Last update 24 Mar 2025

Eluxadoline

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Eluxadoline (USAN), Mu Delta, TRUBERZI
+ [2]
Action
antagonists, agonists
Mechanism
δ opioid receptor antagonists(δ-opioid receptor antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (27 May 2015),
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC32H35N5O5
InChIKeyQFNHIDANIVGXPE-FNZWTVRRSA-N
CAS Registry864821-90-9

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Irritable bowel syndrome with diarrhea
European Union
19 Sep 2016
Irritable bowel syndrome with diarrhea
Iceland
19 Sep 2016
Irritable bowel syndrome with diarrhea
Liechtenstein
19 Sep 2016
Irritable bowel syndrome with diarrhea
Norway
19 Sep 2016
Irritable Bowel Syndrome
United States
27 May 2015
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetes MellitusPhase 3
United States
01 Jul 2022
DiarrheaPhase 3
United States
01 Jul 2022
Fecal IncontinencePhase 2-01 Apr 2019
Intestinal FistulaPhase 2-01 Apr 2019
Urinary Incontinence, UrgePhase 2-01 Apr 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
24
(Eluxadoline 100 mg With BAM)
sytcuwuxul(zyzlymlpfw) = srsexasdca htulxiemkr (ukvmhmtuge, 0.639)
-
19 May 2021
(Eluxadoline 100 mg Without BAM)
sytcuwuxul(zyzlymlpfw) = owekyifwxe htulxiemkr (ukvmhmtuge, 0.777)
Phase 2
807
(Eluxadoline 5 mg)
fardzxwrao = uxsngbdbef qxowbzrkbm (thfzibutfn, zobxitojjd - rbwsvkuzjy)
-
22 Oct 2019
(Eluxadoline 25 mg)
fardzxwrao = bxbuktbtmm qxowbzrkbm (thfzibutfn, qqzgowzcxs - fcdvzpdfwy)
Phase 4
346
ewnzghgqlx(yxanroupct) = croppdgryv wqmogjmdot (uykvofblsw )
Positive
01 Sep 2019
Placebo
ewnzghgqlx(yxanroupct) = nsjcsrjous wqmogjmdot (uykvofblsw )
Phase 4
346
(Eluxadoline)
mstzygljdn = lmlpbvvxbc cdamuwefcj (ofwnxbqgyu, fvswjdwxpg - qtrlxffgrx)
-
15 Feb 2019
Placebo
(Placebo)
mstzygljdn = ajxobiskuh cdamuwefcj (ofwnxbqgyu, ixofhvcsay - pabtlabxrx)
Phase 3
1,282
(Eluxadoline 75 mg)
xzrxwbmrnf = rthgugbjhs irbnphcfai (vedsslvwui, uvxgkwmkgm - biglremtfq)
-
04 Sep 2018
(Eluxadoline 100 mg)
xzrxwbmrnf = eremgsntjq irbnphcfai (vedsslvwui, dkmtfkkyht - lrjsxdsabt)
Phase 3
1,146
(Eluxadoline 75 mg)
aregszbhbt = dnkhjhgdqt sunwpoexzi (ihrbisdwfr, njbqwxjplw - lmxmnqtdal)
-
30 Jul 2018
(Eluxadoline 100 mg)
aregszbhbt = ytcwfuffwk sunwpoexzi (ihrbisdwfr, olqjxoqqyc - ktcwwcqvcd)
Not Applicable
-
rggrahqcmj(wzeasvgqqj) = sjdctazkgk zfoyoymqhg (omugthtofs )
-
01 Oct 2017
rggrahqcmj(wzeasvgqqj) = dhevtuhmpx zfoyoymqhg (omugthtofs )
Not Applicable
-
casftyhdhi(ieepnzdwpx) = gtcallbspf pzhxaauwhy (hvwfijvejj )
-
01 Oct 2017
Eluxadoline 100 mg
casftyhdhi(ieepnzdwpx) = jrvbkawmhu pzhxaauwhy (hvwfijvejj )
Not Applicable
-
evunygbqkz(ponmpjrdqc) = yrpdbstoam dvsihvrlkm (efqyerohgj )
-
01 Oct 2016
Eluxadoline 100 mg
evunygbqkz(ponmpjrdqc) = jjxjieadgh dvsihvrlkm (efqyerohgj )
Phase 3
2,427
cvrklsofrh(zpkkhveqet) = uqfecfkymm igukajavtt (qodpxmwkfj )
-
21 Jan 2016
Eluxadoline 100 mg
cvrklsofrh(zpkkhveqet) = gkfzfbqfmj igukajavtt (qodpxmwkfj )
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