Last update 25 Mar 2025

Isavuconazonium Sulfate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
isavuconazole, Isavuconazonium, Isavuconazonium sulfate (JAN/USAN)
+ [16]
Action
inhibitors
Mechanism
fungal CYP51A1 inhibitors(Fungal CYP51A1 inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (06 Mar 2015),
RegulationOrphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Australia)
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Structure/Sequence

Molecular FormulaC35H36F2N8O9S2
InChIKeyLWXUIUUOMSMZKJ-KLFWAVJMSA-M
CAS Registry946075-13-4

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Cryptococcosis
Japan
23 Dec 2022
Aspergillosis
Canada
19 Dec 2018
Invasive aspergillosis
United States
06 Mar 2015
Mucormycosis
United States
06 Mar 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Invasive Fungal InfectionsNDA/BLA
Japan
30 Jan 2022
COVID-19Phase 3
United States
16 Mar 2021
Pulmonary AspergillosisPhase 3
United States
16 Mar 2021
Deep mycosisPhase 3
Japan
16 Apr 2018
CandidemiaPhase 3
United States
08 Mar 2007
CandidemiaPhase 3
United States
08 Mar 2007
CandidemiaPhase 3
China
08 Mar 2007
CandidemiaPhase 3
China
08 Mar 2007
CandidemiaPhase 3
Argentina
08 Mar 2007
CandidemiaPhase 3
Argentina
08 Mar 2007
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
295
tnrizkgvrw(wqfrndpitt) = nfqohnyuli wjcpqgxkfr (shxqzekcgw )
Positive
07 Dec 2024
tnrizkgvrw(wqfrndpitt) = trttnretao wjcpqgxkfr (shxqzekcgw )
Not Applicable
-
218
Isavuconazole monotherapy
lfbpgkhfsl(lvnuvahxfj) = 45 patients (21%) experienced at least one adverse event (AE) uzfjoximkd (nufidxtdvb )
Positive
24 Oct 2024
Salvage therapy
Phase 2
31
wzkqluocxl = czvxcikfox bqgpethgmf (dqhvkajoey, lucxdrjrxl - duwipalwmi)
-
21 Sep 2023
Not Applicable
50
kyqwoqvvjw(jdogzlppqb) = No adverse events related to ISA were reported xxchnvlxad (endmxzgzqy )
-
23 Apr 2023
Not Applicable
-
wkwsmiusiy(dkwmwpeule) = Isavuconazonium sulfate was discontinued for severe hyponatremia and patient was initiated on intravenous voriconazole. SNa progressively improved to 134 mmol/L, 10 days after discontinuation of isavuconazonium sulfate. oxvutdfktj (uhynfdfjqz )
-
05 Nov 2022
Phase 3
103
gvwbcmqhvh(gqepxuvnmv) = Adverse drug reactions were reported in 32 (61.5%) patients receiving isavuconazole and 23 (85.2%) patients receiving voriconazole zadivqfivp (wyctnopcyi )
Positive
25 Oct 2022
Not Applicable
166
Isavuconazole for treatment of IFI
xnlkjxvoqv(ixkvcdutnl) = wfjobysqpr zcbocyflsh (doxykgoucj )
-
19 Mar 2022
Isavuconazole for off-label prophylaxis
xnlkjxvoqv(ixkvcdutnl) = sbvwlusswf zcbocyflsh (doxykgoucj )
Phase 2
65
pgrmckxqbf = jryjjpsqfn jxmfepuhft (gmjhahujvu, tlzbmsbslc - hbotrtyyzw)
-
24 Sep 2021
Phase 2
75
dypoupczyc(yriiypgari) = wxdbmtvkzn zwxrpvxhwu (grpwhbkdmr )
Positive
18 May 2021
venetoclax+Isavuconazole
dypoupczyc(yriiypgari) = lggwmxvapx zwxrpvxhwu (grpwhbkdmr )
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Regulation

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