AbstractPerilipins are evolutionarily conserved from insects to mammals. Drosophila lipid storage droplet‐1 (LSD‐1) is a lipid storage droplet membrane surface‐binding protein family member and a counterpart to mammalian perilipin 1 and is known to play a role in lipolysis. However, the function of LSD‐1 during specific tissue development remains under investigation. This study demonstrated the role of LSD‐1 in salivary gland development. Knockdown of Lsd‐1 in the salivary gland was established using the GAL4/UAS system. The third‐instar larvae of knockdown flies had small salivary glands containing cells with smaller nuclei. The null mutant Drosophila also showed the same phenotype. The depletion of LSD‐1 expression induced a delay of endoreplication due to decreasing CycE expression and increasing DNA damage. Lsd‐1 genetically interacted with Myc in the third‐instar larvae. These results demonstrate that LSD‐1 is involved in cell cycle and cell death programs in the salivary gland, providing novel insight into the effects of LSD‐1 in regulating salivary gland development and the interaction between LSD‐1 and Myc.

02 Jul 2020·Bioscience, Biotechnology, and BiochemistryQ4 · ENGINEERING & TECHNOLOGY

Biosorption of sterols from tobacco waste extract using living and dead of newly isolated fungus Aspergillus fumigatus strain LSD-1

Q4 · ENGINEERING & TECHNOLOGY

Article

Author: Guo, Lele ; Yang, Yingyue ; Wang, Mingdao ; Zhao, Mingqin ; Zhang, Xiaoping ; Liu, Fang

AbstractSterols are verified to be able to produce polycyclic aromatic hydrocarbons during its pyrolysis. In this study, a kind of Aspergillus fumigatus (LSD-1) was isolated from cigar leaves, and the biosorption effects on the stigmasterol, β-sitosterol, campesterol, cholesterol, and ergosterol by using living and dead biomass of LSD-1 were investigated. The results showed that both living and dead biomass could efficiently remove these sterols in aqueous solution and tobacco waste extract (TWE). Interestingly, compared with the living biomass of LSD-1, the dead biomass of LSD-1 not only kept a high adsorption efficiency but also did not produce ergosterol. Overall, dead biomass of LSD-1 was a more suitable biosorbent to sterols in TWE. Furthermore, Brunner-Emmet-Teller (BET), Fourier transformed infrared spectrometer (FTIR) and scanning electron microscope (SEM) analysis were used to explore the biosorption process of living and dead biomass and their differences, suggesting that the biosorption of sterols was a physical process.

01 Nov 2018·Journal of Diabetes and its ComplicationsQ3 · MEDICINE

Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes

Q3 · MEDICINE

Review

Author: Lucchese, Roberta ; Nicoletti, Giovanni Francesco ; Benincasa, Giuditta ; Lanza, Michele ; Sorriento, Antonio ; Sommese, Linda ; Napoli, Claudio ; Schiano, Concetta ; Alfano, Roberto

BACKGROUNDEpigenetics modulated tissue-specific gene expression during the onset of type 1 and type 2 diabetes and their complications.METHODSWe searched the PubMed recent studies about the main epigenetic tags involved in type 1 and type 2 diabetes onset and their clinical complications. PubMed studies about the epigenetic tags involved in type 1 and 2 diabetes onset was searched.RESULTSThe epigenetic methylation maps of cord blood samples highlighted differences in the methylation status of CpG sites within the MHC genes between carriers of diabetes type 1 DR3-DQ2 and DR4-DQ8 risk haplotypes. β cell-derived unmethylated INS DNA showed the decline of β-cell mass preserving insulin secretion. Differentially methylated regions in pancreatic islets from type 2 diabetes covered PDX1, TCF7L2, and ADCY5 promoters during islet dysfunction. The recruitment of SET7 and SUV39H1 histone methyltransferases and LSD-1 lysine-specific demethylase-1 at NF-kβ-p65 promoter in vascular cells was involved in coronary heart disease. Neutrophil extracellular trap, activated by protein arginine deiminase-4, impaired wound healing from diabetic foot ulcers. MiR-199a-3p over-expression induced coagulative cascade, swelling and pain by a down-regulation of SERPIN-E2 in diabetic peripheral neuropathy. A DNA hypo-methylation and histone hyper-acetylation at MIOX promoter led an overexpression of ROS, fibronectin, HIF-1α, and NOX-4 associated with diabetic tubulopathy. A hypo-methylation of H3K4 at SOD2 promoter by LSD-1 increased ROS causing diabetic retinopathy.CONCLUSIONSEpigenetics played a relevant role in prevention, diagnosis, and treatment of diabetes.

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	SE	Beactica Therapeutics AB	07 Mar 2022

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