Last update 12 Dec 2024

VTP-195183

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AGN 195183, AGN-195183, IRX 5183
+ [4]
Target
Mechanism
RARα agonists(Retinoic acid receptor alpha agonists)
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC22H22ClF2NO4
InChIKeyPNAWUIKCVQSLFG-UHFFFAOYSA-N
CAS Registry367273-07-2

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Promyelocytic LeukemiaPhase 2
US
01 Apr 2008
NeutropeniaPhase 2
AU
15 Oct 2005
Breast CancerPhase 2
US
13 Nov 2002
Stem cell mobilisationPhase 2
AU
--
Chronic Myelomonocytic LeukemiaPhase 1
US
30 Jan 2017
Chronic Myelomonocytic LeukemiaPhase 1
US
30 Jan 2017
Myelodysplastic SyndromesPhase 1
US
30 Jan 2017
Myelodysplastic SyndromesPhase 1
US
30 Jan 2017
Refractory acute myeloid leukemiaPhase 1
US
30 Jan 2017
Refractory acute myeloid leukemiaPhase 1
US
30 Jan 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
11
ipdsorunlc(qvcfdvzari) = cAE included hypertriglyceridemia, fatigue, dyspnea, and edema. 3 pts at the first dose level developed asymptomatic Grade 3 hypertriglyceridemia kbemmidqyc (ffboiarlmo )
Positive
23 Oct 2020
Phase 1
15
ezqgurlgxp(plwwfhuxko) = 2 of 4 pts treated had gr 3 elevation of alkaline phosphatase ofivzugntn (vypiswhrkn )
Positive
15 Jul 2004
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Regulation

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