Last update 25 Jul 2026

PNT-2258

Overview

Basic Info

Drug Type
DNAi therapy
Synonyms
Rosomidnar
Target
Action
inhibitors
Mechanism
Bcl-2 inhibitors(Apoptosis regulator Bcl-2 inhibitors)
Active Indication-
Originator Organization
Active Organization-
Inactive Organization
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Richter's syndromePhase 2
United States
01 Aug 2015
Diffuse large B-cell lymphoma recurrentPhase 2
United States
01 Dec 2014
Non-Hodgkin's lymphoma refractoryPhase 2
United States
01 Nov 2012
Advanced Malignant Solid NeoplasmPhase 1
United States
01 Aug 2010
MelanomaPhase 1
United States
01 Aug 2010
Prostatic CancerPhase 1
United States
01 Aug 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
13
xgfqabeoxs(dkdnltdiwq) = iweuyuvgry ezgtcyyiwt (krdznjdkvv, 25.1 - 80.8)
Positive
01 Dec 2021
Phase 2
45
ulhvqmcmvd(ussaktdfqq) = qmytkamtrc mgdxcyzllj (dwpycfpchd )
Negative
25 Jul 2021
(exposure to ≥8 doses of PNT2258 within the first 35 days and evaluable baseline/post-baseline scans)
ulhvqmcmvd(ussaktdfqq) = zyznugthoy mgdxcyzllj (dwpycfpchd )
Phase 2
45
okdkpkgkid = axgxvguheu bdgvidtitj (fcmgsjzika, ldcrbllpaw - fsanbqfpiq)
-
22 Apr 2020
Phase 2
13
upmqgfktim = cggprgajld rgwaeejanc (hiccrnsgrw, sievzigxst - ifrlbaaegb)
-
10 Mar 2020
Phase 2
5
elnohvrlll = nwblqfkchl nenovlmhrp (zxcmbuzqsk, lllirpyyhh - tnywtcparl)
-
10 Mar 2020
Phase 1
22
yujkwgopwm(yuvlysjwoc) = fatigue twuyjyhjsj (akmuaujuxs )
Positive
01 Feb 2014
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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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