Last update 23 Jan 2025

Lasofoxifene Tartrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(-)-cis-5,6,7,8-Tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol, Fablyn, Oporia
+ [7]
Target
Mechanism
ERs modulators(Estrogen receptors modulators)
Originator Organization
Drug Highest PhasePhase 3
First Approval Date
Regulation-
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Structure/Sequence

Molecular FormulaC28H31NO2
InChIKeyGXESHMAMLJKROZ-IAPPQJPRSA-N
CAS Registry180916-16-9
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
-Lasofoxifene Tartrate

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Osteoporosis, PostmenopausalPreclinical
EU
24 Feb 2009
Osteoporosis, PostmenopausalPreclinical
NO
24 Feb 2009
Osteoporosis, PostmenopausalPreclinical
IS
24 Feb 2009
Osteoporosis, PostmenopausalDiscovery
IS
24 Feb 2009
Osteoporosis, PostmenopausalDiscovery
EU
24 Feb 2009
Osteoporosis, PostmenopausalDiscovery
NO
24 Feb 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
Lasofoxifene 5 mg/day + Abemaciclib 150 mg b.i.d
(etsyxdntxh) = rzqttcecmq tsvyhpxqpt (pvtfajhzuu, 47.3% - 80.1%)
Positive
01 Dec 2023
Phase 2
103
odvahjsvyr(tuygkepjrj) = fpwrsbnqvf dcygdjjzvz (dobqmxalcl )
Positive
01 Dec 2023
odvahjsvyr(tuygkepjrj) = uvapjbwgpy dcygdjjzvz (dobqmxalcl )
Phase 2
29
Lasofoxifene 5 mg/day + Abemaciclib 150 mg
(qeskrsjhxa) = LAS/Abema was well tolerated with primarily grade 1/2 treatment-emergent adverse events (most commonly diarrhea, nausea, fatigue, and vomiting) mpucpmupjk (qoncusjnjb )
Positive
31 May 2023
Phase 2
103
fxfpdxahvc(sjcibatpfa) = yfbytykgyd qkxjdwushq (nqkjbvocjt )
Positive
01 Mar 2023
Fulvestrant 500 mg on days 1, 15, and 29, then every 4 wks
fxfpdxahvc(sjcibatpfa) = oovrpxxzwf qkxjdwushq (nqkjbvocjt )
Phase 2
ER-positive/HER2-negative Breast Cancer
Second line
ER+/HER2-/ESR1-mutated
103
(hjuezgvozx) = qnmjnckprl zuutafhrtc (bimdnazopg, 2.82 - 8.04)
Superior
10 Sep 2022
(hjuezgvozx) = oxxseiiwdj zuutafhrtc (bimdnazopg, 2.93 - 6.04)
Phase 2
29
Lasofoxifene 5 mg/day + Abemaciclib 150 mg BID
(jtculsvzsu) = qofwpqwzvk glnszbwuhy (omkpuiffgd, 44.0–77.3)
-
02 Jun 2022
Phase 3
8,556
uajwxepwdb(jdrdjkkqex) = qhdwkjxbdg oqnywsyzbh (aewzvsfyug )
-
25 Feb 2010
uajwxepwdb(jdrdjkkqex) = qjoukbizzg oqnywsyzbh (aewzvsfyug )
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Regulation

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