Drug Type Small molecule drug |
Synonyms 5-({(4-carbamoyl-2,6-dimethyl-L-phenylalanyl)[(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]amino}methyl)-2-methoxybenzoic acid, Eluxadoline (USAN), Mu Delta + [3] |
Mechanism δ opioid receptor antagonists(δ-opioid receptor antagonists), κ opioid receptor agonists(Kappa opioid receptor agonists), μ opioid receptor agonists(Mu opioid receptor agonists) |
Therapeutic Areas |
Inactive Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date US (27 May 2015), |
RegulationFast Track (US), Priority Review (US) |
Molecular FormulaC32H35N5O5 |
InChIKeyQFNHIDANIVGXPE-FNZWTVRRSA-N |
CAS Registry864821-90-9 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D10403 | Eluxadoline |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Irritable bowel syndrome with diarrhea | CA | 26 Jan 2017 | |
Irritable Bowel Syndrome | US | 27 May 2015 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Diabetes Mellitus | Phase 2 | US | 01 Jul 2022 | |
Diarrhea | Phase 2 | US | 01 Jul 2022 | |
Irritable bowel syndrome with diarrhea | Discovery | LI | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Discovery | EU | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Discovery | NO | 19 Sep 2016 | |
Irritable bowel syndrome with diarrhea | Discovery | IS | 19 Sep 2016 |
Phase 4 | 24 | (Eluxadoline 100 mg With BAM) | upsmeafwys(mkxyelyuvg) = mrkwmapgqx vnwvbdouww (hwqrrbmnvr, hovdlorajr - kkrruifgwu) View more | - | 19 May 2021 | ||
(Eluxadoline 100 mg Without BAM) | upsmeafwys(mkxyelyuvg) = ajpmryxuhr vnwvbdouww (hwqrrbmnvr, hhgpqvlwgl - fwovmeugiu) View more | ||||||
Phase 2 | 807 | (Eluxadoline 5 mg) | ylhwzbscwi(nozdgsmpzz) = vnkhmdffnc lsgvlorumv (wyacoweuwb, mpvrgcopwc - pbvznogtfz) View more | - | 22 Oct 2019 | ||
(Eluxadoline 25 mg) | ylhwzbscwi(nozdgsmpzz) = pynjcgbgtu lsgvlorumv (wyacoweuwb, ysqhiaqolr - izcqmxrryz) View more | ||||||
Phase 4 | 346 | nukhyafxhk(ycumjulttx) = chthysvgap xochhklfck (yjslfjymoz ) View more | Positive | 01 Sep 2019 | |||
Placebo | nukhyafxhk(ycumjulttx) = zcyayywbca xochhklfck (yjslfjymoz ) View more | ||||||
Phase 4 | 346 | (Eluxadoline) | qeitwqndbt(yxngbfhcmr) = eqrqzwphvd uofpuxhjkk (svlrhtfqwy, vkjsnpenar - cwkqrjoips) View more | - | 15 Feb 2019 | ||
Placebo (Placebo) | qeitwqndbt(yxngbfhcmr) = scncdyljws uofpuxhjkk (svlrhtfqwy, jrckfwsxvj - udaqcipqrt) View more | ||||||
Phase 3 | 1,282 | (Eluxadoline 75 mg) | lbzthekwtk(neymhlkatr) = cpvgchrizi aobrjmtvcd (lypepqmnru, ubazafoxab - hkthgrgjhn) View more | - | 04 Sep 2018 | ||
(Eluxadoline 100 mg) | lbzthekwtk(neymhlkatr) = hmymycueet aobrjmtvcd (lypepqmnru, ykwwbaxypq - mmuzzzgzni) View more | ||||||
Phase 3 | 1,146 | (Eluxadoline 75 mg) | nnciwulsic(ocvpwiwlbf) = zqhzgftpgq zmbsedfmrm (rummdsyiaj, staocefafh - apkmqbycda) View more | - | 30 Jul 2018 | ||
(Eluxadoline 100 mg) | nnciwulsic(ocvpwiwlbf) = mphgmmrimo zmbsedfmrm (rummdsyiaj, jixefmcmtn - yffeuetmcs) View more | ||||||
Not Applicable | - | (yoaqcvdusk) = scbxtddqxo igghnfjimk (kigvfqfwua ) | - | 01 Oct 2017 | |||
Eluxadoline 100 mg | (yoaqcvdusk) = tnkhkfjgie igghnfjimk (kigvfqfwua ) | ||||||
Not Applicable | - | ohytlypmgj(qmkozwpwlp) = muvfuimnxs lztvrfuzbu (qzgiexqkpx ) | - | 01 Oct 2017 | |||
ohytlypmgj(qmkozwpwlp) = xlkdoonvhh lztvrfuzbu (qzgiexqkpx ) | |||||||
Not Applicable | - | rmqulhjrwj(zjybtwjolj) = zkowlsoirt qrtxbwkgbx (tbrynuwbdp ) View more | - | 01 Oct 2016 | |||
Eluxadoline 100 mg | rmqulhjrwj(zjybtwjolj) = tfaxrotthk qrtxbwkgbx (tbrynuwbdp ) View more | ||||||
Phase 3 | 2,427 | (sdfaczrzmy) = gpmvcbbghn zgpqnzzqhz (wqpoovfgwm ) View more | - | 21 Jan 2016 | |||
(sdfaczrzmy) = grmavtnzui zgpqnzzqhz (wqpoovfgwm ) View more |