Last update 06 Nov 2024

N-acetyl-D-mannosamine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-Actamido-2-deoxy-D-mannose, D-ManNAc, LB-301 - Leadiant Biosciences
+ [7]
Target-
Mechanism
Glycosylation stimulants, Proteins modulators
Inactive Indication-
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Structure

Molecular FormulaC8H15NO6
InChIKeyMBLBDJOUHNCFQT-WCTZXXKLSA-N
CAS Registry3615-17-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Distal MyopathiesPhase 3--
Distal MyopathiesPhase 3--
Glomerulosclerosis, Focal SegmentalPhase 2
US
11 Nov 2024
Distal Myopathy, Nonaka TypePhase 2
US
05 Feb 2015
Kidney DiseasesPhase 1
US
07 Jul 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
12
edacwxsxgu(ibxdahxoxf) = upffgsnrjv azrsdbcvky (jyqbetngkg )
Positive
01 Nov 2021
Phase 1
7
ManNAc 3g single dose
tgluqmcfkg(veslnvqrfs) = There were no serious adverse events. Most subjects (5 of 6) that received ManNAc twice daily showed a marked reduction in urine PCR (26-54%), which correlated with the degree of glomerular hyposialylation sbqhubvomy (zfdiiktqiv )
Positive
19 Oct 2020
Phase 2
12
(ManNAc: Cohort A)
ltgbhpeyyk(ctqudvndhn) = mqhjgkmvkh sxrgifndlo (engvzfcxag, dljrodsopm - yyfzolghds)
-
16 Apr 2019
(ManNAc: Cohort B)
ltgbhpeyyk(ctqudvndhn) = qjgbbwxwaa sxrgifndlo (engvzfcxag, pxilklqrkm - sjabhvfmrh)
Not Applicable
Nephrosis, Lipoid
Angptl4 | NPHS2-Angptl4 | PAN
-
arahbqbles(qhbsoeizca) = puvfhzseiz qvkrqgwext (zefidvtken )
Positive
16 Nov 2010
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Regulation

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