Last update 13 Sep 2025

CLG-561

Overview

Basic Info

Drug Type
Biological products
Synonyms
NOV-7
Target
properdin
Action
inhibitors
Mechanism
properdin inhibitors(complement factor properdin inhibitors)
Therapeutic Areas
Congenital DisordersEye Diseases
Active Indication-
Inactive Indication
Age Related Macular DegenerationGeographic Atrophy
Originator Organization
MorphoSys AGMorphoSys AG
Active Organization-
Inactive Organization
Alcon Research Ltd.Novartis Institutes for BioMedical Research GmbH & Co. KG
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with CLG-561
NCT02515942
/ CompletedPhase 2
A Randomized, Multi-Center, Single Masked, Sham Controlled, Proof-of-Concept Study of Intravitreal CLG561 as a Monotherapy and in Combination With LFG316 in Subjects With Geographic Atrophy
NCT01835015
/ CompletedPhase 1
A Multi-Center, Open-Label, Single Ascending Dose Study To Assess the Safety, Tolerability, and Serum Pharmacokinetics of Intravitreal CLG561 in Subjects With Advanced Age-Related Macular Degeneration
100 Clinical Results associated with CLG-561
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100 Translational Medicine associated with CLG-561
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100 Patents (Medical) associated with CLG-561
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100 Deals associated with CLG-561
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Geographic AtrophyPhase 2-
Alcon Research Ltd.
25 Sep 2015
Geographic AtrophyPhase 2-
Novartis Institutes for BioMedical Research GmbH & Co. KG
25 Sep 2015
Age Related Macular DegenerationPhase 1-
Alcon Research Ltd.
01 May 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT02515942 (CTgov)
Phase 2
Geographic Atrophy
114
(CLG561)
pxtpoqufgv = aaqhnaderh eexequuenb (fgpciqfblu, zqdomeypmz - cwtktmslmo)
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-
19 Dec 2018
(CLG561+LFG316)
pxtpoqufgv = ipselymtvb eexequuenb (fgpciqfblu, kxlhzdgcim - wtfjogjjke)
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ARVO2016
Phase 2
Age Related Macular Degeneration
-
kvahetuvoh(dqjblhhcjj) = fpxebzvubl gxziqwmibk (npueikgfok )
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-
01 May 2016
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Approval

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Regulation

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