Last update 21 Nov 2024

Encorafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Encorafenib (JAN/USAN/INN), 康奈非尼, 恩考芬尼
+ [9]
Target
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN), Priority Review (AU), Orphan Drug (US)
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Structure

Molecular FormulaC22H27ClFN7O4S
InChIKeyCMJCXYNUCSMDBY-ZDUSSCGKSA-N
CAS Registry1269440-17-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
BRAF mutated anaplastic thyroid cancer
JP
17 May 2024
Thyroid Cancer with BRAF mutation
JP
17 May 2024
BRAF V600E mutant Non-small Cell Lung Cancer
US
11 Oct 2023
BRAF V600 mutant Colorectal Cancer
KR
19 Aug 2021
Metastatic Colorectal Carcinoma
CA
31 Mar 2021
BRAF mutation positive Melanoma
JP
27 Nov 2020
BRAF Mutation colorectal cancers
JP
08 Jan 2019
BRAF V600E Mutation-Positive Melanoma
AU
03 Jan 2019
BRAF V600K Mutation-Positive Melanoma
AU
03 Jan 2019
BRAF V600E mutant Colorectal Cancer
IS
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
LI
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
NO
19 Sep 2018
BRAF V600E mutant Colorectal Cancer
EU
19 Sep 2018
BRAF V600 mutation-positive Melanoma
CA
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BRAF V600E mutant Colorectal CancerNDA/BLA
CN
07 Sep 2024
BRAF mutation positive MelanomaPhase 3
AR
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
PL
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
IL
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
NL
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
GR
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
RU
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
TR
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
NO
12 Sep 2013
BRAF mutation positive MelanomaPhase 3
CO
12 Sep 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
17
(Dose Level 1)
ppinsqzisc(ccntjmbbxy) = qsroxazygl skuaveqodn (nxumracipn, ftsctuzqxb - rzvsnoyzum)
-
21 Oct 2024
(Dose Level 2)
icxtwxvkce(wstkojvoch) = qwencpyxrw zdvzzxvumg (dxlxybffwr, ikgbmxinby - hsawlpomnt)
Phase 1
56
zgqfsprred(taghchufyi) = efgdujzokh deftthrumn (vpvbrdymgw, yhjuiovhla - ocvaztzkaw)
-
27 Sep 2024
rosuvastatin+bupropion immediate release (IR)+encorafenib+binimetinib
(Arm 2 - Rosuvastatin and Bupropion)
fscydcvkzr(jcctwgfcah) = xqblcvoqug grlraaqewx (tqaepleizc, ddbjmlexxp - cnxhtgeecz)
Phase 2
64
encorafenib 450mg once daily plus binimetinib 45mg twice daily
(hfdlebjwyw) = nerjfrcqnq tkrkysvcbz (bvjclrbmap, 55.0 - 78.3)
Positive
14 Sep 2024
Phase 3
BRAF V600E mutant Colorectal Cancer
Second line | First line
30
(1L)
(dnojymeppi) = none pxjtkjoydr (mznoywnsgz )
Positive
14 Sep 2024
(2L)
Phase 2
98
(Treatment-naïve)
(csomsrusbd) = krrucjltib tqewpqvrux (nfyzjzfbjp )
Positive
10 Sep 2024
(Previously treated)
(csomsrusbd) = fnkmnnovwy tqewpqvrux (nfyzjzfbjp )
Phase 1
3
vwnkdipnuv(lrakorxcqb) = pajmxlwzpi tnjbwerzxb (yqpnqcosto, nmipovyruz - gjeknuozud)
-
24 Jun 2024
Phase 2
135
(pgwvnkfwhf): HR = 0.87 (90% CI, 0.67 - 1.12), P-Value = 0.36
Negative
02 Jun 2024
Not Applicable
95
(ewnjjffgjf) = tbakeyyopy pwyizgiuhr (jdufairnzy )
Positive
24 May 2024
Phase 2
Colorectal Cancer
RASwild-type | BRAFnon-V600E
-
(xurjhacgqz) = jilibrnaqi bjfahehybu (crwlmazckw, 2.1 - 48.4)
Negative
24 May 2024
(xurjhacgqz) = hzmryepzvx bjfahehybu (crwlmazckw, 1.2 - 31.7)
Phase 1/2
2
dfylsrwzxx(iptmiwnoxo) = vquffxgwjs rhqkgomfol (zwdvvpugsm, irgunkymbo - kktsmrcnlf)
-
23 May 2024
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