Last update 26 Jul 2025

Levobutylphthalide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Dl-3-butylphthalide, Dl-3-n-butylphthalide, L-butylphthalide
+ [4]
Action
inhibitors
Mechanism
KCNK inhibitors(Potassium two pore domain channel subfamily K inhibitors), KEAP1 inhibitors(Kelch-like ECH-associated protein 1 inhibitors), Nrf2 inhibitors(Nuclear factor erythroid 2-related factor 2 inhibitors)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic breast cancerPhase 2-30 Jun 2023
Metastatic breast cancerPhase 2-30 Jun 2023
Peripheral Nervous System DiseasesPhase 2-30 Jun 2023
Peripheral Nervous System DiseasesPhase 2-30 Jun 2023
Acute Ischemic StrokePhase 2
United States
28 Feb 2018
StrokeIND Application
China
17 Feb 2005
Acute myocardial infarctionPreclinical
China
01 Sep 2025
Alzheimer DiseasePreclinical
China
16 Jun 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Pubmed
ManualManual
Not Applicable
118
kidszcwbfv(cvinflnlcb): Difference (Mean) = 0.106 (95% CI, 0.018 - 0.195), P-Value = 0.003
Positive
22 Nov 2024
Placebo
Not Applicable
35
Combination therapy group (NBP 200mg three times daily plus donepezil 5mg or 10mg daily)
laexrfpahz(vumyokgviu): OR = 0.866 (95% CI, 0.082 - 9.179), P-Value = 0.905
Positive
01 Jul 2019
Phase 1/2
84
(Dl-3-n-butylphthalide)
kpztpkttvc(mthfzokonw) = uahmjselvd dlxtwexjjx (exvxswnmbx, 2.48)
-
18 May 2016
(Cerebrolysin)
kpztpkttvc(mthfzokonw) = aoatclsjrs dlxtwexjjx (exvxswnmbx, 5.81)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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