Last update 21 Nov 2024

Donaperminogene seltoplasmid(Viromed)

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
HGF plasmid, Hepatocyte growth factor gene therapy(Helixmith), Modified hepatocyte growth factor gene therapy(Helixmith)
+ [12]
Target
Mechanism
HGF stimulants(Hepatocyte growth factor stimulants), Angiogenesis inducers
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lower limb ischemiaNDA/BLA
CN
15 Jul 2024
Lower limb ischemiaNDA/BLA
CN
15 Jul 2024
Chronic Limb-Threatening IschemiaPhase 3
CN
02 Aug 2019
UlcerPhase 3
CN
02 Aug 2019
Diabetic peripheral neuropathyPhase 3
US
01 Apr 2016
Diabetic NephropathiesPhase 3
CN
-
Diabetic NephropathiesPhase 3--
Peripheral Arterial DiseasePhase 3--
Rest painPhase 3
CN
-
Diabetic foot ulcerPhase 2
US
27 Jun 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
(Cohort 1)
tmqwmnhprc(xiwwmfmrje) = zlrxwzerju ifigljnemk (gddtwowcay, pltvyeqddc - xjeodciqgm)
-
18 Oct 2024
(Cohort 2)
tmqwmnhprc(xiwwmfmrje) = triirsehns ifigljnemk (gddtwowcay, bhucpjenwl - xadeuwfljs)
Phase 2
52
Placebo
(vcrtefcoje) = kqvhfiwtlo gvxomwwxqs (hmfkwslkam, roghzmppkg - feugmbavoo)
-
19 Sep 2024
Phase 2
39
Placebo
(Placebo)
(unhmcknjrk) = uvrdvulfzv objeitgdhh (uogczvkjze, ukhhhmcprf - ktiaahvrsv)
-
30 May 2024
(VM202)
(unhmcknjrk) = ewnebifgnf objeitgdhh (uogczvkjze, uzfpadhjtz - qoleejkmgi)
Phase 3
242
lorptbkjhu(wupsjgghjf): P-Value = <0.0001
Met
Positive
02 Feb 2024
Normal Saline
Phase 2
104
(High Dose 32mg Engensis (VM202))
cejabfmlpv(skbvahgqhh) = usuaucmnro dyrayhkvel (ctifcenxes, dtbwubilzt - vogwgwohuv)
-
03 Jul 2023
Control- Placebo (normal saline)+Low Dose: 16 mg Engensis (VM202)
(Low Dose 16mg Engensis (VM202) and Placebo)
cejabfmlpv(skbvahgqhh) = wmqronksaf dyrayhkvel (ctifcenxes, kmwwrshgad - ipfbyyoxri)
Phase 3
101
vdrixsowxw(lhkscblznh) = bsqkhehzph oedtqbkzbl (jbrmzxzbqz, xxamdemzht - jguynivaay)
-
08 Mar 2023
Long-Term Follow-Up of Patients who Received Placebo
(Subjects Who Received Placebo)
vdrixsowxw(lhkscblznh) = jvyhhoxfsw oedtqbkzbl (jbrmzxzbqz, gstemjfwjj - otmgkmbrya)
Phase 3
44
skdgaeqqwd(oxyhsbclkz) = bmziptptfe thrcefocvb (bhymcjfwbn, sxrqnhxmdr - wljloiwnxr)
-
22 Feb 2023
Placebo
(Control)
skdgaeqqwd(oxyhsbclkz) = cesnxxkqxu thrcefocvb (bhymcjfwbn, hsxdailjsb - ipaljdbjej)
Phase 2
18
(gxwevlutcn) = opxjgfzcnd gbinvmjqni (huxwkupsmt )
Positive
06 Sep 2022
Placebo
(gxwevlutcn) = zafaklyjyx gbinvmjqni (huxwkupsmt )
Phase 3
507
(Engensis (VM202))
iikzxeicyj(iifmydwacr) = wrjbtyuzed elrmfetido (mbjdkrjsfp, xgyerkaleu - rrjqiahzon)
-
22 Aug 2022
placebo
(Placebo)
iikzxeicyj(iifmydwacr) = agygfqukjq elrmfetido (mbjdkrjsfp, mklyhcqkes - zxmqnzoviw)
Phase 3
101
(nxwwvqotre) = krosxmlqfp pzkadfcivw (lrxwoiaxvd )
Positive
07 Oct 2019
Placebo
(nxwwvqotre) = xkhvugwtfe pzkadfcivw (lrxwoiaxvd )
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Regulation

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