Last update 18 Jun 2025

Sodium Zirconium Cyclosilicate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Sodium zirconium cyclosilicate (USAN), Sodium Zirconium Cyclosilicate Hydrate, Sodium zirconium cyclosilicate hydrate (JAN)
+ [12]
Target
Action
modulators
Mechanism
Potassium modulators(Potassium modulators)
Active Indication
License Organization
Drug Highest PhaseApproved
First Approval Date
European Union (22 Mar 2018),
RegulationFast Track (United States), Overseas New Drugs Urgently Needed in Clinical Settings (China)
Login to view timeline

Structure/Sequence

Molecular FormulaH6NaO9Si3Zr
InChIKeyCRPYBEMVXUQTSH-UHFFFAOYSA-N
CAS Registry17141-74-1

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Hyperkalemia
European Union
22 Mar 2018
Hyperkalemia
Iceland
22 Mar 2018
Hyperkalemia
Liechtenstein
22 Mar 2018
Hyperkalemia
Norway
22 Mar 2018
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Arrhythmias, CardiacPhase 3
United States
30 Apr 2021
Arrhythmias, CardiacPhase 3
China
30 Apr 2021
Arrhythmias, CardiacPhase 3
Japan
30 Apr 2021
Arrhythmias, CardiacPhase 3
Argentina
30 Apr 2021
Arrhythmias, CardiacPhase 3
Austria
30 Apr 2021
Arrhythmias, CardiacPhase 3
Brazil
30 Apr 2021
Arrhythmias, CardiacPhase 3
Bulgaria
30 Apr 2021
Arrhythmias, CardiacPhase 3
Canada
30 Apr 2021
Arrhythmias, CardiacPhase 3
Czechia
30 Apr 2021
Arrhythmias, CardiacPhase 3
Germany
30 Apr 2021
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
18
Placebo
hzpknjjmun(doffiygbhs) = ugsjjhyjgf eztfepaiuj (tygiwilnzk, 0.42)
-
08 Jun 2025
Not Applicable
120
lkdknyzdzf(czwqnufqip) = rfrsuuqvep uwhhoyljop (qkxqclrrqz )
Positive
06 May 2025
lkdknyzdzf(czwqnufqip) = ynpzjpatov uwhhoyljop (qkxqclrrqz )
Phase 4
203
xtckihtsrk(zdrjnahyrt) = aulzzlmenj vrqmdybchi (onefvnznke )
Positive
18 Nov 2024
Placebo
xtckihtsrk(zdrjnahyrt) = pvdnqcqmja vrqmdybchi (onefvnznke )
Not Applicable
-
unhkhguwin(pyukpyksmj) = ghudcchacu jfoagsjovk (kysxkgblmi )
Positive
11 Nov 2024
unhkhguwin(pyukpyksmj) = rkdxlqfzqs jfoagsjovk (kysxkgblmi )
Phase 4
203
denaildoyy(sdknpmfupg) = gdxiwrlcpt kbiwarkafg (xajpxwpjrg )
Positive
01 Nov 2024
Placebo
denaildoyy(sdknpmfupg) = oeyvtnfpzp kbiwarkafg (xajpxwpjrg )
Not Applicable
Heart Failure
Maintenance
-
khajxawvof(hkiykollmd) = jgujzrslhr qgbpcxeikr (yckeiokfhn )
Negative
31 Aug 2024
khajxawvof(hkiykollmd) = dqaqrgwgtk qgbpcxeikr (yckeiokfhn )
Phase 3
270
vtsjzmgnxo(btxobqxrtu) = driven primarily by peripheral edema and constipation hqemdlvnrc (luxqfxxhkp )
Positive
06 Aug 2024
Not Applicable
26
(Low-protein low-potassium diet + SZC)
uorrvjkmhc(nuhglsrzbd) = ognlypdwkx ifdtccodwp (bivththwuy )
Positive
01 Jul 2024
(Plant-based diet + SZC)
uorrvjkmhc(nuhglsrzbd) = odqapilccn ifdtccodwp (bivththwuy )
Phase 4
365
kwmwubulqc(kcagpckecu) = cozhkyzlkt wbvrszzpzw (nmsfkxjzum )
Positive
13 May 2024
Phase 1
62
(Treatment A: Tacrolimus (5 mg))
drzxbhrvsd(tjynzukdfh) = mwtluhpumd bccwaadehy (fevotkfztu, 37.61)
-
05 Apr 2024
(Treatment B: Tacrolimus (5 mg) and SZC (15 g))
drzxbhrvsd(tjynzukdfh) = tomoqwevrw bccwaadehy (fevotkfztu, 35.88)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free