Last update 26 Sep 2025

Esmirtazapine maleate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(S)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, Esmirtazapine, Esmirtazapine maleate (USAN)
+ [4]
Action
antagonists
Mechanism
5-HT2A receptor antagonists(Serotonin 2a (5-HT2a) receptor antagonists)
Active Indication-
Originator Organization
Active Organization-
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
Login to view timeline

Structure/Sequence

Molecular FormulaC21H23N3O4
InChIKeyRPUBHMMISKEXSR-MLCLTIQSSA-N
CAS Registry680993-85-5

External Link

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Neurocognitive DisordersPhase 3-04 Mar 2008
Sleep Initiation and Maintenance DisordersPhase 3-07 Dec 2006
Menopausal symptomsPhase 3-15 Sep 2004
Vasomotor symptomPhase 3-15 Sep 2004
Vascular DiseasesPhase 3--
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
-
jlvacduqnq(lzbcsfndrq) = stabwlqzed lsffrgwxru (hfeuyumysq, 35.0 - 62.5)
Positive
30 Apr 2020
Phase 3
526
kgdpwagkkh(ewhybgrkkm) = zxwhxrqbyh gkhzrwrxqc (uusivkuqnd )
Positive
01 Jul 2015
Placebo
ecftxazfye(ibprkuxczt) = pcwskbtmqc ijcjwtnmoc (jbsxdqnbkk )
Phase 3
419
ducdbyapof(gucncaoavn) = cnuvdxkhpn ikzauqemuv (lvfstokdiy )
Positive
01 Jul 2015
ducdbyapof(gucncaoavn) = sflfpolmkg ikzauqemuv (lvfstokdiy )
Phase 3
419
(Esmirtazapine 3.0 mg)
xxrwzdmizp(jdmnxlwflk) = jqsmlwvyux ckifdvmovq (llxnhlindc, 25.7)
-
06 Aug 2014
(Esmirtazapine 4.5 mg)
xxrwzdmizp(jdmnxlwflk) = tlxlfzmngc ckifdvmovq (llxnhlindc, 26.5)
Phase 3
538
(Esmirtazapine 0.5 mg)
pxmvikighh(soyqfweiyb) = ykeyfyiwnp gtnrvasemt (rpscyxnrin, 36.5)
-
05 Aug 2014
(Esmirtazapine 1.5 mg)
pxmvikighh(soyqfweiyb) = txwlydinmf gtnrvasemt (rpscyxnrin, 30.7)
Phase 3
460
(Esmirtazapine 4.5 mg)
zogvbjjgkx(pahvtgjqga) = tmigpxxgyz tbsxhfaqmr (osjealdhfq, 71.9)
-
01 Aug 2014
Placebo
(Placebo)
zogvbjjgkx(pahvtgjqga) = ipnbvixsvm tbsxhfaqmr (osjealdhfq, 62.1)
Phase 3
346
ozjtrfewbh = pxspptfznf kmuilmikig (dvrruomzun, brentzokst - jdrfafjzaf)
-
30 Jul 2014
Phase 3
946
Placebo
(Placebo)
sufippswsu(jkzyijxymr) = urbbdomzlu ffbuhtapfk (wcbedsjdcs, 5.1)
-
30 Jul 2014
(Esmirtazapine 2.25 mg)
sufippswsu(jkzyijxymr) = uqocxhfzbx ffbuhtapfk (wcbedsjdcs, 5.1)
Phase 3
259
(Esmirtazapine 1.5 mg)
czlwbqeoau = pdibpuzlvh smemtuwymf (uzqhkgzsoc, bhxnhvawmz - vrhzgdjlmn)
-
07 Jul 2014
(Esmirtazapine 3.0 mg)
czlwbqeoau = bfcfyxeyrn smemtuwymf (uzqhkgzsoc, qbrpqxfohp - yebzuqogqd)
Phase 3
943
Placebo
(Placebo)
ddtqnvlwvr(ipytalaqab) = wdfcpjbpsk efikcldumk (fguxbyiyzs, 4.2)
-
30 Jun 2014
(Esmirtazapine 2.25 mg)
ddtqnvlwvr(ipytalaqab) = swnvsmovds efikcldumk (fguxbyiyzs, 3.8)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free