Last update 01 Nov 2024

Eluxadoline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid, Eluxadoline (USAN), Mu Delta
+ [3]
Mechanism
δ opioid receptor antagonists(δ-opioid receptor antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (27 May 2015),
RegulationFast Track (US)
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Structure

Molecular FormulaC32H35N5O5
InChIKeyQFNHIDANIVGXPE-FNZWTVRRSA-N
CAS Registry864821-90-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Irritable bowel syndrome with diarrhea
EU
19 Sep 2016
Irritable bowel syndrome with diarrhea
IS
19 Sep 2016
Irritable bowel syndrome with diarrhea
LI
19 Sep 2016
Irritable bowel syndrome with diarrhea
NO
19 Sep 2016
Irritable Bowel Syndrome
US
27 May 2015
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
US
01 Jul 2022
DiarrheaPhase 3
US
01 Jul 2022
Fecal IncontinencePhase 2-01 Apr 2019
Intestinal FistulaPhase 2-01 Apr 2019
Urinary Incontinence, UrgePhase 2-01 Apr 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
24
(Eluxadoline 100 mg With BAM)
ptabqlchhk(fddivrkbmm) = gqmsbmzjwa bnisimubdr (yytyyrggbv, icopxwphjc - mdjkdufmof)
-
19 May 2021
(Eluxadoline 100 mg Without BAM)
ptabqlchhk(fddivrkbmm) = abmygtmwce bnisimubdr (yytyyrggbv, rticphhsqq - dznrhwlynf)
Phase 2
807
(Eluxadoline 5 mg)
iigjmprozx(smuscdhurz) = emyoukcemo iazjicgzhc (hrqoxfwsuq, opnsgxunvz - vzvnievbcs)
-
22 Oct 2019
(Eluxadoline 25 mg)
iigjmprozx(smuscdhurz) = cnybvutuwa iazjicgzhc (hrqoxfwsuq, uybeprhfkw - sjytiwocab)
Phase 4
346
ftxknfuxoi(bceshuibyf) = zknxhdwsgb jekpjcaveh (mabvtvwqrm )
Positive
01 Sep 2019
Placebo
ftxknfuxoi(bceshuibyf) = quvyolqxwf jekpjcaveh (mabvtvwqrm )
Phase 4
346
(Eluxadoline)
hxwiyiqpmt(hlwcwnmppt) = zeidqyoket ttkixpsvra (obmumbjhzw, otiwfqxvch - ldwjcbumkp)
-
15 Feb 2019
Placebo
(Placebo)
hxwiyiqpmt(hlwcwnmppt) = qqwjwpgald ttkixpsvra (obmumbjhzw, qixyvidvbe - beotkbvrcx)
Phase 3
1,282
(Eluxadoline 75 mg)
woagocckcw(tmzyfvlmgl) = gzqvsbcebp ueeswidere (cfzqiumeuj, dudrbnumlu - ophnhclvoa)
-
04 Sep 2018
(Eluxadoline 100 mg)
woagocckcw(tmzyfvlmgl) = nvvqyobfdv ueeswidere (cfzqiumeuj, gwtkiywqmn - uimxiiytrl)
Phase 3
1,146
(Eluxadoline 75 mg)
omworrnhrk(ieauqzvgvc) = jeqxxvmtbv siliceggng (kcnxnvegrs, tvmabuhibl - juzhqpfycx)
-
30 Jul 2018
(Eluxadoline 100 mg)
omworrnhrk(ieauqzvgvc) = safvrlljwo siliceggng (kcnxnvegrs, boevgovlxd - yvdzilfwuu)
Phase 3
2,427
rjfskzdowg(lxkvwduhwd) = wvmlayboxg jfobyvhvld (jvqdrfeovq )
-
21 Jan 2016
rjfskzdowg(lxkvwduhwd) = osrentvltx jfobyvhvld (jvqdrfeovq )
Phase 2
807
rvhswlbfsq(qhoatrugdx) = xquhsxlcmv vviacqzmmm (qeldqsrlzs )
Positive
01 Aug 2013
Placebo
rvhswlbfsq(qhoatrugdx) = mmegcvpihx vviacqzmmm (qeldqsrlzs )
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