An Open-label, Multicenter, Phase 1a/1b Study of Aplitibart (IGM-8444) as a Single Agent and in Combination in Participants With Relapsed, Refractory, or Newly Diagnosed Cancers

This study is a first-in-human, Phase 1a/1b, multicenter, open-label study to determine the safety, tolerability, and pharmacokinetics of aplitabart as a single agent and in combination in participants with relapsed and/or refractory solid or hematologic cancers, as well as newly diagnosed cancers, and an open-label, randomized study of aplitabart+FOLFIRI+bevacizumab.

Start Date23 Sep 2020

Sponsor / Collaborator

IGM Biosciences, Inc.

NCT03803774

/ TerminatedPhase 1IIT

Birinapant and Intensity Modulated Re-Irradiation Therapy (IMRRT) for Locoregionally Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

This phase I trial studies the side effects and best dose of birinapant when given together with intensity modulated re-irradiation therapy (IMRRT) in treating patients with head and neck squamous cell carcinoma that has come back at or near the same place as the original (primary) tumor (locally recurrent). Birinapant may stop the growth of tumor cells by blocking inhibitor of apoptosis (IAP), a protein needed for tumor cell survival. IMRRT uses thin beams of radiation of different intensities that are aimed at the tumor from many angles. This type of re-irradiation therapy reduces the damage to healthy tissue near the tumor. Giving birinapant with IMRRT may lower the chance of head and neck squamous cell carcinoma growing or spreading.

Start Date25 Sep 2019

Sponsor / Collaborator

National Cancer Institute

NCT02756130

/ WithdrawnPhase 1/2IIT

A Phase I/II, Single Center, Proof-of-Concept Study of Birinapant in Combination With Platinum Based Chemotherapy Targeting Recurrent High Grade Serous Ovarian Carcinomas (HGSOC)

This phase I/II trial studies how well birinapant and carboplatin work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. Drugs used in chemotherapy, such as birinapant and carboplatin work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.

Start Date01 Aug 2018

Sponsor / Collaborator

Jonsson Comprehensive Cancer Center

[+2]

100 Clinical Results associated with Birinapant

100 Translational Medicine associated with Birinapant

100 Patents (Medical) associated with Birinapant

202

Literatures (Medical) associated with Birinapant

01 Mar 2025·Nature Chemical Biology

A multiplex single-cell RNA-Seq pharmacotranscriptomics pipeline for drug discovery

Article

Author: Barker, Harlan ; Sharma, Subodh ; Dini, Alice ; Piki, Emilia ; Raivola, Juuli ; Ungureanu, Daniela ; Murumägi, Astrid

Abstract:

The gene-regulatory dynamics governing drug responses in cancer are yet to be fully understood. Here, we report a pipeline capable of producing high-throughput pharmacotranscriptomic profiling through live-cell barcoding using antibody–oligonucleotide conjugates. This pipeline combines drug screening with 96-plex single-cell RNA sequencing. We show the potential of this approach by exploring the heterogeneous transcriptional landscape of primary high-grade serous ovarian cancer (HGSOC) cells after treatment with 45 drugs, with 13 distinct classes of mechanisms of action. A subset of phosphatidylinositol 3-OH kinase (PI3K), protein kinase B (AKT) and mammalian target of rapamycin (mTOR) inhibitors induced the activation of receptor tyrosine kinases, such as the epithelial growth factor receptor (EGFR), and this was mediated by the upregulation of caveolin 1 (CAV1). This drug resistance feedback loop could be mitigated by the synergistic action of agents targeting PI3K–AKT–mTOR and EGFR for HGSOC with CAV1 and EGFR expression. Using this workflow could enable the personalized testing of patient-derived tumor samples at single-cell resolution.

01 Feb 2025·EXPERIMENTAL NEUROLOGY

PGAM5 promotes RIPK1-PANoptosome activity by phosphorylating and activating RIPK1 to mediate PANoptosis after subarachnoid hemorrhage in rats

Article

Author: Xiaoxin, Yan ; Aihua, Liu ; Jia, Zeng ; Zhen, Fang ; Wen, Yuan ; Fangen, Kong ; Fei, Liu ; Enyan, Jiang ; Jikai, Wang ; Jiajia, Duan ; Xiaojian, Zhang

Neuronal death plays a crucial role in early brain injury after subarachnoid hemorrhage (SAH). PANoptosis is a programmed form of cell death regulated by the PANoptosome, which possesses key characteristics of pyroptosis, apoptosis and necroptosis. Phosphoglycerate mutase family member 5 (PGAM5) has specific phosphatase activity that phosphorylates or dephosphorylates serine and threonine residues on bound proteins such as receptor-interacting protein kinase 1 (RIPK1), which are involved in programmed cell death. This study aimed to explore whether PANoptosis occurs after subarachnoid hemorrhage and to investigate the role of PGAM5 in early brain injury after SAH. A monofilament perforation SAH model in Sprague-Dawley rats was established, and PGAM5 siRNA (siPGAM5) was administered via intracerebroventricular injection 48 h before SAH modeling. The efficacy of siPGAM5 treatment was assessed via neurological scoring, and the impact of siPGAM5 on PANoptosis was evaluated via Western blotting, TUNEL staining and ELISA. To investigate its potential mechanism, the RIPK1 activator birinapant was administered intraperitoneally 0.5 h after SAH. The role of RIPK in PGAM5-mediated PANoptosis was evaluated by Western blotting and coimmunoprecipitation. Our findings indicate that PANoptosis occurs in neurons after SAH and that reducing PGAM5 in the cytosol after SAH can reduce PANoptosis and enhance the short-term and long-term neurological functions of SAH rats. Mechanistically, we discovered that PGAM5 can directly bind to and phosphorylate and activate RIPK1 (ser 166), triggering the assembly of the RIPK1-PANoptosome complex. In conclusion, our study revealed that the increased PGAM5 in the mitochondria-free cytosol after SAH can bind to and activate RIPK1 (ser 166), driving the assembly of the RIPK1-PANoptosome and mediating PANoptosis after SAH. PGAM5 and PANoptosis might be novel therapeutic targets for SAH.

01 Oct 2024·Translational Cancer Research

Article

News (Medical) associated with Birinapant

15 Feb 2024

·www.prnewswire.com

MEDIVIR AB - YEAR-END REPORT JANUARY - DECEMBER 2023

STOCKHOLM, Feb. 15, 2024 /PRNewswire/ -- "The clinical efficacy of fostrox in combination with Lenvima continues to improve with median time to progression having increased to over 6 months" October – December Financial summary for the quarter Net turnover amounted to SEK 4.4 (2.3) million. The loss before interest, tax, depreciation and amortization (EBITDA) amounted to SEK -20.1 (-17.9) million. Basic and diluted earnings per share amounted to SEK -0.28 (-0.32) and SEK -0.28 (-0.32) respectively. Cash flow from operating activities amounted to SEK -4.6 (-24.7) million. Cash and cash equivalents at the end of the period amounted to SEK 169.5 (117.4) million. Significant events during the quarter In October, data from an investigator evaluation showed continued promising tumor control with fostrox + Lenvima in HCC. All patients in the phase 2a study had dosed at least two treatment cycles. In October, the Board of Directors announced that Anette Lindqvist is leaving her position as Board Member of Medivir AB due to personal reasons. In October the nomination committee was appointed ahead of the AGM in May 2024. The Nomination Committee consists of Karl Tobieson, appointed by Linc AB, Richard Torgerson, appointed by Nordea Investment Funds, Anders Hallberg, appointed by HealthInvest Partners and Uli Hacksell, Chairman of the Board, Medivir AB. The Q3 report and the subsequent webcast included in-depth interim data from the 18 patients in the phase 1b/2a study who had a minimum follow-up of 12 weeks. These data continued to demonstrate clear patient benefit for the fostrox + Lenvima combination. In November it was announced that the company's interactions with the FDA regarding fostrox's clinical development plan had intensified with a first Type D meeting with a positive response regarding critical elements of the design for the planned phase 2b study. Late November it was announced that the development of an updated formulation of fostrox, suitable for commercial manufacture, had been finalized. In December, Medivir's partner IGM Biosciences, communicated a strategic pipeline cost-saving prioritization that among other things affects IGM's DR-5-agonist, aplitabart, in combination with birinapant, which was licensed in from Medivir in 2021. In December it was announced that Medivir has signed an agreement with Lonza for the manufacture of fostrox drug substance for the planned phase 2b study. In December it was announced that the durable clinical benefit in the ongoing phase 1b/2a study continues to improve, as data become more mature. In December, a rights issue was carried out, through which the company received proceeds of approximately SEK 129 before deduction of costs attributable to the rights issue. January – December Financial summary for the period Net turnover amounted to SEK 7.6 (4.4) million. The loss before interest, tax, depreciation and amortization (EBITDA) amounted to SEK -88.7 (-84.8) million. Basic and diluted earnings per share amounted to SEK -1.48 (-1.59) and SEK -1.48 (-1.59) respectively. Cash flow from operating activities amounted to SEK -59.7 (-101.8) million. Cash and cash equivalents at the end of the period amounted to SEK 169.5 (117.4) million. Events after the end of the period In January, a directed issue to Hallberg Management AB was carried out amounting to approximately SEK 20 million before deduction of issuance costs. In January, positive data from the ongoing phase 1b/2a study in advanced liver cancer (HCC) showing further improved response and time to progression was presented at the ASCO GI Symposium in San Francisco. In January Tango Therapeutics announced that it has dosed the first patient with TNG348, a new USP1-inhibitor from the preclinical USP1 program inlicensed from Medivir in 2020 Conference call for investors, analysts and the media The Year-End Report January - December 2023 will be presented by Medivir's CEO, Jens Lindberg. Time: Thursday, February 15, 2024, at 14.00 (CET). To access the webcast and find information about the teleconference, please klick HERE! The conference call will also be streamed via a link on the website: . The presentation will be available on Medivir's website after completion of the conference. CEO's message Fostrox in combination with Lenvima continues to show improved efficacy for patients with advanced primary liver cancer (HCC). The data presented in January 2024 at the ASCO-GI congress in San Francisco showed a further increase in the proportion of patients who achieve a clinically relevant reduction of their liver tumor and that patients stay on treatment longer with interrupted tumor growth. These data attracted very strong interest, which makes us even more convinced of fostrox's future role in the treatment of HCC and creates the opportunity for a faster route to market. The unmet medical need in the treatment of advanced HCC is significant. Primary liver cancer is the third leading cause of cancer-related deaths. In today's treatment guidelines, an immunotherapy combination (Tecentriq®/Avastin®) is recommended as first-line treatment. However, when this combination has stopped working, there are no approved alternatives for second-line treatment. There is thus a large need for additional treatment options in second-line that attacks the tumor in different ways compared to what Tecentriq and Avastin does. Fostrox is an organ specific, so-called smart chemotherapy, that selectively kills cancer cells in the liver. Together with Lenvima, these two form a unique combination of complementary drugs that have shown promising interim results in an ongoing phase 1b/2a study, including a complete tumor response in one patient. All patients in the study have now had at least 18 weeks of follow-up. The more mature and in-depth data we see from the study, the more convincing the clinical benefit for patients has become. Data from this study was presented at the ASCO GI Congress on January 19, 2024. These results, evaluated by investigators and local radiologists, showed further improvement as the Overall Response Rate (ORR) had increased to 25% (RECIST 1.1), a notably higher percentage than the 5-10% shown in second-line HCC in previous studies. The update also showed continued good tolerability without any new unexpected side effects. At the time of this quarterly report over 40% of patients remain on treatment in the study, and the clinical efficacy keeps improving. The median time to progression has increased further to 6.3 months, compared to 5.1 months at ASCO GI, significantly better than previous studies in second-line HCC. The patient who has benefited the longest remains on treatment after 18 months with partial response and continued shrinking tumor. Our data was met with great interest at ASCO GI, where we had the opportunity to discuss with leading global experts what the fostrox + Lenvima combination could mean for these patients. The discussions confirmed the great need that exists in the second-line treatment of HCC, where patients are today without any approved treatment alternative. With these promising data, fostrox has the opportunity to become the first approved medicinal treatment in a market worth ~2.5 billion USD annually, through a so-called accelerated approval by the regulatory authorities. We have therefore put in a higher gear in 2023 to ensure maximum momentum in fostrox's development program based on this possibility of accelerated approval. In Q4 2023 the development of an updated, commercially adapted formulation of fostrox was completed. In parallel, we have initiated the process with the FDA for a so-called Type C meeting to discuss the final study design of the planned registrational phase 2b study. In conjunction with these measures, we can now also deepen our discussions with potential partners, in accordance with previously communicated plans. We can also note that several of the projects that Medivir has licensed out to collaboration partners is entering clinical stage. In January 2024, Tango Therapeutics initiated a phase 1/2 study and dosed the first patient with TNG348, a USP-1 inhibitor developed from the preclinical USP1 program that was in-licensed from Medivir in 2020. INFEX Therapeutics also intends to initiate phase 1 study in 2024 - with the preclinical program MBLI, previously in-licensed from Medivir. IGM Biosciences has completed the fifth dose escalation cohort in the company's phase 1 study in solid tumors with Medivir's clinical project birinapant in combination with its own DR5 agonist antibody IGM-8444, now called aplitabart. For Medivir, the clinical development of fostrox is clearly in focus. With the promising data showing further improved clinical efficacy compared to expected treatment results in second-line HCC, we are even more confident that fostrox can become an effective liver cancer drug that makes a real difference to patients. I would like to thank old and new shareholders for the trust in our rights issue and for the capital injection that benefited us in the directed share issue. I look forward to keeping you informed of Medivir's continued development. Jens Lindberg Chief Executive Officer For further information, please contact Magnus Christensen, CFO Phone: +46 (0)8 5468 3100 E-mail: [email protected] This report has not been subject to auditors' review. The information was submitted for publication at 08.30 CET on February 15, 2024 The following files are available for download: SOURCE Medivir

Phase 2Phase 1Financial StatementAccelerated ApprovalClinical Result

06 Dec 2023

·www.fiercebiotech.com

IGM, with cash dipping below $390M, cuts headcount 22%, stops blood cancer work to stretch money

IGM ended September with 290 full-time employees. How much money does a biotech need to feel comfortable in today’s market? IGM Biosciences added to evidence that the number is big after the market closed Tuesday, when it revealed a 22% reduction in its headcount and prioritization of its pipeline to make the hundreds of millions in its bank go further. Talking at an investor event last month, IGM CEO Fred Schwarzer gave an upbeat answer to a question about the biotech’s financial footing, telling attendees that it had “plenty of cash to get through into the second half of 2025.” The cash pile stood at $387 million at the end of September. Yet, while IGM has a bank balance to turn some biotechs green with envy, it has decided it needs to cut costs. IGM ended September with 290 full-time employees. The decision to reduce that figure by 22% is part of a set of changes intended to keep IGM going into the second quarter of 2026. Through the changes, IGM is focusing its resources on colorectal cancer and autoimmune diseases. The biotech is halting work on two assets, the CD123xCD3 bispecific IGM-2537 and IL-15xPD-L1 candidate IGM-7354, and cutting the list of the indications targeted by two other molecules. Work on aplitabart in acute myeloid leukemia and in combination with birinapant is stopping, as is development of IGM-2644 in multiple myeloma. In a statement, Schwarzer said IGM is “very encouraged by the clinical and preclinical data that we have generated for the programs” but is halting work in response to “the difficult conditions in the capital markets for our industry.” The changes are intended to narrow IGM’s focus on opportunities with “the most potential to produce significant near-term value,” the CEO said. IGM will continue to study aplitabart, a DR5 agonist, in colorectal cancer, forging toward the goal of enrolling 110 patients in a randomized trial by the end of the first quarter of next year. Development of the CD38xCD3 bispecific IGM-2644 is continuing in autoimmune diseases. IGM aims to file to test the drug candidate in humans next year. Work on the CD20xCD3 bispecific imvotamab is continuing too.

PROTACsFinancial Statement

06 Dec 2023

·www.prnewswire.com

Medivir's partner IGM Biosciences announces strategic pipeline prioritization to extend its cash runway

STOCKHOLM, Dec. 6, 2023 /PRNewswire/ -- Medivir AB (Nasdaq Stockholm: MVIR) , a pharmaceutical company focused on developing innovative treatments for cancer in areas of high unmet medical need, announced today that its partner, IGM Biosciences, has communicated a strategic pipeline prioritization and reduction of workforce with the key aim of extending its cash runway in a challenging financial climate. In the announcement by IGM, a number of its programs are impacted by this pipeline prioritization, including the combination of IGM's DR-5 agonist, aplitabart and birinapant, which IGM licensed from Medivir in 2021. The combination of aplitabart and birinapant has demonstrated exceptionally strong preclinical synergy across multiple tumor models and has been including patients in the 5th dose escalation cohort, with no dose-limiting toxicities to date. Medivir will discuss with IGM how to maximize the long-term value of birinapant following the announced prioritization. The announcement by IGM has no impact on Medivir's focus and development efforts with its lead program fostroxacitabine bralpamide (fostrox) for the treatment of primary liver cancer (HCC). Medivir continues to maximize the momentum of the fostrox development program as it accelerates a number of critical activities to enable initiation of a pivotal phase 2b study with accelerated approval intent by 2027. If successful outcome of the planned study, fostrox has the potential to become the first approved treatment for HCC patients who have progressed on current first-line standard of care, a market valued at ~$2.5bn annually by 2028. Fostrox is currently being evaluated in an ongoing phase 1b/2a study in combination with Lenvima® in second-line HCC. With all 21 patients now having had minimum 12 weeks follow-up, 81% of the patients show clinical benefit at the first efficacy evaluation with lower than anticipated need for dose modifications due to adverse events. Patients are on average staying longer on treatment than anticipated with ~50% of patients still on treatment and the longest running patient treated for more than 15 months with sustained objective response. For additional information, please contact; Magnus Christensen, CFO, Medivir AB Telephone: +46 8 5468 3100 E-mail: [email protected] About Medivir Medivir develops innovative drugs with a focus on cancer where the unmet medical needs are high. The drug candidates are directed toward indication areas where available therapies are limited or missing and there are great opportunities to offer significant improvements to patients. Medivir is focusing on the development of fostroxacitabine bralpamide (fostrox), a pro-drug designed to selectively treat liver cancer and to minimize side effects. Collaborations and partnerships are important parts of Medivir's business model, and the drug development is conducted either by Medivir or in partnership. Medivir's share (ticker: MVIR) is listed on Nasdaq Stockholm's Small Cap list. . The following files are available for download: SOURCE Medivir

Drug ApprovalPhase 2

100 Deals associated with Birinapant

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KEGG	Wiki	ATC	Drug Bank
D10417	-	-	DB11782

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Fallopian Tube High Grade Serous Adenocarcinoma	Phase 2	United States	TetraLogic Pharmaceuticals Corp.	01 Aug 2018
high grade serous adenocarcinoma of ovary	Phase 2	United States	TetraLogic Pharmaceuticals Corp.	01 Aug 2018
Primary Peritoneal High-Grade Serous Adenocarcinoma	Phase 2	United States	TetraLogic Pharmaceuticals Corp.	01 Aug 2018
Recurrent Primary Peritoneal Carcinoma	Phase 2	United States	TetraLogic Pharmaceuticals Corp.	01 Aug 2018
Malignant neoplasm of gastro-oesophageal junction	Phase 2	United States	Medivir AB	04 Aug 2017
Small Cell Lung Cancer	Phase 2	United States	Medivir AB	04 Aug 2017
Squamous Cell Carcinoma of Head and Neck	Phase 2	United States	Medivir AB	04 Aug 2017
Uterine Cervical Cancer	Phase 2	United States	Medivir AB	04 Aug 2017
Ovarian Cancer	Phase 2	United States	Medivir AB	04 Aug 2017
Hepatitis B	Phase 2	Australia	Medivir AB	23 Oct 2014

Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT03803774 (CTgov)	Phase 1	Recurrent Squamous Cell Carcinoma of the Head and Neck \| Nasopharyngeal Squamous Cell Carcinoma \| Sinonasal Squamous Cell Carcinoma	13	Birinapant (Birinapant 5.6 mg/m^2 & Intensity Modulated Re-Irradiation Therapy (IMRRT) 2 Gray(Gy))	rzpkncfwwo = lejkguykye iaaulnkmnz (sdxiiiwajg, rgledrflzr - rehfcftqdk) View more	-	23 Jul 2024
				Birinapant (Birinapant 11 mg/m^2 & Intensity Modulated Re-Irradiation Therapy (IMRRT) 2 Gray(Gy))	rzpkncfwwo = qdealphixk iaaulnkmnz (sdxiiiwajg, svrqwrcatb - mzvglgangj) View more
NCT01486784 (CTgov)	Phase 1/2	Acute Myeloid Leukemia \| Acute Lymphoblastic Leukemia \| Myelodysplastic Syndromes	27	Birinapant (Phase 1 DL1)	ktshfwvrzz = lvfwwuagop wncdujxpkf (zhnjitnncs, xkcwglcrjm - fmjyvvnyud) View more	-	13 May 2021
				Birinapant (Phase 1 DL-1)	ktshfwvrzz = uuyzxzfqdn wncdujxpkf (zhnjitnncs, hakttogreu - jbiffbkotg) View more
NCT02587962 (BPT-201, CTgov)	Phase 1/2	Ovarian Cancer \| Solid tumor \| Squamous Cell Carcinoma of Head and Neck ... View more	34	birinapant+pembrolizumab (Phase 1 - 5.6 mg)	vjehqrotna(ngnnnixwyv) = gxjulgynqm pagfihhula (gnoafbiabu, 18.6) View more	-	14 Jan 2021
				birinapant+pembrolizumab (Phase 1 - 11 mg)	vjehqrotna(ngnnnixwyv) = wsexjvjfle pagfihhula (gnoafbiabu, 14.5) View more
NCT02587962 (BPT-201, ASCO2019)	Phase 1/2	Solid tumor	34	Birinapant + Pembrolizumab	sysjwivjld(yknjhkvzys) = No cases of Bell's palsy were detected. ozzkzysnfj (skilcrkakd ) View more	Positive	26 May 2019
NCT01188499 (CTgov)	Phase 1/2	Advanced Malignant Solid Neoplasm	176	Carboplatin+TL32711+Paclitaxel (Arm 1: Carboplatin/Paclitaxel + TL32711)	wfydcpizms = wvhnmxrikn vpazgtqgph (iiptvnivek, tdvcyvtrse - ubndztmfub) View more	-	30 May 2016
				TL32711+Irinotecan (Arm 2: Irinotecan + TL32711)	wfydcpizms = ylvcdlakga vpazgtqgph (iiptvnivek, cuxbzvzzua - nfszctfsxo) View more
NCT02147873 (ASCO2016)	Phase 2	High Risk Myelodysplastic Syndrome \| Chronic Myelomonocytic Leukemia	118	5-AZA + Birinapant	uehqqbopny(olojmohvwa) = Serious treatment-emergent adverse events (AEs) were higher in the birinapant arm than placebo arm (61.4% vs. 40.8%) sirtmwdlqh (uxcbbtsqfz ) View more	Negative	20 May 2016
				Placebo
NCT01681368 (Pubmed \| Cancer) Manual	Phase 2	Ovarian Epithelial Carcinoma	11	birinapant	yynneinzzn(alaiksgpxi) = mmvngtlkdo rwcxxfeomj (stqjrjwjxl )	Negative	15 Feb 2016
NCT01681368 (CTgov)	Phase 2	Recurrent ovarian cancer \| Platinum-Resistant Primary Peritoneal Carcinoma \| Ovarian Serous Adenocarcinoma ... View more	11	Birinapant (TL32711)	rpjwbuljkp = fzgqfejibx evbakzgdkb (tlaobzpfru, aasvhaiwow - ppdoqyhggp) View more	-	03 Feb 2015
NCT01188499 (ASCO2013)	Phase 2	Metastatic Colorectal Carcinoma	51	Birinapant + Irinotecan (22mg/m2)	tafhjkhfal(duomziuigx) = nhldjtfbuc ozpxxwpkww (fiejkfuicc ) View more	-	20 May 2013
				Birinapant + Irinotecan (35mg/m2)	tafhjkhfal(uqhwannfco) = sdopxaxmyy evnwyqjynm (wiutxuorre ) View more
NCT01188499 (ASCO2013)	Phase 1	Solid tumor	124	Birinapant	isbwjzrcvx(clodjghvls) = ggtmpmbkza phxhctlgbp (yyvwrghvzc )	-	20 May 2013
				Carboplatin/paclitaxel	isbwjzrcvx(clodjghvls) = cqbxokmetb phxhctlgbp (yyvwrghvzc )

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