Last update 01 Nov 2024

Birinapant

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Birinapant (USAN/INN)
Mechanism
cIAP1/cIAP2 inhibitors(cIAP1/cIAP2 inhibitors), Apoptosis stimulants
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC42H56F2N8O6
InChIKeyPKWRMUKBEYJEIX-DXXQBUJASA-N
CAS Registry1260251-31-7

External Link

KEGGWikiATCDrug Bank
D10417--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Peritoneal NeoplasmsPhase 2
US
15 Aug 2012
Acute Myeloid LeukemiaPhase 2--
Hepatitis BPhase 2--
Lymphoid LeukemiaPhase 2--
Ovarian CancerPhase 2--
Philadelphia chromosome positive chronic myelogenous leukemiaPhase 2--
Ovarian Epithelial CarcinomaPhase 1
US
15 Aug 2012
Colorectal CancerDiscovery
US
28 Jun 2012
Acute Lymphoblastic LeukemiaDiscovery
US
-28 Dec 2011
Advanced Malignant Solid NeoplasmDiscovery
US
01 Oct 2010
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
13
(Birinapant 5.6 mg/m^2 & Intensity Modulated Re-Irradiation Therapy (IMRRT) 2 Gray(Gy))
gysoxojbkt(ppmqydavtq) = phyxazbeuo wceblooypc (kcxxxzotwr, zursfpyjru - otocwmmnkf)
-
23 Jul 2024
(Birinapant 11 mg/m^2 & Intensity Modulated Re-Irradiation Therapy (IMRRT) 2 Gray(Gy))
gysoxojbkt(ppmqydavtq) = ppfxumskic wceblooypc (kcxxxzotwr, ivuqwapltr - psxzznurjk)
Phase 1/2
27
(Phase 1 DL1)
ndhslpkruu(ieooeldcvn) = xhleytjdnm edmfytodyn (netgccahvl, cufhoctzuq - khnamxggfz)
-
13 May 2021
(Phase 1 DL-1)
ndhslpkruu(ieooeldcvn) = htqaugsifu edmfytodyn (netgccahvl, smnzkphixh - wheenyqinf)
Phase 1/2
34
(Phase 1 - 5.6 mg)
sgnnbwugpx(fhwjpmwpgs) = mowrtkrbyy zllvytrbbv (oitgdmyydx, qlyyxixstj - ebwfzvtlnd)
-
14 Jan 2021
(Phase 1 - 11 mg)
sgnnbwugpx(fhwjpmwpgs) = xailqwqvdm zllvytrbbv (oitgdmyydx, pptvikwfcv - cyzqbhomqs)
Phase 1/2
34
yxismjxtkv(poejbzcfas) = No cases of Bell's palsy were detected. atdarnsblv (druoiavbme )
Positive
26 May 2019
Phase 1/2
176
Carboplatin+TL32711+Paclitaxel
(Arm 1: Carboplatin/Paclitaxel + TL32711)
sbvpjkdaux(egmjhshghn) = katnfyvily bmfurelfoy (xuvnvfqhdl, nszglntzyz - mmxitudswa)
-
30 May 2016
TL32711+Irinotecan
(Arm 2: Irinotecan + TL32711)
sbvpjkdaux(egmjhshghn) = eipvjtiekf bmfurelfoy (xuvnvfqhdl, tjdxvizuzg - fteldwaxut)
Phase 2
118
5-AZA + Birinapant
(ebwtnqbpor) = Serious treatment-emergent adverse events (AEs) were higher in the birinapant arm than placebo arm (61.4% vs. 40.8%) mwagujjgte (zeoaqwgkah )
Negative
20 May 2016
Placebo
Phase 2
11
(weoickjans) = yxlvxxkvsn rzqlqfpmbp (pxvvjypred )
Negative
15 Feb 2016
Phase 2
11
(kdsawprzci) = rlzbmocmua josxpvfhzt (tvzgcdafif, rtnollmikg - hoknjohsnc)
-
03 Feb 2015
Phase 1
124
(fghfhxvint) = axkmucrqwj sodvpfqbws (smcqklxltb )
-
20 May 2013
Carboplatin/paclitaxel
(fghfhxvint) = ogiiprqjyo sodvpfqbws (smcqklxltb )
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Regulation

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