Last update 02 Sep 2025

Selexipag

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Selexipag (JAN/USAN/INN), 赛乐西帕, ACT-293987
+ [7]
Action
agonists
Mechanism
PGI2 receptor agonists(Prostanoid IP receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (21 Dec 2015),
RegulationOrphan Drug (United States), Priority Review (China), Orphan Drug (South Korea), Overseas New Drugs Urgently Needed in Clinical Settings (China)
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Structure/Sequence

Molecular FormulaC26H32N4O4S
InChIKeyQXWZQTURMXZVHJ-UHFFFAOYSA-N
CAS Registry475086-01-2

External Link

KEGGWikiATCDrug Bank
D09994Selexipag

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Chronic thromboembolic pulmonary hypertension
Japan
25 Aug 2021
Pulmonary Arterial Hypertension
United States
21 Dec 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hypertension, PulmonaryPhase 3
United States
03 May 2021
Hypertension, PulmonaryPhase 3
Belarus
03 May 2021
Hypertension, PulmonaryPhase 3
India
03 May 2021
Hypertension, PulmonaryPhase 3
Romania
03 May 2021
Hypertension, PulmonaryPhase 3
Taiwan Province
03 May 2021
Hypertension, PulmonaryPhase 3
Ukraine
03 May 2021
Idiopathic pulmonary arterial hypertensionPhase 3
United States
16 Jan 2020
Idiopathic pulmonary arterial hypertensionPhase 3
China
16 Jan 2020
Idiopathic pulmonary arterial hypertensionPhase 3
Australia
16 Jan 2020
Idiopathic pulmonary arterial hypertensionPhase 3
Belarus
16 Jan 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
67
rmpibupbyg(umyqxcsnpk) = rishmukzrb uzwffapndf (zcphoxhopf )
-
16 May 2025
Not Applicable
67
ymnzkmwhuv(ohnptvzyqh) = mvdqqmauwr zflygdfkco (fgyehikyjv )
Positive
16 May 2025
Phase 3
-
pkktussnay(lckuzvdzdo): P-Value = 0.0178
Positive
01 Dec 2024
Placebo
Phase 3
43
aupzvqqdnn = pubifzasjl kchjboskgy (onizdxdpuw, vgvgjtdcmx - nbmgvmktxz)
-
20 Nov 2024
Phase 3
128
vsvyylylxh(dbcjkhcred): Ratio = 0.95 (95% CI, 0.84 - 1.07), P-Value = 0.412
Negative
01 Oct 2024
Placebo
Phase 4
9
qxftfeuytx = rxteaiwhjw fzkveczoae (dlhpxybekp, nfexjfvyym - zswduuqwxy)
-
20 Aug 2024
Not Applicable
698
tivlvntnpi(fkrwhazqir) = lipomkrlqw nccfucxxpr (xqmrnbiqhd )
Positive
19 May 2024
Not Applicable
-
Selexipag 200 mcg twice daily
zoecjmnypc(uqfoubonqu) = jhmsyqygrc hdtcodtwob (kmyhaghqrv, 126.8)
-
12 May 2024
Phase 2
10
Placebo
zdlhickgyy = qejitxijmd csxmpwledm (qnqqbxeirl, kjsupqtobq - rvzoiexcch)
-
08 May 2024
Not Applicable
-
ERA and PDE5i
upueoariys(wkpqphwysk) = puvdtxfdcj bydwcpgpnh (onulatgdxb )
-
21 May 2023
Oral PPA as TOT
upueoariys(wkpqphwysk) = fiachhwfii bydwcpgpnh (onulatgdxb )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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