Last update 20 Jun 2026

Midazolam/Ketamine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
MELT-100, MELT-300
Action
agonists
Mechanism
GABAA receptor agonists(Gamma-aminobutyric acid A receptor agonists), NMDA receptor agonists(Glutamate [NMDA] receptor agonists)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC18H13ClFN3
InChIKeyDDLIGBOFAVUZHB-UHFFFAOYSA-N
CAS Registry59467-70-8
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
CataractPhase 3
United States
01 May 2024
SedationPhase 2
United States
20 Jul 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
hiossiyurx(lpmcjebepr) = Proportion of Patients Requiring Rescue Sedation Was Nearly Two-Fold Higher for Sublingual Midazolam Compared with MELT-300 (P=0.003). MELT-300 Had a Favorable Safety Profile That Was Generally Comparable to Placebo. uktgrpmtbq (mfslbbqnyi )
Superior
20 Nov 2024
Phase 2
-
xqqwvvifns(zpvmwqdgkp) = MELT-300 achieved the primary sedation endpoint in its Phase 2 Pivotal Efficacy and Safety Study in subjects undergoing cataract surgery. maqnmkommp (vtpcqphxyz )
Positive
03 Jan 2024
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Clinical Trial

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Approval

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Regulation

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