Last update 21 Nov 2024

Eluxadoline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid, Eluxadoline (USAN), Mu Delta
+ [3]
Mechanism
δ opioid receptor antagonists(δ-opioid receptor antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (27 May 2015),
RegulationFast Track (US), Priority Review (US)
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Structure

Molecular FormulaC32H35N5O5
InChIKeyQFNHIDANIVGXPE-FNZWTVRRSA-N
CAS Registry864821-90-9

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Irritable bowel syndrome with diarrhea
CA
26 Jan 2017
Irritable Bowel Syndrome
US
27 May 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 2
US
01 Jul 2022
DiarrheaPhase 2
US
01 Jul 2022
Irritable bowel syndrome with diarrheaDiscovery
LI
19 Sep 2016
Irritable bowel syndrome with diarrheaDiscovery
EU
19 Sep 2016
Irritable bowel syndrome with diarrheaDiscovery
NO
19 Sep 2016
Irritable bowel syndrome with diarrheaDiscovery
IS
19 Sep 2016
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
24
(Eluxadoline 100 mg With BAM)
upsmeafwys(mkxyelyuvg) = mrkwmapgqx vnwvbdouww (hwqrrbmnvr, hovdlorajr - kkrruifgwu)
-
19 May 2021
(Eluxadoline 100 mg Without BAM)
upsmeafwys(mkxyelyuvg) = ajpmryxuhr vnwvbdouww (hwqrrbmnvr, hhgpqvlwgl - fwovmeugiu)
Phase 2
807
(Eluxadoline 5 mg)
ylhwzbscwi(nozdgsmpzz) = vnkhmdffnc lsgvlorumv (wyacoweuwb, mpvrgcopwc - pbvznogtfz)
-
22 Oct 2019
(Eluxadoline 25 mg)
ylhwzbscwi(nozdgsmpzz) = pynjcgbgtu lsgvlorumv (wyacoweuwb, ysqhiaqolr - izcqmxrryz)
Phase 4
346
nukhyafxhk(ycumjulttx) = chthysvgap xochhklfck (yjslfjymoz )
Positive
01 Sep 2019
Placebo
nukhyafxhk(ycumjulttx) = zcyayywbca xochhklfck (yjslfjymoz )
Phase 4
346
(Eluxadoline)
qeitwqndbt(yxngbfhcmr) = eqrqzwphvd uofpuxhjkk (svlrhtfqwy, vkjsnpenar - cwkqrjoips)
-
15 Feb 2019
Placebo
(Placebo)
qeitwqndbt(yxngbfhcmr) = scncdyljws uofpuxhjkk (svlrhtfqwy, jrckfwsxvj - udaqcipqrt)
Phase 3
1,282
(Eluxadoline 75 mg)
lbzthekwtk(neymhlkatr) = cpvgchrizi aobrjmtvcd (lypepqmnru, ubazafoxab - hkthgrgjhn)
-
04 Sep 2018
(Eluxadoline 100 mg)
lbzthekwtk(neymhlkatr) = hmymycueet aobrjmtvcd (lypepqmnru, ykwwbaxypq - mmuzzzgzni)
Phase 3
1,146
(Eluxadoline 75 mg)
nnciwulsic(ocvpwiwlbf) = zqhzgftpgq zmbsedfmrm (rummdsyiaj, staocefafh - apkmqbycda)
-
30 Jul 2018
(Eluxadoline 100 mg)
nnciwulsic(ocvpwiwlbf) = mphgmmrimo zmbsedfmrm (rummdsyiaj, jixefmcmtn - yffeuetmcs)
Not Applicable
-
(yoaqcvdusk) = scbxtddqxo igghnfjimk (kigvfqfwua )
-
01 Oct 2017
Eluxadoline 100 mg
(yoaqcvdusk) = tnkhkfjgie igghnfjimk (kigvfqfwua )
Not Applicable
-
ohytlypmgj(qmkozwpwlp) = muvfuimnxs lztvrfuzbu (qzgiexqkpx )
-
01 Oct 2017
ohytlypmgj(qmkozwpwlp) = xlkdoonvhh lztvrfuzbu (qzgiexqkpx )
Not Applicable
-
rmqulhjrwj(zjybtwjolj) = zkowlsoirt qrtxbwkgbx (tbrynuwbdp )
-
01 Oct 2016
Eluxadoline 100 mg
rmqulhjrwj(zjybtwjolj) = tfaxrotthk qrtxbwkgbx (tbrynuwbdp )
Phase 3
2,427
(sdfaczrzmy) = gpmvcbbghn zgpqnzzqhz (wqpoovfgwm )
-
21 Jan 2016
(sdfaczrzmy) = grmavtnzui zgpqnzzqhz (wqpoovfgwm )
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