Delving into the Latest Updates on Ferrous Sulfate/Ascorbic Acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

iron sulfate (1:1), iron(2+) sulfate (anhydrous), iron(II) sulfate

Target-

Mechanism

Vitamin C supplements

Therapeutic Areas

Endocrinology and Metabolic DiseaseHemic and Lymphatic Diseases

Active Indication

Anemia, Iron-Deficiency

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC6H8O6

InChIKeyCIWBSHSKHKDKBQ-JLAZNSOCSA-N

CAS Registry50-81-7

View All Structures (2)

IntroductionThe increasing adoption of strict vegetarian diets during pregnancy has raised concerns about their effects on maternal and neonatal outcomes. This systematic review and meta-analysis aimed to assess the impact of strict vegetarian diets on key pregnancy outcomes, including neonatal birth weight, small-for-gestational-age (SGA) infants, gestational diabetes mellitus (GDM), hypertensive disorders, and gestational weight gain (GWG).MethodsA comprehensive literature search across multiple databases yielded eight studies from various countries, involving a total of 72,284 participants. Primary outcomes included neonatal birth weight, SGA, preterm birth, GDM, and maternal hypertensive disorders.ResultsThe meta-analysis found that strict vegetarian diets were significantly associated with an increased risk of delivering SGA infants, with a pooled odds ratio (OR) of 2.71 (95 % confidence interval [CI]: 1.24 to 5.95; p = 0.01). Additionally, infants born to strict vegetarian mothers had lower birth weights, with some studies reporting a mean difference of 240g compared to omnivores. For GDM, no significant differences were found between strict vegetarians and omnivores, with a pooled OR of 0.64 (95 % CI: 0.37 to 1.11; p = 0.11). While vegans showed lower gestational weight gain and reduced risk of excessive weight gain, there was considerable heterogeneity in results regarding hypertensive disorders and preterm birth.ConclusionsStrict vegetarian diets during pregnancy are associated with an increased risk of SGA infants and lower birth weights. To mitigate these risks, specific dietary guidelines emphasizing adequate intake of critical nutrients such as vitamin B12, iron, omega-3 fatty acids, and iodine should be developed. Supplementation and tailored dietary counseling, incorporating fortified foods and plant-based sources like legumes, nuts, seeds, and algae-derived omega-3, are essential to ensure maternal and neonatal health. Further research is necessary to refine these guidelines and explore their impact on diverse populations.

01 Mar 2025·Physiology & Behavior

Investigating how eating behavior shapes mental health: A cross-sectional study

Article

Author: Türk, Öykü Peren ; Dağdelen, Selçuk ; Buyuktuncer, Zehra ; Tosun, Özgür

This study aimed to examine the relationship between eating behavior, nutritional status and mental health. It is a cross-sectional study conducted on a sample of 360 healthy individuals aged 19-64 years. The General Health Questionnaire (GHQ-12) was used to evaluate mental health and the Three-Factor Eating Scale (TFEQ-R21) was used to assess eating behavior. The Healthy Eating Index-2015 (HEI-2015) score was calculated from participants' 24 h food recalls as an indicator of diet quality. The mean age of the participants was 26.0 ± 8.40 years, and 50.6 % were female. Multivariate logistic regression model was performed. A statistically significant relationship was found between the participants' GHQ-12 score and both their emotional eating and uncontrolled eating scores (p < 0.001 for each). It was determined that individuals who had high levels of emotional eating and uncontrolled eating behaviors, along with higher dietary protein and lipid intake, and lower intake of long-chain fatty acids, were at a higher risk of mental health deterioration, according to the established model (R2 = 0.214). Dietary energy and nutrient intakes such as niacin, vitamin B12, folic acid, phosphorus, iron, sodium and carotene, as well as diet quality and BMI were not associated with mental health according to the model in this study. Eating behavior is associated with mental well-being, and nutritional status may be one of the underlying factors contributing to this association.

01 Feb 2025·European Journal of Nutrition

Is underweight associated with poorer diet, nutrient status, bone and cardiometabolic health, and school performance in Danish 8-11-year-olds?

Article

Author: Strandberg-Larsen, Katrine ; Damsgaard, Camilla T ; Aurup, Anne V. ; Andersen, Rikke ; Aurup, Anne V ; Damsgaard, Camilla T. ; Lauritzen, Lotte ; Biltoft-Jensen, Anja

AbstractPurposeUnderweight, i.e. low body mass index for age and sex, may indicate undernutrition, but despite high prevalence, this aspect is largely overlooked in children in high-income countries. We explored if dietary intake, nutrient status, body composition, bone mineralization, cardiometabolic markers and school performance differed in schoolchildren with underweight compared to normal- and overweight.MethodsWe used cross-sectional data from 815 Danish 8-11-year-old children collected in 2011. Intake of foods, macronutrients and key micronutrients (vitamin D, vitamin B12, calcium, iron, zinc and selenium) was assessed by 7-day dietary records. Measurements included anthropometry, dual-energy X-ray absorptiometry and tests of attention and reading skills. Fasting blood samples were analyzed for biomarkers of iron, long-chain n-3 fatty acids and vitamin D status as well as blood lipids, insulin and growth markers.ResultsEighty-three (10.2%) children had underweight and were shown to have a lower intake of energy, red meat, protein and zinc and higher intake of added sugar than children with normal- and overweight. They also had higher fish intake relative to overweight, but blood biomarkers did not differ between groups. Children with underweight had lower fat percent and bone mineralization compared to peers with normalweight, but apart from lower insulin, they did not differ in overall cardiometabolic health or school performance.ConclusionAlthough we found some differences in diet, there were no considerable differences in nutrient status, cardiometabolic health or school performance between children with underweight and their normalweight peers. However, the lower bone mineralization is a concern and needs further investigation.

100 Deals associated with Ferrous Sulfate/Ascorbic Acid

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB13257

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anemia, Iron-Deficiency	CN	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EHA2022	Not Applicable	COVID-19	60	Sucrosomial® iron	niomxndzwg(vzvzlirxco) = swovmmmfeg rkjkpriqdt (cuoqmmbrwu ) View more	-	10 Jun 2022
				iron oral formulation (No iron support)	niomxndzwg(vzvzlirxco) = gryhoqmety rkjkpriqdt (cuoqmmbrwu ) View more
EHA2019	Not Applicable	-	36	Iron Sulphate	cwciayfvua(lgphhbkwne) = tknbhecxvb jrsmlphglw (wajpavxmxg )	-	16 May 2019
				Sucrosomial® Iron	cwciayfvua(lgphhbkwne) = hibhmjyebp jrsmlphglw (wajpavxmxg )
EHA2019	Not Applicable	Myelodysplastic Syndromes	45	Group A (sodium ferrigluconate)	mmizeznfrw(zlzvgkldcu) = nmivxxzsvx ubwpzsaowf (vycgoymfuv ) View more	-	16 May 2019
				Group B (sucrosomial iron)	mmizeznfrw(zlzvgkldcu) = kyanuznacx ubwpzsaowf (vycgoymfuv ) View more
ASN2018	Not Applicable	Hodgkin's Lymphoma MDA-LDL \| NTBI \| TSAT ... View more	-	Oral ferrous sulfate 105mg	hkqicpmlsr(rtpyjcehel) = xnylmoeppb tpsgnjjnod (jjgzwwhimm, 104 - 320) View more	Positive	23 Oct 2018
				Oral Iron Administration (OIA) (Healthy volunteers)	nornoykuwh(rshdkarspo) = wpubmuedip qkqersswvc (ejoewblbbi, 68 - 124)
EHA2015	Not Applicable	Myelodysplastic Syndromes	107	ERYTHROPOIETIN (No support)	(wfrysatwbl) = pcnjrckrxy eblgxvvgvd (aupgyvffgh ) View more	-	21 May 2015
				Epo support	(wfrysatwbl) = frujyrmzbt eblgxvvgvd (aupgyvffgh ) View more
DOPPS (ASN2012)	Not Applicable	TSAT \| ferritin \| hemoglobin	-	IV Iron Dose	(iudncqieil) = gtfnzxymqr zfgmrypgje (snsbgzjkxi ) View more	Negative	30 Oct 2012
				IV Iron (TSAT < 30%)	(iudncqieil) = ksblgygggl zfgmrypgje (snsbgzjkxi ) View more
ASN2010	Not Applicable	Chronic Kidney Diseases	112	IV Iron	xmidgwaxkc(nsinkspwpt) = After IVfe, there were significant ↑ ’s in %fe rpsepotqoq (wzlvywmche ) View more	Positive	16 Nov 2010