher. Most CRS occurred in 1st or 2nd cycle, and resolved within 48 hours. No neurologic AE occurred. snkuwnzyqa (tiappcweiz ) | Positive | 23 Oct 2023 | |||
(DLBCL patients) |
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Biosimilar
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Regulation
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