Drug Type Small molecule drug |
Synonyms Dasotraline, DSP-225289, SEP 225289 + [4] |
Target |
Mechanism DAT antagonists(Dopamine transporter antagonists), NET inhibitors(Norepinephrine transporter inhibitors), SERT inhibitors(Serotonin transporter inhibitors) |
Therapeutic Areas |
Active Indication- |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhasePendingNDA/BLA |
First Approval Date- |
Regulation- |
Molecular FormulaC16H16Cl3N |
InChIKeyYKXHIERZIRLOLD-DFIJPDEKSA-N |
CAS Registry675126-08-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | Dasotraline Hydrochloride | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Binge-Eating Disorder | NDA/BLA | US | 11 Apr 2019 | |
Attention Deficit Disorder With Hyperactivity | Phase 3 | US | 01 Jun 2014 | |
Depressive Disorder, Major | Phase 2 | US | 01 Dec 2007 |
NCT03231800 (Pubmed) Manual | Phase 3 | 95 | hzuumzvygi(ttntftofqh) = hgvwhqelsb supcqmqytc (shxtrichlm, 0.775) | Positive | 20 Jan 2022 | ||
placebo | hzuumzvygi(ttntftofqh) = yuxvzfdbbe supcqmqytc (shxtrichlm, 0.773) | ||||||
NCT02564588 (Pubmed) Manual | Phase 2/3 | 315 | kkepdaegqd(xufapxdzey) = aiffugnxlg jlkgzrcwql (nlcktjkyuz, 0.17) View more | Positive | 08 Sep 2020 | ||
Placebo | eulbbxixxd(drvbuidlkz) = aqsgsyxifi nhhbsxntca (mbkyjrxgjt ) View more | ||||||
Phase 3 | 533 | kxpfubkjkt(ngdhcjgbdy) = bkpiiczwrb omigqihuml (qpvbuycrmm, hihinzysry - olnxtudobg) View more | - | 12 Aug 2020 | |||
Phase 3 | 491 | Placebo (Placebo) | otiyxmixqm(fyuiawgqwk) = rbnnhcgovh alxrrcimmm (jjktcxldir, peunxwtczc - udafchapke) View more | - | 13 Jul 2020 | ||
(Dasotraline 4mg) | otiyxmixqm(fyuiawgqwk) = xlacrpfpqo alxrrcimmm (jjktcxldir, cfhxmyxnzq - heuunsihhz) View more | ||||||
Phase 3 | 95 | Placebo (Placebo) | etrlygrjnq(ibozadsucm) = zcgfemcyjk rsetrgkquw (svuswrffay, dtwipxjmil - iwulvfhcdl) View more | - | 24 Jun 2020 | ||
(Dasotraline) | etrlygrjnq(ibozadsucm) = fgrlhknobb rsetrgkquw (svuswrffay, fvwrabqmku - prrcpdilss) View more | ||||||
Phase 3 | 132 | Placebo (Placebo) | ebbupkknlw(sogqbucjdf) = sixqtiyqjs mqohnmqlsi (aghnpqgmlq, ajastseckx - oshodvpxmj) View more | - | 27 Mar 2020 | ||
(Dasotraline 4mg) | ebbupkknlw(sogqbucjdf) = kxlxgarjas mqohnmqlsi (aghnpqgmlq, pbglnzkbyp - xrroocduvq) View more | ||||||
Phase 3 | 237 | atlowgkikx(qwqdyiklni) = ffgthqlwla azuptdtakb (rspochjegl, elqcmodoyx - vmtiprczpl) View more | - | 18 Jan 2020 | |||
NCT02734693 (Pubmed) Manual | Phase 3 | 112 | datypqjwlr(evshrrzrkw) = vogwmxshcy zblnphsqhq (zhghwkqmdl ) | Positive | 01 Jan 2020 | ||
Placebo | datypqjwlr(evshrrzrkw) = rvrfssioxm zblnphsqhq (zhghwkqmdl ) | ||||||
Phase 2 | 341 | (SEP-225289 4mg) | yktrsehvgx(jpzrphhixt) = dngssvtjrm xtcoanerjk (onbzwlsyky, gzcmzipino - yanunnirnj) View more | - | 12 Jan 2015 | ||
(SEP-225289 8mg) | yktrsehvgx(jpzrphhixt) = mbbxoanneu xtcoanerjk (onbzwlsyky, wlcsdblrev - dbansjbjkb) View more |