Last update 15 Jul 2024

Tegatrabetan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Tegavivint, APL-121, BC-2059
Target
Mechanism
TBL1X inhibitors(transducin beta like 1 X-linked inhibitors)
Inactive Indication
Originator Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC28H36N4O6S2
InChIKeyGAPRVZKWPDRAJA-FGYAAKKASA-N
CAS Registry1227637-23-1

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Hepatocellular CarcinomaPhase 2
US
13 Sep 2023
Advanced Hepatocellular CarcinomaPhase 2
CA
13 Sep 2023
Acute Myeloid LeukemiaPhase 2
US
10 Apr 2023
Diffuse large B-cell lymphoma recurrentPhase 1
US
06 Mar 2023
Indolent B-Cell Non-Hodgkin LymphomaPhase 1
US
06 Mar 2023
Recurrent High-Grade B-Cell Lymphoma with MYC and BCL2 or BCL6 RearrangementsPhase 1
US
06 Mar 2023
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 1
US
06 Mar 2023
Refractory High-Grade B-Cell LymphomaPhase 1
US
06 Mar 2023
EGFR-mutated non-small Cell Lung CancerPhase 1
US
18 Jan 2022
metastatic non-small cell lung cancerPhase 1
US
18 Jan 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
13
overall
ulcfzifvey(dawsgjsjjz) = at least possibly related to treatment included anemia (2) and lymphopenia (2). A single patient had a grade 3 QT prolongation requiring cessation of tegavivint after cycle 3. ackbiqywzo (spawqevvrl )
Positive
14 Apr 2023
Phase 1
17
efeahzechl(rfbdhwzehm) = kptknpllyk dzjimlygnl (lddsrvjfhg )
Positive
15 Jun 2022
Phase 1
24
anfzwsksxq(rlrnuwtjso) = gmbkfzpmbe bmigpeueup (kxotibkkbh )
Positive
02 Jun 2022
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Regulation

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