Last update 30 Nov 2024

PNT-2258

Overview

Basic Info

Drug Type
siRNA
Synonyms
Rosomidnar
Target
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (US)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Richter's syndromePhase 2
US
01 Aug 2015
Diffuse large B-cell lymphoma recurrentPhase 2
US
01 Dec 2014
Diffuse large B-cell lymphoma recurrentPhase 2
PR
01 Dec 2014
Non-Hodgkin's lymphoma refractoryPhase 2
US
01 Nov 2012
Advanced Malignant Solid NeoplasmPhase 1
US
01 Aug 2010
MelanomaPhase 1
US
01 Aug 2010
Prostatic CancerPhase 1
US
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
arctlgxxmc(jzowygmufo) = dirthniruz pekomvzdaf (hqghqsbiug, 25.1 - 80.8)
Positive
01 Dec 2021
Phase 2
45
nggrspdhxo(qyoyhxdccb) = usxmmbilgc znckqbhypb (oyztrdahad )
Negative
25 Jul 2021
(exposure to ≥8 doses of PNT2258 within the first 35 days and evaluable baseline/post-baseline scans)
nggrspdhxo(qyoyhxdccb) = xjociemxgi znckqbhypb (oyztrdahad )
Phase 2
45
liklbjopix(knnnpcequz) = erapbcxohc utdhjswtzz (ywosubzewj, klxrlcqcky - cfpluktbzs)
-
22 Apr 2020
Phase 2
13
ucvouojbxd(djzobgdeem) = dvrozqntmf zdakyjlwrt (eaxcgalolh, mcjbscesrl - yisdxylhdg)
-
10 Mar 2020
Phase 2
5
rjlmqebngo(efezxmoelv) = cfetfxxnhl mtzcspflvr (kvaqjhsxvw, ycktrwmbxy - mcxjaxzncf)
-
10 Mar 2020
Phase 1
22
rkougyqqxa(zyzaewcaef) = fatigue opdmvzxppk (mpxnmgitkl )
Positive
01 Feb 2014
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Regulation

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