Marine sponges are a host of different symbiotic groups of bacteria playing crucial roles in the protection and survival of marine sponges. Marine symbiotic bacteria from sponges are promising sources of bioactive chemicals and are increasingly being investigated. Therefore, the present study was undertaken to analyze total compounds from active symbiotic bacterial strain from sponge, Pione vastifica. Potential bacterial strain EA276 previously isolated from P. vastifica and was identified as Spongiobacter sp. Among 57 isolates, only 42% exhibited antagonistic activity. Four major classes of bacteria were reported previously where γ-Proteobacteria, was the dominant class. From these active antagonistic bacterial isolates, a potential bacterial strain Spongiobacter sp. EA276 was selected, and total metabolites were identified using GC and LC-MS analyses. Using LC-MS analysis bioactive compounds Dichlorphenamide, Amifloxacin and Carbenicillin are identified in both positive and negative mode. Plant growth hormones, Indole-3-acetic acid and Methyl jasmonate were identified using GC-MS analysis from culture extract of strain Spongiobacter sp. EA276. Our results highlighted the significance of marine flora inhabiting sponges from the Red Sea as potential source of bioactive compounds and plant growth hormones of biological and agricultural significance.

01 Apr 2020·Saudi Journal of Biological Sciences

Antimicrobial activity of bacteria from marine sponge Suberea mollis and bioactive metabolites of Vibrio sp. EA348

Article

Author: Naseer, Muhammad Imran ; Yasir, Muhammad ; Azhar, Esam Ibraheem ; Bibi, Fehmida ; Al-Sofyani, Abdulmohsin

Discovery of potential bioactive metabolites from sponge-associated bacteria have gained attraction in recent years. The current study explores the potential of sponge (Suberea mollis) associated bacteria against bacterial and fungal pathogens. Sponge samples were collected from Red sea in Obhur region, Jeddah, Saudi Arabia. Of 29 isolated bacteria belong to four different classes i.e. Firmicutes (62%), γ-Proteobacteria (21%), α-Proteobacteria (10%) and Actinobacteria (7%). Among them nineteen (65%) bacterial strains showed antagonistic activity against oomycetes and only 3 (10%) bacterial strains were active against human pathogenic bacteria tested. Most bioactive genera include Bacillus (55%), Pseudovibrio (13%) and Ruegeria (10%). Enzyme production (protease, lipase, amylase, cellualse) was identified in 12 (41%) bacterial strains where potential strains belonging to γ-Proteobacteria and Firmicutes groups. Production of antimicrobial metabolites and hydrolysates in these bacteria suggest their potential role in sponge against pathogens. Further bioactive metabolites from selected strain of Vibrio sp. EA348 were identified using LC-MS and GC-MS analyses. We identified many active metabolites including antibiotics such as Amifloxacin and fosfomycin. Plant growth hormones including Indoleacetic acid and Gibberellin A3 and volatile organic compound such as methyl jasmonate were also detected in this strain. Our results highlighted the importance of marine bacteria inhabiting sponges as potential source of antimicrobial compounds and plant growth hormones of pharmaceutical and agricultural significance.

01 Dec 2019·Environmental Science and Pollution ResearchQ3 · ENVIRONMENTAL SCIENCE & ECOLOGY

Combined HQSAR method and molecular docking study on genotoxicity mechanism of quinolones with higher genotoxicity

Q3 · ENVIRONMENTAL SCIENCE & ECOLOGY

Article

Author: Zhao, Xiaohui ; Wang, Xiaolei ; Li, Yu

Using the hologram quantitative structure-activity relationship (HQSAR) method, a quantitative model of the structure-activity relationship between the genotoxicity of quinolones towards gram-negative bacteria and structure of quinolones is constructed. A series of novel quinolones are designed, and 4 environmentally friendly quinolone derivatives are finally selected, because of their enhanced genotoxicity towards gram-negative/positive bacteria, decreased bioconcentration and increased photodegradability and biodegradability. The mechanisms underlying the genotoxicity of quinolones and its derivatives are analysed based on amino acid residues and molecular interactions. Three hydrophilic amino acids [arginine (ARG), asparagine (ASN) and aspartic acid (ASP)] play important roles in the antibacterial effects of quinolones. The introduction of highly hydrophilic groups into the C-7 position of amifloxacin (AMI) not only improved the stability of the AMI derivative-topoisomerase IV-DNA complex but also improved the antibacterial activities of AMI derivatives.

100 Deals associated with Amifloxacin mesylate

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Indication	Highest Phase	Country/Location	Organization	Date
Gram-Negative Bacterial Infections	Phase 2	JP	Sanofi Winthrop LP	-
Gram-Negative Bacterial Infections	Phase 2	-	Astellas Pharma, Inc.	-
Gram-Negative Bacterial Infections	Phase 2	-	Sanofi	-
Gram-Negative Bacterial Infections	Phase 2	US	Sanofi Winthrop LP	-
Shock, Septic	Phase 2	-	Astellas Pharma, Inc.	-
Shock, Septic	Phase 2	-	Sanofi	-
Shock, Septic	Phase 2	US	Sanofi Winthrop LP	-
Urinary Tract Infections	Phase 2	US	Sanofi Winthrop LP	-
Urinary Tract Infections	Phase 2	-	Astellas Pharma, Inc.	-
Urinary Tract Infections	Phase 2	-	Sanofi	-

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