Last update 12 Jul 2024

2X-121

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Stenoparib, 2X-121/PARPI, E-7449
+ [2]
Mechanism
PARP1 inhibitors(Poly (ADP-Ribose) polymerase 1 inhibitors), PARP2 inhibitors(Poly (ADP-Ribose) Polymerase 2 inhibitors), TNKS1 inhibitors(tankyrase inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-

Structure

Molecular FormulaC18H15N5O
InChIKeyJLFSBHQQXIAQEC-UHFFFAOYSA-N
CAS Registry1140964-99-3

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Ovarian CancerPhase 2
GB
09 Apr 2019
Breast CancerPhase 2
DK
20 Jun 2018
Metastatic breast cancerPhase 2
DK
20 Jun 2018
Chronic Lymphocytic LeukemiaPhase 2
GB
01 Jan 2012
MelanomaPhase 2
GB
01 Jan 2012
Triple Negative Breast CancerPhase 2
GB
01 Jan 2012
B-Cell LymphomaPhase 2
GB
-
Advanced Malignant Solid NeoplasmPhase 1
US
20 Feb 2023
COVID-19Preclinical
US
27 May 2020
SarcomaPreclinical
US
21 Oct 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
41
azgjdszimy(jizzrorvej) = fatigue, n = 4, 800 mg; anaphylaxis, n = 1, 600 mg qdyoolygjk (tprjdtcpbh )
-
11 Jun 2020
Phase 1
25
huciimbsnj(jzivlrixmk) = inpqasozjg dlokdhrxnx (awgnaylced )
-
20 May 2014
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Approval

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Regulation

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