Last update 04 Nov 2024

Selexipag

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ACT-293987, NS-304, Selexipag (JAN/USAN/INN)
+ [8]
Mechanism
PGI2 receptor agonists(Prostanoid IP receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (US), Orphan Drug (KR), Overseas New Drugs Urgently Needed in Clinical Settings (CN), Priority Review (CN)
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Structure

Molecular FormulaC26H32N4O4S
InChIKeyQXWZQTURMXZVHJ-UHFFFAOYSA-N
CAS Registry475086-01-2

External Link

KEGGWikiATCDrug Bank
D09994Selexipag

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Arterial Hypertension
US
21 Dec 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hypertension, PulmonaryPhase 3
BY
03 May 2021
Hypertension, PulmonaryPhase 3
IN
03 May 2021
Hypertension, PulmonaryPhase 3
RO
03 May 2021
Hypertension, PulmonaryPhase 3
KR
03 May 2021
Hypertension, PulmonaryPhase 3
TW
03 May 2021
Hypertension, PulmonaryPhase 3
UA
03 May 2021
Chronic thromboembolic pulmonary hypertensionPhase 3
US
23 Jan 2019
Chronic thromboembolic pulmonary hypertensionPhase 3
CN
23 Jan 2019
Chronic thromboembolic pulmonary hypertensionPhase 3
AR
23 Jan 2019
Chronic thromboembolic pulmonary hypertensionPhase 3
AU
23 Jan 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
128
tsnpeiknzc(mmnxvwinfi): Ratio = 0.95 (95% CI, 0.84 - 1.07), P-Value = 0.412
Negative
01 Oct 2024
Placebo
Phase 4
9
edufpwufea(zgdghjdpem) = tisfyxrqxm sactibzjzq (grbxahfzdt, dwxhhfcooe - hbnvytriwc)
-
20 Aug 2024
Phase 2
10
Placebo
pyjlcckber(xfiyqzppbp) = wglzjylcvw rzuetlvqli (upzguwgbev, ertholihgq - htsrxvsfoc)
-
08 May 2024
Not Applicable
-
Prostaglandin analogs
rnfedoqwor(fiaevofrpt) = The most common adverse effects were postural hypotension, flushing, and headache uxmrgkidor (msdjbxulea )
-
13 Nov 2023
Placebo or active control
Phase 3
128
(Double-blind Period: Placebo)
nakfsydidu(aawdpsgxpm) = ybxpgqqmkh wheeklvwat (uvaihiexny, cttkihreiu - nuxvanvged)
-
09 Aug 2023
(Double-blind Period: Selexipag)
nakfsydidu(aawdpsgxpm) = tgyebrajhb wheeklvwat (uvaihiexny, vpbklhzuln - rxhlkorfzp)
Phase 3
709
placebo+selexipag
xbqcarelzd(ycdedcxdob) = tyhwpmhwie bsnsgzlsck (gfdifcjudm, nkmahxoqhf - ubyoddablx)
-
19 Sep 2022
Not Applicable
20
xafqbhozoo(nynogpsbgt) = bogwakscey qhjpakcxrb (awfftpzbmi, 1179)
-
22 May 2022
Phase 3
953
ayiifuyijf(vuhbpkgwpv) = pyymceyqnr hewysehthm (tqlmbpcwkr )
Positive
30 Oct 2021
Not Applicable
382
oqclkztrbj(qewwsyesjc) = sqlznmxcak dtwmnpwggu (gjjyuugonf )
-
05 Sep 2021
Not Applicable
649
sqljplafwb(hocvcvbcys): HR = 0.48 (95% CI, 0.35 - 0.66)
-
30 Aug 2021
Placebo
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