Delving into the Latest Updates on Chung-Pa-Juhn with Synapse

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

GCSB, Shinbaro

+ [1]

Target

MMPs

Action

inhibitors

Mechanism

MMPs inhibitors(Matrix metalloproteinase inhibitors)

Therapeutic Areas

Skin and Musculoskeletal Diseases

Active Indication

Osteoarthritis

Inactive Indication-

Originator Organization

Green Cross Holdings Corp.

Active Organization

Green Cross Holdings Corp.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

South Korea (23 Apr 2014),

Osteoarthritis

Regulation-

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GCSB-5 ("Shinbaro capsule"), is a mixture of 6 oriental herbs that have anti-inflammatory and analgesic effects along with an excellent safety profile. This study is aimed at investigating efficacy of Shinbaro in the treatment of hand osteoarthritis which needs a long term treatment in a placebo controlled, double-blind randomized trial.

Start Date01 Sep 2013

Sponsor / Collaborator

Seoul National University Hospital

[+1]

NCT01604239

/ CompletedPhase 4

A 24 Weeks, Multi-centers, Single Arm Phase IV Study to Evaluate the Safety of 'Shinbaro Capsule' Compared With Historical Data of 'Celebrex Capsule' in Patients With Osteoarthritis

This study investigates if Shinbaro capsule has a lower incident of gastrointestinal events than celecoxib in subjects with osteoarthritis.

Start Date01 May 2012

Sponsor / Collaborator

Green Cross Co., Ltd.

NCT01535417

/ CompletedPhase 3

A 12 Weeks, Randomized, Double-blind, Multi-centers, Phase III Study to Evaluate the Efficacy and Safety of Shinbaro Capsule Compared With Celebrex Capsule in Patients With Osteoarthritis of Knee

The purpose of this study is to evaluate the efficacy and safety of 'Shinbaro Capsule', a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee.

Start Date01 May 2009

Sponsor / Collaborator

Green Cross Co., Ltd.

100 Clinical Results associated with Chung-Pa-Juhn

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100 Translational Medicine associated with Chung-Pa-Juhn

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100 Patents (Medical) associated with Chung-Pa-Juhn

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18

Literatures (Medical) associated with Chung-Pa-Juhn

01 Feb 2024·Current Rheumatology Reviews

Efficacy of Herbal Medicine in Hand Osteoarthritis: A Narrative Review

Review

Author: Noorabadi, Parisa ; Aghili, Seyedeh Mehrnaz ; Sahebari, Maryam ; Salari, Masoumeh

Objective:Osteoarthritis (OA) is one of the most prevalent joint disorders in the world that has placed an enormous economic and social burden on governments and healthcare sectors in many countries. Hand OA (HOA) is the most common peripheral arthritis, which is less investigated than knee and hip OA. Due to limited approved drug choices and adverse effects of long-term use of current regimens, we aimed to review the existing evidence that were used as oral herbal medicine to treat HOA.Methods:The PubMed database was searched for both observational and interventional studies that have investigated herbal medicine safety and efficacy in HOA, written in English and published between 2010 and 2022.Results:A total of 5 original articles fulfilled the inclusion criteria, and each article assessed a different herbal regimen. Overall, it seems desirable to add specific herbal treatments to the regimen of HOA patients, specifically in case of early stages of HOA.Conclusion:Currently, the need for a low-risk alternative treatment in HOA patients is felt more than ever. There are reliable references relating to the safety of Korean red ginseng, GCSB-5, XLGB, and GS-GCu in these patients, although their efficacy was limited. Additionally, herbs like curcumin and Boswellia serrata have positively affected patients with knee osteoarthritis. However, there is a lack of strong evidence supporting their effectiveness in hand osteoarthritis (HOA). This emphasizes the potential benefits that these herbs may have for HOA patients.

01 Dec 2023·Archives of Rheumatology

GCSB-5 regulates inflammatory arthritis and pain by modulating the mitogen-activated protein kinase signaling pathway in a murine model of rheumatoid arthritis

Article

Author: Young Park, Soo ; Bang, Jihye ; Kim, Sang-Hyon ; Kim, Gyeonghwa ; Kim, Ji-Min ; Jung, Hye Ra

Objectives: This study aimed to determine whether GCSB-5 has anti-inflammatory and antinociceptive effects in mice with collagen-induced arthritis (CIA), an animal model of rheumatoid arthritis (RA), and investigate the influence of GCSB-5 on the mitogen-activated protein kinase (MAPK) pathway.Materials and methods: The experimental animal study was designed to include five groups: CIA mice treated with GCSB-5 (300 mg/kg), GCSB-5 (600 mg/kg), celecoxib (60 mg/kg), or saline for four weeks, and nontreated control mice. The clinical severity of arthritis was scored. Nociceptive thresholds were measured by using a von Frey dynamic plantar analgesimeter. The MAPK pathway was evaluated in mouse synovium. The expression of channels associated with pain signaling was assessed by western blot and immunohistochemical staining.Results: GCSB-5 treatment diminished the severity of clinical arthritis and increased the nociceptive threshold in mice with CIA. Celecoxib, a positive control drug, also showed comparable changes. Clinical arthritis scores were inversely related to mechanical thresholds. GCSB-5 administration decreased the levels of anti-type II collagen antibody and inflammatory cytokines in the sera of mice with CIA. Furthermore, ERK, p38 MAPK, and JNK phosphorylation were downregulated and TRPV1 and ASIC3 expression were decreased in the synovium of GCSB-5-treated mice compared to salinetreated mice. Interleukin-6-induced TRPV1 and ASIC3 upregulation were also inhibited by GCSB-5 in human RA fibroblast-like synoviocytes in vitro.Conclusion: GCSB-5 decreased inflammatory arthritis and pain in a murine model of RA. The results present evidence that GCSB-5 may be beneficial for relieving pain as well as decreasing inflammation in autoimmune arthritis, such as RA.

01 Jan 2023·Chemosphere

Vitamin C modified crayfish shells biochar efficiently remove tetracycline from water: A good medicine for water restoration

Article

Author: Dai, Yingjie ; Jiang, Huating

In this study, crayfish shell biochar (CSB) was modified by introducing vitamin C (VC) with abundant surface functional groups. CSB was impregnated with VC at different ratios and its capacity to adsorb tetracycline (TC) from water was analyzed. The physicochemical properties of CSB were determined by N₂ adsorption-desorption isotherm analysis, X-ray diffraction, and Fourier transform infrared spectroscopy. The effects of various factors on adsorption such as the pH, TC concentration, time, and salt ion concentrations were also investigated. Based on the chemical structure of VC, VC can provide CSB with more oxygen-containing functional groups such as hydroxyl groups. The results showed that the CSB modified with VC (CSB-VC) exhibited excellent adsorption of TC, and CSB-VC₂ with an impregnation ratio of 2 (gVC/gCSB) had the greatest adsorption performance (saturated adsorption capacity, Q_m = 293.36 mg/g), whereas the adsorption performance of CSB alone was about 50% lower (Q_m = 172.16 mg/g). The optimal impregnation ratio VC improved the adsorption performance of CSB after modification to 70.4% of the original. Hydrogen bonding, p-p conjugation, pi-pi electron donor-acceptor effect, and π-π interactions were identified as the main adsorption mechanisms. CSB-VC₂ was highly effective over a wide range of pH values and at high ion concentrations. Experiments demonstrated the effective regeneration of the adsorbent after multiple cycles, thereby indicating its excellent reusability. It should be noted that the adsorption capacity was good under different water quality conditions, and thus it should exhibit stable adsorption performance under complex water environment conditions.

100 Deals associated with Chung-Pa-Juhn

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External Link

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Osteoarthritis	South Korea	Green Cross Holdings Corp.	23 Apr 2014

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01604239 (Pubmed \| J Ethnopharmacol)	Phase 4	Osteoarthritis	761	GCSB-5	ezotbpjfbd(qoatcnmgro) = fbmnqnhame uksnbepabf (glpwvbgulh )	Positive	02 Aug 2016
NCT01910116 (Pubmed \| Med Lett Drugs Ther \| Clin Ther) Manual	Phase 2/3	Osteoarthritis	215	GCSB-5	(dsmliybrbw) = nvkacnmyse qgyxagbdsp (nmzsfmqijm ) View more	Positive	01 Aug 2016
				Placebo	(dsmliybrbw) = fuceqabngq qgyxagbdsp (nmzsfmqijm ) View more
NCT01910116 (CTgov)	Phase 2/3	Osteoarthritis	220	Shinbaro (Shinbaro)	tolgcjngbv(teyaendlji) = exorrjrulw tdlfmhnlam (pgmbpeogzb, pxsjhzshyf - feieabvsfy) View more	-	17 Dec 2015
				Placebo (Placebo)	tolgcjngbv(teyaendlji) = iwioprcboa tdlfmhnlam (pgmbpeogzb, dfhvafqqss - sjvdbwuzel) View more
NCT01910116 (EULAR2015)	Phase 2/3	Osteoarthritis	-	GCSB-5 600 mg	(jwmrxlwguh) = gqgnydlmoa biwkhoykuu (hlhuqgljha, -23.8 to -0.2) View more	Positive	10 Jun 2015
				Placebo	(jwmrxlwguh) = smhcvffcpw biwkhoykuu (hlhuqgljha, -16.7 to 6.0) View more