Delving into the Latest Updates on Sodium nitrite with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

sodium nitrite (sustained release, peripheral artery disease), AIR001, JAN-101

+ [2]

Target-

Action

donors

Mechanism

Nitric oxide donors

Therapeutic Areas

Other DiseasesCardiovascular Diseases

Active Indication

PoisoningHypertension

Inactive Indication

Acute myocardial infarctionAnemia, Sickle CellCOVID-19+ [16]

Originator Organization

Hope Pharmaceuticals, Inc.

Active Organization

The University of Alabama at Birmingham

Hope Pharmaceuticals, Inc.

Inactive Organization

Aires Pharmaceuticals, Inc.

ALT5 Sigma Corp.

TheraVasc, Inc.

+ [1]

License Organization

TheraVasc, Inc.Soin Therapeutics LLC

ALT5 Sigma Corp.

+ [1]

Drug Highest PhaseApproved

First Approval Date

United States (14 Feb 2012),

Poisoning

Regulation-

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Structure/Sequence

Molecular FormulaHNNaO2

InChIKeyZAOCWQZQPKGTRN-UHFFFAOYSA-N

CAS Registry7632-00-0

The purpose of the study is to increase the in vivo levels of nitric oxide by generating nitric oxide donor compound S-nitrosoacetylcysteine (SNOAC) using the mixture of sodium nitrite and N-acetylcysteine crystals in the sublingual space. The generated SNOAC rapidly diffuses into blood circulation thereby decrease the systemic blood pressure. This compound can be an alternative to organic nitrate NO donor drugs without developing tolerance in patients.

Start Date27 Mar 2024

Sponsor / Collaborator

The University of Alabama at Birmingham

ACTRN12622001330730

/ RecruitingPhase 1/2IIT

Elucidating the effects of nebulized sodium nitrite and argon on blood pressure and cerebrovascular haemodynamics in healthy adults and hypertensive patients

Start Date09 Jan 2023

Sponsor / Collaborator

Auckland University

100 Clinical Results associated with Sodium nitrite

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100 Translational Medicine associated with Sodium nitrite

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100 Patents (Medical) associated with Sodium nitrite

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10,833

Literatures (Medical) associated with Sodium nitrite

01 Dec 2025·New Biotechnology

Effect of culture medium composition and reuse on the growth of Porphyridium cruentum

Article

Author: Rivera-Sánchez, Elia ; Salinas-García, María ; Lafarga, Tomás ; Villaró-Cos, Silvia ; Cáceres-Ferroni, Florencia

The aim of this study was to develop a fertiliser-based culture medium to reduce production costs and to enhance the sustainability of producing Porphyridium cruentum, a red marine microalga of commercial interest. Additionally, the impact of water recirculation on microalgal growth was assessed. Overall, the results indicated that the nitrogen source significantly affected biomass growth, with sodium nitrate supporting higher biomass productivity (0.23 g·L^-1·day^-1), surpassing sodium nitrite (0.18 g·L^-1·day^-1) and ammonium chloride (0.14 g·L^-1·day^-1). Urea had a negative impact on growth. A N:P molar ratio of 20:1 increased biomass productivity by approximately 24 % compared to the lower ratio studied (8:1) while also reducing phosphorus demand. The optimal medium composition was: 1.75 g·L^-1 NaNO₃, 0.23 g·L^-1 K₂HPO₄·3 H₂O, 0.04 g·L^-1 CaCl₂, 0.49 g·L^-1 MgSO₄·7 H₂O, and 24.0 mg·L^-1 Karentol®. Lastly, water reutilisation negatively impacted biomass concentration, promoting the accumulation of extracellular organic carbon and bacteria as well as increasing the viscosity and turbidity of the culture.

01 Nov 2025·JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY

Fe-single-atom/Fe3C-decorated carbon nanotube electrocatalyst derived from modified Fe-ZIF-8

Author: Hur, Seung Hyun ; Nguyen, Duc-Viet ; Jana, Jayasmita ; Choi, Won Mook ; Chung, Jin Suk

In this study, Fe-single-atom-decorated carbon-nanotube-based electrocatalysts with small concentrations of Fe₃C nanoparticles (AOFA-20) were obtained by calculating Fe-ZIF-8 functionalized by 3-amino-1,2,4-triazole in a crucible cup without a cap.The as-synthesized AOFA-20 demonstrated outstanding ORR activity (E_1/2 = 0.828 V vs. RHE), surpassing 20 % Pt/C (0.808 V) in 0.1 M KOH.It also exhibited superior long-term stability and methanol tolerance over com. RuO₂ and Pt/C.In practical zinc-air batteries, AOFA-20 achieved a narrow voltage gap (1.19 V) and exceptional cycling stability (>560 h), outperforming Pt/C- RuO₂ (1.41 V, 65 h).These findings highlight useful information for the development of AOFA-20 catalyst with abundant active sites for next-generation energy storage and conversion devices.

01 Oct 2025·JOURNAL OF EMERGENCY MEDICINE

Sodium Nitrite-Induced Methemoglobinemia in A Conflict Area: A Case Series from Sudan and Implications for Humanitarian Response

Article

Author: Maio, Elisabetta ; Abdalla, Sohayda Hussein Abdalla ; Maida, Francesca ; Merli, Daniele ; Dafalla, Yassin Mohamed Ahmed ; Abdalmahmoud, Monera ; Volpi, Caterina ; Hamed, Areej Mohammed ; Giovanella, Elena ; Salimova, Maya

BACKGROUND:

With the ongoing conflict started in 2023, Sudan is facing one of the world's worst food crises and its healthcare system has been severely disrupted. Civilians increasingly rely on unsafe food sources, raising the risk of toxic exposures such as sodium nitrite ingestion, which can lead to life-threatening methemoglobinemia.

CASE REPORT:

We describe a series of 15 individuals exposed to sodium nitrite, mistakenly used in place of table salt. One patient was dead on arrival; the others were diagnosed with methemoglobinemia and successfully treated with methylene blue or ascorbic acid. Food analysis confirmed high levels of sodium nitrite contamination. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: In conflict settings, disrupted food supply chain and collapsed healthcare services can increase the risk of toxicological emergencies. This case series underscores how early recognition and access to essential treatments such as methylene blue are critical for successful management of methemoglobinemia. Beyond clinical care, understanding the context of the conflict and collaborating with local communities is essential to ensure appropriate and effective responses in challenging settings.

39

News (Medical) associated with Sodium nitrite

02 Apr 2025

·pipelinereview.com

AIRNA Raises Oversubscribed $155 Million Series B Financing to Fund Phase 1/2 Clinical Trial for Alpha-1 Antitrypsin Deficiency and Future Pipeline

Financing led by Venrock Healthcare Capital Partners with co-lead Forbion Growth, and participation from RTW Investments, Nextech Invest, and other new investors Current investors ARCH Venture Partners, Forbion Ventures, ND Capital, and others also participated AIRNA expected to file clinical trial application for Alpha-1 antitrypsin deficiency (AATD) RNA editing product candidate (AIR-001) with potential best-in-class profile in 2H 2025 CAMBRIDGE, MA, USA & TÜBINGEN, Germany I April 01, 2025 I AIRNA, a biotech company pioneering RNA editing therapeutics to transform the lives of patients with rare and common conditions, today announced the closing of an oversubscribed $155 million Series B financing. The financing was led by Venrock Healthcare Capital Partners, co-led by Forbion Growth, and included participation from RTW Investments, Nextech Invest, ARCH Venture Partners, Forbion Ventures, ND Capital, and other new and existing investors. AIRNA will use the proceeds to advance its lead RNA editing product candidate (AIR-001) for AATD into a Phase 1/2 clinical trial, and to develop a pipeline of novel RNA-editing medicines for cardiometabolic and other diseases. “AIRNA is developing a new class of genetic medicines that could provide functional cures for a wide range of diseases,” said Kris Elverum, President and Chief Executive Officer of AIRNA. “This partnership of new and existing investors allows us to rapidly deliver AIR-001 to patients with AATD, as well as progress a pipeline of medicines to realize the full potential of RNA editing.” AATD is caused by mutations in the SERPINA1 gene that lead to insufficient levels of functional alpha-1 antitrypsin (M-AAT) protein, which results in lung and liver disease. AIR-001 precisely repairs the most common, harmful SERPINA1 mutation (PiZ) to address the underlying cause of both lung and liver disease and restore functional M-AAT production. AIR-001 was designed for potent and durable M-AAT production, convenient, subcutaneous dosing, and well-tolerated safety to give patients a preferred therapeutic option. “Patients with AATD have limited therapeutic options, and AIRNA is developing a potentially best-in-class medicine that has been optimized for potency, durability, and safety,” said Ken Greenberg, M.D., partner at Venrock Healthcare Capital Partners. “Venrock is thrilled to collaborate with the tremendous team at AIRNA, and a world-class investor syndicate, to bring novel RNA editing medicines to patients.” AIRNA’s proprietary platform harnesses natural mechanisms to potently edit a target RNA with a safe and flexible medicine. Precise RNA editing has unique potential to safely introduce beneficial genetic variants that promote optimal health, in addition to repairing disease-driving mutations, such as those causing AATD. AIRNA identifies variants that drive health through human genetics, and is developing new medicines to transform the lives of patients with cardiometabolic and other diseases. “AIRNA’s innovative approach to RNA editing has the distinctive potential to improve health across large populations by introducing healthy genetic variants for many conditions. We are excited to support the expansion of AIRNA’s pipeline of life-changing medicines and the advancement AIR-001 into the clinic,” said Dirk Kersten, Managing Partner at Forbion. Alongside this financing, AIRNA announced the appointment of Melissa McCracken, Ph.D., a partner at Nextech Invest, to the Board of Directors. Dr. McCracken has a track record of growing the next generation of innovative biopharma companies, with a focus on precision approaches. About AIRNA AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health across both rare and broad populations. RNA editing offers the precision of genetic medicine approaches while maintaining treatment convenience, flexibility, and reversibility. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health. AIRNA’s lead program has the potential to be a best-in-class therapeutic for alpha-1 antitrypsin deficiency (AATD). AIRNA has headquarters in Cambridge, MA, with research operations in Tübingen, Germany. Learn more at https://airna.com/ . SOURCE: AIRNA

Executive ChangesiRNA

02 Apr 2025

·www.pharmaceutical-technology.com

AIRNA secures $155m to bring RNA-candidate to clinic

AIRNA’s total capital raised so far is $245m. Credit: sesame via Getty Images. AIRNA has raised $155m in Series B financing to advance its RNA editing pipeline, and kick-start a clinical trial for its lead candidate, AIR-001. Venrock Healthcare Capital Partners and Forbion Growth co-led the new round, bringing AIRNA’s total raised capital to $245m. The US and Germany-based biotech plans to file a clinical trial application (CTA) for its lead candidate, AIR-001, for alpha-1 antitrypsin deficiency (AATD) by H2 2025. The company is developing AIR-001 as an investigational RNA editor – a therapy designed to modify RNA sequences to correct disease-causing mutations. This approach is different to DNA editing approaches such as clustered regularly interspaced short palindromic repeats (CRISPR), which make permanent changes to the genome. RNA editing is a reversible process that allows for targeted corrections without altering the underlying genetic code. The Series B funds will support the launch of a Phase I/II clinical trial for AIR-001 and the further development of other RNA-editing candidates, primarily targeting cardiometabolic diseases. AATD is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes the AAT protein. Under normal circumstances, AAT is produced in the liver and transported to the lungs, where it regulates enzyme activity to prevent tissue damage. In patients with AATD, mutations can prevent AAT from exiting the liver, leading to toxic protein accumulation that damages the liver while also depriving the lungs of necessary protection. This can result in progressive lung disease, liver dysfunction, and symptoms such as shortness of breath, fatigue, and jaundice. The AATD treatment landscape is becoming increasingly competitive as multiple biotechs advance RNA-editing candidates. Korro Bio is investigating its candidate KRRO-110 in the Phase I/IIa REWRITE clinical trial (NCT06677307), with interim data expected in H2 2025. The company announced last month that the dosing of the first two cohorts had been completed, and the trial is expected to conclude next year. Wave Life Sciences is developing WVE-006, which demonstrated targeted RNA editing in the first two patients treated in the Phase Ib/IIa RestorAATion-2 clinical trial (NCT06405633). The growing interest in RNA editing has also drawn investment from major pharmaceutical companies. In November 2023, Roche expanded its partnership to develop a one-time RNA editing therapy using ShapeTX’s AI-powered platform for an undisclosed disease. In September 2024, Novo Nordisk and Korro Bio announced a collaboration leveraging Korro’s OPERA platform to enable oligonucleotide-directed RNA edits for two undisclosed targets, initially focused on cardiometabolic diseases. The deal included up to $530m in upfront, development, and commercial milestone payments, along with tiered royalties and R&D funding. Not all genetic medicine approaches for AATD have progressed as planned. In January 2025, Intellia Therapeutics discontinued the development of its CRISPR-based gene therapy NTLA-3001, which was intended to correct the SERPINA1 mutation at the DNA level. Preparations for the Phase I/II trial were halted, along with other early-stage programmes, signalling a shift in the company’s pipeline priorities. With fresh funding and a CTA planned for later this year, AIRNA is positioning itself within the growing RNA editing field. Forbion managing partner Dirk Kersten said: “AIRNA’s innovative approach to RNA editing has the distinctive potential to improve health across large populations by introducing healthy genetic variants for many conditions. We are excited to support the expansion of AIRNA’s pipeline of life-changing medicines and the advancement of AIR-001 into the clinic.”

Clinical StudyOligonucleotidesiRNAGene Therapy

01 Apr 2025

·www.businesswire.com

AIRNA Raises Oversubscribed $155 Million Series B Financing to Fund Phase 1/2 Clinical Trial for Alpha-1 Antitrypsin Deficiency and Future Pipeline

CAMBRIDGE, Mass. & TÜBINGEN, Germany--(BUSINESS WIRE)--AIRNA, a biotech company pioneering RNA editing therapeutics to transform the lives of patients with rare and common conditions, today announced the closing of an oversubscribed $155 million Series B financing. The financing was led by Venrock Healthcare Capital Partners, co-led by Forbion Growth, and included participation from RTW Investments, Nextech Invest, ARCH Venture Partners, Forbion Ventures, ND Capital, and other new and existing investors. AIRNA will use the proceeds to advance its lead RNA editing product candidate (AIR-001) for AATD into a Phase 1/2 clinical trial, and to develop a pipeline of novel RNA-editing medicines for cardiometabolic and other diseases. “AIRNA is developing a new class of genetic medicines that could provide functional cures for a wide range of diseases,” said Kris Elverum, President and Chief Executive Officer of AIRNA. “This partnership of new and existing investors allows us to rapidly deliver AIR-001 to patients with AATD, as well as progress a pipeline of medicines to realize the full potential of RNA editing.” AATD is caused by mutations in the SERPINA1 gene that lead to insufficient levels of functional alpha-1 antitrypsin (M-AAT) protein, which results in lung and liver disease. AIR-001 precisely repairs the most common, harmful SERPINA1 mutation (PiZ) to address the underlying cause of both lung and liver disease and restore functional M-AAT production. AIR-001 was designed for potent and durable M-AAT production, convenient, subcutaneous dosing, and well-tolerated safety to give patients a preferred therapeutic option. “Patients with AATD have limited therapeutic options, and AIRNA is developing a potentially best-in-class medicine that has been optimized for potency, durability, and safety,” said Ken Greenberg, M.D., partner at Venrock Healthcare Capital Partners. “Venrock is thrilled to collaborate with the tremendous team at AIRNA, and a world-class investor syndicate, to bring novel RNA editing medicines to patients.” AIRNA’s proprietary platform harnesses natural mechanisms to potently edit a target RNA with a safe and flexible medicine. Precise RNA editing has unique potential to safely introduce beneficial genetic variants that promote optimal health, in addition to repairing disease-driving mutations, such as those causing AATD. AIRNA identifies variants that drive health through human genetics, and is developing new medicines to transform the lives of patients with cardiometabolic and other diseases. “AIRNA’s innovative approach to RNA editing has the distinctive potential to improve health across large populations by introducing healthy genetic variants for many conditions. We are excited to support the expansion of AIRNA’s pipeline of life-changing medicines and the advancement AIR-001 into the clinic,” said Dirk Kersten, Managing Partner at Forbion. Alongside this financing, AIRNA announced the appointment of Melissa McCracken, Ph.D., a partner at Nextech Invest, to the Board of Directors. Dr. McCracken has a track record of growing the next generation of innovative biopharma companies, with a focus on precision approaches. About AIRNA AIRNA is harnessing advances in genetics to develop transformative RNA-editing medicines that improve human health across both rare and broad populations. RNA editing offers the precision of genetic medicine approaches while maintaining treatment convenience, flexibility, and reversibility. Our proprietary platform is based on groundbreaking research by pioneers of the field and company co-founders Thorsten Stafforst (University of Tübingen) and Jin Billy Li (Stanford University) and enables optimal potency, safety, and delivery. AIRNA is advancing a robust pipeline of therapeutic candidates that are designed to provide functional cures for severe or chronic diseases by repairing harmful genetic variants or introducing beneficial variants promote optimal health. AIRNA’s lead program has the potential to be a best-in-class therapeutic for alpha-1 antitrypsin deficiency (AATD). AIRNA has headquarters in Cambridge, MA, with research operations in Tübingen, Germany. Learn more at https://airna.com/.

Executive ChangesiRNA

100 Deals associated with Sodium nitrite

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R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Poisoning	United States	Hope Pharmaceuticals, Inc.	14 Feb 2012

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Peripheral Vascular Diseases	Phase 2	United States	ALT5 Sigma Corp.	23 Jul 2020
COVID-19	Phase 2	United States	Hope Pharmaceuticals, Inc.	22 Jul 2020
Lung Injury	Phase 2	United States	Hope Pharmaceuticals, Inc.	22 Jul 2020
Respiratory Distress Syndrome, Acute	Phase 2	United States	Hope Pharmaceuticals, Inc.	22 Jul 2020
Respiratory Failure	Phase 2	United States	Hope Pharmaceuticals, Inc.	22 Jul 2020
Heart failure with normal ejection fraction	Phase 2	United States	Aires Pharmaceuticals, Inc.	10 Aug 2016
Cystic Fibrosis	Phase 2	United States	Mast Therapeutics, Inc.	01 Feb 2016
Pseudomonas Infections	Phase 2	United States	Mast Therapeutics, Inc.	01 Feb 2016
Diabetic peripheral neuropathic pain	Phase 2	United States	TheraVasc, Inc.	28 Apr 2015
Familial Primary Pulmonary Hypertension	Phase 2	United States	Aires Pharmaceuticals, Inc.	01 Nov 2012

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT02694393 (CTgov)	Phase 1/2	Pseudomonas Infections \| Cystic Fibrosis	4	sodium nitrite	flqoblkhbw(afsqbeteuw) = dgomolbbdy tcnycqzwxs (fswixgdolk, hyuuomxcyz - jhtftzorro) View more	-	24 Jun 2024
NCT03015402 (PH-HFpEF, CTgov)	Phase 2	Secondary hypertension \| Heart failure with normal ejection fraction \| Hypertension, Pulmonary	33	Placebo Oral Capsule	zddmcmhmyx(ennlkvcgxl) = hcqhubzyof aguitrxsbs (yelkbwotsd, 11.34) View more	-	07 Jun 2024
NCT02713126 (INABLE, Pubmed \| Mayo Clin Proc) Manual	Phase 2	Heart failure with normal ejection fraction	92	Inorganic Nitrite 40 mg	xnfswpbqeo(qxhnfqggiv) = fjlhusbexs jmccgselwf (ubcyampzyo, 0.3 - 1.2) View more	Negative	01 Feb 2024
NCT02713126 (INABLE \| INABLE-Training Trial \| RELAX, NCT00763867; Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction, NCT02053493; Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF, NCT02742129; Inorganic Nitrite to Enhance Benefits From Exercise Training in Heart Failure With Preserved Ejection Fraction [HFpEF], NCT02713126 \| NCT02713126, CTgov)	Phase 2	Heart failure with normal ejection fraction	92	Cardiac Exercise Training (Placebo)	uvehupxofp(myeitejkeq) = ejaukwvmxn fyehrlelaa (cyvkpcadoq, 2.10) View more	-	26 Apr 2023
				Cardiac Exercise Training+Sodium Nitrite (Sodium Nitrite)	uvehupxofp(myeitejkeq) = stagvnkycr fyehrlelaa (cyvkpcadoq, 1.51) View more
NCT02433977 (NICLA, CTgov)	Phase 2	Asthma	6	Sodium Nitrate+Sodium Nitrite	nnvxiggpov(plyibyaomu) = hlagwexlne ocwexcnjqb (rbkvhslwht, 10.4) View more	-	26 Mar 2021
NCT02262078 \| NCT01932606 (Pubmed \| Eur J Heart Fail)	Phase 2	Heart failure with normal ejection fraction	51	Inhaled sodium nitrite	jmzcigqkdr(mmdgtuakko) = ajzpkaghez butwkbobpv (fanrdkornu ) View more	-	09 Jan 2021
				Intravenous sodium nitrite	jmzcigqkdr(mmdgtuakko) = iinefxhsgx butwkbobpv (fanrdkornu ) View more
NCT02412852 (CTgov)	Phase 2	Diabetic peripheral neuropathic pain	26	Sodium nitrite (40 mg TV1001sr)	jyghwdlygm = xgbovzlxis agvpdtsgvu (pvoiuqwxpy, swogoppdac - jmzgdmvwkh) View more	-	24 Apr 2020
				Sodium nitrite (80 mg TV1001sr)	jyghwdlygm = mebeykpudd agvpdtsgvu (pvoiuqwxpy, hjwtonbywi - etfylhfcar) View more
NCT02918552 (ONOH, CTgov)	Phase 2	Heart failure with normal ejection fraction	15	sodium nitrite (Sodium Nitrite)	jpocgprokt(emspokhscd) = btkddygmuz llverucfbz (datztzaiyq, 1.5) View more	-	22 Jan 2020
				placebo (Placebo)	jpocgprokt(emspokhscd) = shkljoyxiy llverucfbz (datztzaiyq, 0.5) View more
NCT01681810 (ONTX, CTgov)	Phase 2	Metabolic Syndrome \| Hypertension	20	14Nitrogen Sodium Nitrite	krwzqzgfup(nmjiwlkhqg) = waldvxbyrw cexzghkyug (dqorxunvrc, 0.58) View more	-	16 Apr 2019
NCT02742129 (INDIE-HFpEF, CTgov)	Phase 2	Heart failure with normal ejection fraction	105	Placebo (AIR001 Crossover to Placebo)	txtyqfnjsm(jcdrcfnwsw) = zpacxegmlj tuijmcfjpe (lazmmhwozm, 3.2) View more	-	13 Mar 2019
				Placebo (Placebo Crossover to AIR001)	txtyqfnjsm(jcdrcfnwsw) = qrsdfhjnzk tuijmcfjpe (lazmmhwozm, 3.8) View more