Last update 11 Jul 2024

EX-103

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms
Anti-CD3/anti-CD20 bispecific T-cell engager
Mechanism
CD20 inhibitors(B-lymphocyte antigen CD20 inhibitors), CD3 stimulants(T cell surface glycoprotein CD3 stimulants)
Inactive Indication-
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
CD20 positive Non-Hodgkin LymphomaPhase 2
CN
25 Oct 2021
Chronic Lymphocytic LeukemiaPhase 1
CN
30 Jan 2022
Chronic Lymphocytic LeukemiaPhase 1
US
30 Jan 2022
Non-Hodgkin LymphomaPhase 1
US
30 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
ESMO2023
ManualManual
Phase 1
13
(iqtdetggdj) = The most common adverse events were CRS and pyrexia, all were grade (Gr) 1-2, no Gr 3 or higher. Most CRS occurred in 1st or 2nd cycle, and resolved within 48 hours. No neurologic AE occurred. ieanjfpmun (mtrdgcixeg )
Positive
23 Oct 2023
(DLBCL patients)
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Regulation

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