Last update 01 Nov 2024

PEN-866

Overview

Basic Info

Drug Type
Small molecule-drug conjugates
Synonyms
Hsp90-targeted sn-38 conjugate pen-866, Locnartecan
+ [4]
Mechanism
HSP90 inhibitors(Heat shock 90kDa proteins inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC49H49N7O9
InChIKeyQTPZAEAYDWMVJO-GGCSAXROSA-N
CAS Registry1472614-83-7
View All Structures (2)
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External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cervical Squamous Cell CarcinomaPhase 2
US
29 Aug 2017
Gastroesophageal junction adenocarcinomaPhase 2
US
29 Aug 2017
Small Cell Lung CancerPhase 2
US
29 Aug 2017
Squamous cell carcinoma of vulvaPhase 2
US
29 Aug 2017
stomach adenocarcinomaPhase 2
US
29 Aug 2017
uterus adenocarcinomaPhase 2
US
29 Aug 2017
Advanced cancerPhase 1
US
29 Aug 2017
Advanced Malignant Solid NeoplasmPhase 1
US
29 Aug 2017
squamous cell carcinoma of the anusPhase 1
US
29 Aug 2017
Pancreatic Ductal AdenocarcinomaPreclinical
US
29 Aug 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
21
(lqaltrkmhf) = tgbnyrdriu epauotihsq (pwlommcchx )
-
28 Sep 2019
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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