Last update 11 Jul 2024

Xalnesiran

Overview

Basic Info

Drug Type
Small interfering RNA
Synonyms
DCR-HBV, DCR-HBVS, Xalnesiran Sodium
+ [3]
Target
Mechanism
HBsAg inhibitors(HBsAg inhibitors), RNA interference
Active Indication
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis BPhase 2--
Hepatitis B, ChronicPhase 1
US
05 Jul 2020
Hepatitis B, ChronicPhase 1
ES
05 Jul 2020
Hepatitis B, ChronicPhase 1
FR
05 Jul 2020
Hepatitis B, ChronicPreclinical
KR
05 Jul 2020
Hepatitis B, ChronicPreclinical
GB
05 Jul 2020
Hepatitis B, ChronicPreclinical
TW
05 Jul 2020
Hepatitis B, ChronicPreclinical
CN
05 Jul 2020
Hepatitis B, ChronicDiscovery
BG
05 Jul 2020
Hepatitis B, ChronicDiscovery
CA
05 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
82
(mprmjlgxps) = The most common adverse event was mild injection site reaction cbcaagmblq (dxeqolrjko )
-
29 Jul 2023
Phase 1
12
(Group C :1.5 mg/kg cohort (n=4),3.0 mg/kg cohort (n=4),6.0 mg/kg cohort (n=4))
(kznmgbcpua) = soixkzqbeo flmgylvxwx (sztzpbasqb )
Positive
16 Nov 2020
Placebo
(Group C)
(kznmgbcpua) = hckfndfpjq flmgylvxwx (sztzpbasqb )
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Approval

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Regulation

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