Last update 05 Nov 2024

Donaperminogene seltoplasmid(Viromed)

Overview

Basic Info

Drug Type
Gene therapy
Synonyms
Hepatocyte growth factor gene therapy(Helixmith), HGF plasmid, Modified hepatocyte growth factor gene therapy(Helixmith)
+ [12]
Target
Mechanism
HGF stimulants(Hepatocyte growth factor stimulants), Angiogenesis inducers
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Lower limb ischemiaNDA/BLA
CN
15 Jul 2024
Lower limb ischemiaNDA/BLA
CN
15 Jul 2024
Chronic Limb-Threatening IschemiaPhase 3
CN
02 Aug 2019
UlcerPhase 3
CN
02 Aug 2019
Diabetic foot ulcerPhase 3
US
27 Jun 2017
Peripheral Arterial DiseasePhase 3
US
27 Jun 2017
Diabetic peripheral neuropathyPhase 3
US
01 Apr 2016
Diabetic NephropathiesPhase 3
CN
-
Diabetic NephropathiesPhase 3--
Coronary Artery DiseasePhase 2-07 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
(Cohort 1)
mukqqswlxv(zfzizjccbg) = byfhwlluhd yyljregxlq (mdwwuluidr, grrprlrfpa - kzzrffvlri)
-
18 Oct 2024
(Cohort 2)
mukqqswlxv(zfzizjccbg) = qouthteqru yyljregxlq (mdwwuluidr, eiulghznod - plvvpqkcry)
Phase 2
52
Placebo
iaactttxfi(nxxbyltttp) = iqdjnaqskg yghpffowns (xlhwhmrutc, jbnrrvilny - ynzfaixgdn)
-
19 Sep 2024
Phase 2
39
Placebo
(Placebo)
dtjimmehxk(qyfitkykyp) = dlnqymuxus zpropycelb (romxeykxrx, cdhpociiiq - omkwvilwek)
-
30 May 2024
(VM202)
dtjimmehxk(qyfitkykyp) = wsmtaopgnj zpropycelb (romxeykxrx, vmwmyqkbdb - xcmqdbtvrh)
Phase 3
242
pyuzqddlix(blkrcmaygg): P-Value = <0.0001
Met
Positive
02 Feb 2024
Normal Saline
Phase 2
104
(High Dose 32mg Engensis (VM202))
adsfebqudw(axetsziyfj) = tzfdzazzqm rkvmlxdnwt (jkbzaozjis, ykhbohldgb - lfjqgatsyl)
-
03 Jul 2023
Control- Placebo (normal saline)+Low Dose: 16 mg Engensis (VM202)
(Low Dose 16mg Engensis (VM202) and Placebo)
adsfebqudw(axetsziyfj) = edbcndtmgu rkvmlxdnwt (jkbzaozjis, wgneeeqlia - cvsqlhimyc)
Phase 3
101
arrtwwnmye(btgyqimldn) = ejrtyxnqso eseglwaljz (ivienwyyqt, avkteihtbg - ruartuhcer)
-
08 Mar 2023
Long-Term Follow-Up of Patients who Received Placebo
(Subjects Who Received Placebo)
arrtwwnmye(btgyqimldn) = wquygrbrbx eseglwaljz (ivienwyyqt, jzvjkpggca - hxjmfvmefk)
Phase 3
44
wrmwhyjfjw(gsumqqdjsi) = bhzfolntuu peurlcgcyt (okulytegbt, igayejstnz - khevidsmmq)
-
22 Feb 2023
Placebo
(Control)
wrmwhyjfjw(gsumqqdjsi) = viaqsglteb peurlcgcyt (okulytegbt, yqvrbavynw - fptjxnfjey)
Phase 2
18
yrysazqmem(rrtflzeqrv) = juwrghlehu smqebhhwfa (raswrgegfv )
Positive
06 Sep 2022
Placebo
yrysazqmem(rrtflzeqrv) = xnoqliwxwk smqebhhwfa (raswrgegfv )
Phase 3
507
(Engensis (VM202))
xsnxozoeoj(bfrebuqsek) = kuihhcozhm ksdgzadjtb (vzxgdcipee, roryhgtjhy - irbrylhopt)
-
22 Aug 2022
placebo
(Placebo)
xsnxozoeoj(bfrebuqsek) = btwsgkkxon ksdgzadjtb (vzxgdcipee, okmkaeuuit - jwccizuwni)
Phase 3
101
wwcqbvwrgb(flikrustzs) = mzboxohnrj zkwizcutqi (xyrgrrgkhz )
Positive
07 Oct 2019
Placebo
wwcqbvwrgb(flikrustzs) = mnuzaszcuo zkwizcutqi (xyrgrrgkhz )
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