Delving into the Latest Updates on NACOS-6 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

NACOS 7

Target-

Mechanism-

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Ihara Chemical Industry Co., Ltd.

Active Organization-

Inactive Organization

Ihara Chemical Industry Co., Ltd.

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

We conducted a comparative study of the protective effects of chitin, chitosan, and N-acetyl chitohexaose (NACOS-6) against mice infected intravenously or intraperitoneally with Pseudomonas aeruginosa and Listeria monocytogenes. Mice pretreated with chitin, chitosan, and NACOS-6 showed resistance to intraperitoneal infections by both microbes. Only mice pretreated with chitin and chitosan showed resistance to intravenous infections by both microbes. The number, active oxygen generation, and myeloperoxidase activity of peritoneal exudate cells (PEC) in the chitin, chitosan, and NACOS-6-treated mice were greater than those of the untreated mice. Also, these PEC factors from mice pretreated with chitin and chitosan were greater than those from the NACOS-6-treated mice.

01 Jan 1988·Chemical and Pharmaceutical BulletinQ4 · MEDICINE

Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor.

Q4 · MEDICINE

Article

Author: S Suzuki ; N Tatewaki ; T Mikami ; M Suzuki ; K Suzuki ; A Tokoro

Two oligosaccharides, hexa-N-acetylchitohexaose (NACOS-6) and chitohexaose (COS-6), consisting solely of N-acetyl-D-glucosamine and D-glucosamine, resp., were growth-inhibitory against Meth-A solid tumor transplanted into BALB/c mice, when each oligosaccharide was administered i.v. at a dose of >1 mg/kg.Mouse peritoneal macrophages elicited with casein underwent activation with these oligosaccharides in vitro to produce interleukin 1.Spleen cells from mice given these oligosaccharides also underwent acceleration of interleukin 2 production and cytolytic T-lymphocyte differentiation.Antitumor mechanism of NACOS-6 and COS-6 are proposed.

100 Deals associated with NACOS-6

Login to view more data