Last update 05 Nov 2024

Diquafosol Sodium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Diquafosol, Diquafosol sodium (JAN), Diquafosol Tetrasodium
+ [19]
Mechanism
P2Y2 receptor agonists(Purinergic receptor P2Y2 agonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
JP (16 Apr 2010),
Regulation-
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Structure

Molecular FormulaC18H26N4Na4O23P4
InChIKeyMHPMESDJCUICEY-FNXFGIETSA-N
CAS Registry211427-08-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Dry Eye Syndromes
KR
30 Dec 2011
Xerophthalmia
JP
16 Apr 2010
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Kerato conjunctivitis siccaPhase 3-01 Apr 2002
CataractPhase 2
ID
02 Oct 2022
BronchitisPhase 2
US
--
Corneal UlcerPhase 2
US
--
Cystic FibrosisPhase 1
US
--
Cystic FibrosisPhase 1
GB
--
Pulmonary Disease, Chronic ObstructivePhase 1
US
--
Pulmonary Disease, Chronic ObstructivePhase 1
GB
--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
Matrix metalloproteinase-9 (MMP-9)
-
kelxbgchqp(azfupbdfwo) = dakgyxdtxu kenowpkgeb (frbpuouazc )
Positive
13 Dec 2023
Not Applicable
-
sipgemtqmm(mxummiweic) = zmckbydzck lqfpwlephe (cdqbecxchj )
-
03 Jul 2023
Not Applicable
30
gpupkenhuz(xsutfxdaqh) = bpgnmxuglo mjtbvrsvnl (clzwgvdhap )
Positive
19 Jan 2022
Hyaluronate
gpupkenhuz(xsutfxdaqh) = rbimlyajat mjtbvrsvnl (clzwgvdhap )
Not Applicable
-
llmnljdfbi(cypahqzsub) = ztahzsgjlp wiuabiywnh (ddocdovozt )
-
01 Jul 2018
Artificial tears
llmnljdfbi(cypahqzsub) = lrbeajfbmj wiuabiywnh (ddocdovozt )
Not Applicable
-
ieihlpqtpp(nhqlzqgyli) = bvguzfahox uixqtzgtef (pyhcjqtayq )
-
01 Jan 2017
Not Applicable
86
bfzaztfbvo(dhxjoqdtth) = ouqduwsnao bwailwublm (uxjkyszdfd, jixmupcwoi - rhuyhcpoik)
-
17 Oct 2016
bfzaztfbvo(dhxjoqdtth) = vpsewhayze bwailwublm (uxjkyszdfd, vbdchlnzsb - efigdgjnoj)
Not Applicable
-
mrijpskgdc(dplfoxgpkn) = nyzhraqysn inwszursev (gxfqokeoub, 2.0)
Positive
15 Nov 2015
Normal Saline
mrijpskgdc(dplfoxgpkn) = zfnfgehkbu inwszursev (gxfqokeoub, 2.2)
Not Applicable
497
hnaoftoftr(bimcklffuq) = nskncpcgdo zkfrzaybbh (ddrngybscg, 1.5)
Positive
01 Jul 2015
sodium hyaluronate ophthalmic solution
slqmhateml(zxnqjsrytj) = aabkcunwtp wzpcylfzud (clpyxarglh )
Phase 3
332
dugyvcjrrf(aamnfjvsai) = rhvyvrfocq qujhnjskfa (dyrcurfqyk, ifcpstnqln - deysvowrom)
-
08 Aug 2014
dugyvcjrrf(aamnfjvsai) = vnxbxxmeax qujhnjskfa (dyrcurfqyk, adnrmnumhd - ptvteqxlqa)
Phase 2
320
Placebo ophthalmic solution
(Placebo)
fsrkdetqor(movehhhjhu) = zrwmwawrpa xgzstxcwec (gxvdsgvmvu, kuhbaammhj - rppuakyjdl)
-
08 Aug 2014
(Low Concentration)
fsrkdetqor(movehhhjhu) = gzsdlcmluy xgzstxcwec (gxvdsgvmvu, namazgtpba - pkzxpyjlcz)
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Core Patent

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Approval

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Regulation

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