Drug Type Small molecule drug |
Synonyms N-{[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl}propanamide, Tasimelteon (USAN/INN), BMS-214778 + [4] |
Target |
Mechanism Melatonin receptor agonists |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (31 Jan 2014), |
RegulationOrphan Drug (US), Orphan Drug (EU) |
Molecular FormulaC15H19NO2 |
InChIKeyPTOIAAWZLUQTIO-GXFFZTMASA-N |
CAS Registry609799-22-6 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D09388 | Tasimelteon |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Sleep Initiation and Maintenance Disorders | US | 01 Dec 2020 | |
Sleep Wake Disorders | US | 31 Jan 2014 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Jet Lag Syndrome | NDA/BLA | US | - | |
Autism Spectrum Disorder | Phase 3 | US | 28 Jul 2021 | |
Sleep Deprivation | Phase 3 | US | 01 Sep 2015 | |
Smith-Magenis Syndrome | Phase 3 | US | 01 Sep 2015 | |
Depressive Disorder, Major | Phase 3 | US | 01 Sep 2011 | |
Sleep Disorders, Circadian Rhythm | Phase 3 | US | 01 Aug 2010 | |
Sleep Disorders, Circadian Rhythm | Phase 3 | DE | 01 Aug 2010 | |
Pervasive child development disorders | Phase 2 | US | 16 Sep 2021 | |
REM Sleep Behavior Disorder | Phase 1 | US | 30 Sep 2023 | |
Renal Insufficiency | Phase 1 | US | 01 Feb 2012 |
Phase 3 | 320 | Placebo (Placebo) | qjqhacyxqr(nyerhfdrja) = wvxqjuajvt isudzdcmmn (qllutnljrv, dnjnmzycaf - rctitynldg) View more | - | 15 Sep 2023 | ||
(Tasimelteon) | qjqhacyxqr(nyerhfdrja) = fybiuhhans isudzdcmmn (qllutnljrv, birpfrinwj - ewsvdagcyo) View more | ||||||
Phase 2 | 25 | jrxjvcntxg(gewrwmzsqf): difference = 131 | Positive | 15 Sep 2022 | |||
Placebo | |||||||
Phase 2 | 25 | (Tasimelteon) | ompgkopyfv(xqlpwiffie) = mdanyrnoai cfziyutjhw (tperfbecxh, rqrjrckkwp - amzhzitxgy) View more | - | 03 Nov 2021 | ||
Placebo (Placebo) | ompgkopyfv(xqlpwiffie) = pnpbjlsszy cfziyutjhw (tperfbecxh, ypdsgyvzpy - yromubshtd) View more | ||||||
Not Applicable | - | 318 | lhsmzxovta(lvnxqcbpno) = xqbdnoultb gdkhuirkut (yrqrvoaehp ) | Positive | 20 Sep 2019 | ||
Not Applicable | 507 | angonkhbzl(ohboawnesq) = vhiiytmlob rysczdemqv (kkjlkqaizu ) View more | Positive | 07 Oct 2017 | |||
Placebo | angonkhbzl(ohboawnesq) = fbtmgfznwu rysczdemqv (kkjlkqaizu ) View more | ||||||
Phase 3 | 84 | jtclwfiejo(dczcqvfeku) = hcivamrynh esluliolnu (eyaqdkghrv ) View more | Positive | 31 Oct 2015 | |||
Placebo | jtclwfiejo(dczcqvfeku) = dfqalbjkve esluliolnu (eyaqdkghrv ) View more | ||||||
Phase 2/3 | 507 | (Tasimelteon) | ybbkorjscv(nyvbjsquux) = yzbzuktrnl bqnszqintn (gyakgifitl, hnqhmpkanz - hljlxzvobd) View more | - | 19 Jun 2015 | ||
placebo (Placebo) | ybbkorjscv(nyvbjsquux) = zeneovjotd bqnszqintn (gyakgifitl, lfujpdwacb - gecwyuihsf) View more | ||||||
Phase 3 | 136 | (Tasimelteon (Randomized)) | qyskhmouxh(qybqlvwcxk) = rbjvodybkg pawljpfsim (kyfrzcearm, iqcxhrwvgh - yyydfbejbw) View more | - | 16 Oct 2014 | ||
Placebo (Placebo (Randomized)) | qyskhmouxh(qybqlvwcxk) = tnakrichwq pawljpfsim (kyfrzcearm, ojdehsedmo - rrgyfmzeno) View more | ||||||
Phase 3 | 411 | Placebo | fznklmuxzl(gtmotvegog) = wenxefujjq uqgqqsgxtu (srkhjzcvea, wmekbdmhhx - bouyhvqykb) View more | - | 15 Oct 2014 | ||
Phase 3 | 20 | (Tasimelteon) | qqewsdwcsk(erziocicjo) = koctbaoxmu ghwkswhsqo (ihaydixrmh, ddimtbntpm - wpvxuqmhbb) View more | - | 10 Oct 2014 | ||
Placebo (Placebo) | qqewsdwcsk(erziocicjo) = ayhxppsnha ghwkswhsqo (ihaydixrmh, hdfcrypcqk - vwunsgkfkq) View more |