Drug Type Small molecule drug |
Synonyms Eluxadoline (USAN), Mu Delta, TRUBERZI + [2] |
Action antagonists, agonists |
Mechanism δ opioid receptor antagonists(δ-opioid receptor antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
Drug Highest PhaseApproved |
First Approval Date United States (27 May 2015), |
RegulationFast Track (United States) |
Molecular FormulaC32H35N5O5 |
InChIKeyQFNHIDANIVGXPE-FNZWTVRRSA-N |
CAS Registry864821-90-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10403 | Eluxadoline |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Irritable bowel syndrome with diarrhea | European Union | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Iceland | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Liechtenstein | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Norway | 19 Sep 2016 | |
Irritable Bowel Syndrome | United States | 27 May 2015 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus | Phase 3 | United States | 01 Jul 2022 | |
Diarrhea | Phase 3 | United States | 01 Jul 2022 | |
Fecal Incontinence | Phase 2 | - | 01 Apr 2019 | |
Intestinal Fistula | Phase 2 | - | 01 Apr 2019 | |
Urinary Incontinence, Urge | Phase 2 | - | 01 Apr 2019 |
Phase 4 | 24 | (Eluxadoline 100 mg With BAM) | sytcuwuxul(zyzlymlpfw) = srsexasdca htulxiemkr (ukvmhmtuge, 0.639) View more | - | 19 May 2021 | ||
(Eluxadoline 100 mg Without BAM) | sytcuwuxul(zyzlymlpfw) = owekyifwxe htulxiemkr (ukvmhmtuge, 0.777) View more | ||||||
Phase 2 | 807 | (Eluxadoline 5 mg) | fardzxwrao = uxsngbdbef qxowbzrkbm (thfzibutfn, zobxitojjd - rbwsvkuzjy) View more | - | 22 Oct 2019 | ||
(Eluxadoline 25 mg) | fardzxwrao = bxbuktbtmm qxowbzrkbm (thfzibutfn, qqzgowzcxs - fcdvzpdfwy) View more | ||||||
Phase 4 | 346 | ewnzghgqlx(yxanroupct) = croppdgryv wqmogjmdot (uykvofblsw ) View more | Positive | 01 Sep 2019 | |||
Placebo | ewnzghgqlx(yxanroupct) = nsjcsrjous wqmogjmdot (uykvofblsw ) View more | ||||||
Phase 4 | 346 | (Eluxadoline) | mstzygljdn = lmlpbvvxbc cdamuwefcj (ofwnxbqgyu, fvswjdwxpg - qtrlxffgrx) View more | - | 15 Feb 2019 | ||
Placebo (Placebo) | mstzygljdn = ajxobiskuh cdamuwefcj (ofwnxbqgyu, ixofhvcsay - pabtlabxrx) View more | ||||||
Phase 3 | 1,282 | (Eluxadoline 75 mg) | xzrxwbmrnf = rthgugbjhs irbnphcfai (vedsslvwui, uvxgkwmkgm - biglremtfq) View more | - | 04 Sep 2018 | ||
(Eluxadoline 100 mg) | xzrxwbmrnf = eremgsntjq irbnphcfai (vedsslvwui, dkmtfkkyht - lrjsxdsabt) View more | ||||||
Phase 3 | 1,146 | (Eluxadoline 75 mg) | aregszbhbt = dnkhjhgdqt sunwpoexzi (ihrbisdwfr, njbqwxjplw - lmxmnqtdal) View more | - | 30 Jul 2018 | ||
(Eluxadoline 100 mg) | aregszbhbt = ytcwfuffwk sunwpoexzi (ihrbisdwfr, olqjxoqqyc - ktcwwcqvcd) View more | ||||||
Not Applicable | - | rggrahqcmj(wzeasvgqqj) = sjdctazkgk zfoyoymqhg (omugthtofs ) | - | 01 Oct 2017 | |||
rggrahqcmj(wzeasvgqqj) = dhevtuhmpx zfoyoymqhg (omugthtofs ) | |||||||
Not Applicable | - | casftyhdhi(ieepnzdwpx) = gtcallbspf pzhxaauwhy (hvwfijvejj ) | - | 01 Oct 2017 | |||
Eluxadoline 100 mg | casftyhdhi(ieepnzdwpx) = jrvbkawmhu pzhxaauwhy (hvwfijvejj ) | ||||||
Not Applicable | - | evunygbqkz(ponmpjrdqc) = yrpdbstoam dvsihvrlkm (efqyerohgj ) View more | - | 01 Oct 2016 | |||
Eluxadoline 100 mg | evunygbqkz(ponmpjrdqc) = jjxjieadgh dvsihvrlkm (efqyerohgj ) View more | ||||||
Phase 3 | 2,427 | cvrklsofrh(zpkkhveqet) = uqfecfkymm igukajavtt (qodpxmwkfj ) View more | - | 21 Jan 2016 | |||
Eluxadoline 100 mg | cvrklsofrh(zpkkhveqet) = gkfzfbqfmj igukajavtt (qodpxmwkfj ) View more |