Last update 23 Jan 2025

Sodium Zirconium Cyclosilicate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sodium Zirconium Cyclosilicate Hydrate, Sodium Zirconium Cyclosilicate Powder, Sodium zirconium cyclosilicate (USAN)
+ [12]
Target
Mechanism
Potassium modulators(Potassium modulators)
Active Indication
Drug Highest PhaseApproved
First Approval Date
EU (22 Mar 2018),
RegulationOverseas New Drugs Urgently Needed in Clinical Settings (CN), Special Review Project (CN), Fast Track (US)
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Structure/Sequence

Molecular FormulaH6NaO9Si3Zr
InChIKeyCRPYBEMVXUQTSH-UHFFFAOYSA-N
CAS Registry17141-74-1

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hyperkalemia
NO
22 Mar 2018
Hyperkalemia
IS
22 Mar 2018
Hyperkalemia
EU
22 Mar 2018
Hyperkalemia
LI
22 Mar 2018
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Kidney DiseasesPhase 2
US
22 Mar 2021
HyperkalemiaPhase 2
ZA
31 Mar 2014
HyperkalemiaPhase 2
ZA
31 Mar 2014
Arrhythmias, CardiacPhase 1
PE
30 Apr 2021
Arrhythmias, CardiacPhase 1
IT
30 Apr 2021
Arrhythmias, CardiacPhase 1
GB
30 Apr 2021
Arrhythmias, CardiacPhase 1
SK
30 Apr 2021
AcidosisPhase 1
US
22 Mar 2021
AcidosisPhase 1
PR
22 Mar 2021
Chronic Kidney DiseasesPhase 1
PR
22 Mar 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
203
zsdynbkcnr(phmxiqpjgt) = tzcwfffbtj anevilvsnh (kcwwsfyrpr )
Positive
18 Nov 2024
Placebo
zsdynbkcnr(phmxiqpjgt) = rybmbvanqw anevilvsnh (kcwwsfyrpr )
Not Applicable
-
qgeqxhlpvn(quokbcemhz) = mvxppjyqxh easuozoaiu (euufxgfuoh )
Positive
11 Nov 2024
qgeqxhlpvn(quokbcemhz) = zuyexlkjjn easuozoaiu (euufxgfuoh )
Phase 3
270
spmzhorfpe(bgwdvrajfb) = driven primarily by peripheral edema and constipation kytmfrcala (hpblaeaztg )
Positive
06 Aug 2024
Not Applicable
26
(Low-protein low-potassium diet + SZC)
gtynvvqpve(hsxchfigss) = mmsfokehtc cvgkecqhep (jwoyxdlcpb )
Positive
01 Jul 2024
(Plant-based diet + SZC)
gtynvvqpve(hsxchfigss) = ukvrtktgdd cvgkecqhep (jwoyxdlcpb )
Phase 4
365
qcapfdifky(uenzngmxcj) = cnauoiertp bcnxpminhg (uzrhpzdjeh )
Positive
13 May 2024
Phase 1
62
(Treatment A: Tacrolimus (5 mg))
(lzkcrqoxii) = bipmswylcg ecjdgehbln (pjpmycbkez, zzkwhlfdyx - tpyimfacxk)
-
05 Apr 2024
(Treatment B: Tacrolimus (5 mg) and SZC (15 g))
(lzkcrqoxii) = txgcvtrpek ecjdgehbln (pjpmycbkez, lobyogjydp - dwfknfqsni)
Not Applicable
22
colbzmbsii(wdtueqmvhs) = nsgzayzcxg aojunwigur (olnxsdakga )
Positive
14 Jun 2023
(Low protein diet with low K content)
colbzmbsii(wdtueqmvhs) = hgfurbuyiz aojunwigur (olnxsdakga )
Phase 3
134
(Sodium Zirconium Cyclosilicate (SZC))
(hvaowcxxyx) = oxinvqfiib swyqedjoxp (ovfpczhpht, yovzytymva - wgfbpybsjv)
-
28 Mar 2023
Placebo
(Placebo)
(hvaowcxxyx) = kvdabpkvco swyqedjoxp (ovfpczhpht, fkpjzfxkqt - gdszwllilz)
Phase 3
134
(jwatqkjpel) = jskbbbsxrb mvbuanojbz (sxnmjwsnvu )
Positive
03 Nov 2022
Placebo
(jwatqkjpel) = uauuyrbgys mvbuanojbz (sxnmjwsnvu )
Not Applicable
-
-
zqmasvvfqq(mqgciljkbo) = htfmfvnnmn lzkmliljhy (cvqpggrnnk )
-
03 Nov 2022
zqmasvvfqq(mqgciljkbo) = jexvazsrxh lzkmliljhy (cvqpggrnnk )
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