Onasemnogene abeparvovec

Like Zolgensma, Novartis' Itvisma is a one-time treatment that delivers a functional copy of the human SMN gene to treat SMA. Novartis has received an FDA approval for Itvisma, a new version of the company’s gene therapy Zolgensma, to treat older patients with spinal muscular atrophy (SMA).The approval comes more than six years after the FDA first cleared Zolgensma for SMA patients under 2 years old. Itvisma now covers all older patients with a confirmed mutation in the SMN1 gene.Both therapies work by delivering a functional copy of the human SMN gene via adeno-associated virus (AAV) vectors. While their active drug substances are identical, Itvisma is given directly to the central nervous system via an intrathecal injection in the spinal cord area, whereas Zolgensma is administered intravenously. Thanks to that formulation, Itvisma can be given to patients with larger weight in a more concentrated dose.Novartis is pricing Itvisma at a wholesale acquisition cost of $2.59 million, a company spokesperson told Fierce Pharma. At that price, the one-time therapy costs 35% to 46% less than existing chronically dosed treatments over the span of 10 years, according to the spokesperson.Patients’ out-of-pocket cost may vary, although Novartis expects broad coverage, the spokesperson added. The company is offering a patient support program in which eligible individuals may pay as little as $0.About 9,000 people in the U.S. live with SMA, and the majority of them are older children, teens and adults, Tracey Dawson, Ph.D., Novartis’ head of U.S neuroscience business, said in an interview with Fierce Pharma ahead of the approval.Given the broader patient population, Novartis has projected multibillion-dollar peak sales for Itvisma, also known as OAV101 IT. Since its initial approval in 2019, Zolgensma has treated more than 5,000 patients globally. Last year, the intravenous therapy brought in sales of $1.2 billion, making it the world’s best-selling gene therapy. Itvisma is geared toward patients who’re considering an option that may free them from the burden of chronic treatment, Dawson said. Novartis expects many of Itvisma’s recipients to be switching from existing therapies such as Biogen’s Spinraza and Roche’s Evrysdi, she said.Itvisma proved its worth in that population in the phase 3b Strength trial. Among 27 patients who discontinued treatment with either Spinraza or Evrysdi, their motor function, as measured by the Hammersmith Functional Motor Scale Expanded (HFMSE) score, showed stabilization over one year after receiving Itvisma. For the 66-point assessment, patients on Itvisma saw an increase in HFMSE least squares score of 1.05 by one year.The intrathecal gene therapy also works in treatment-naïve patients. In the Steer study, Itvisma showed a statistically significant 2.39-point improvement on the HFMSE, versus 0.51 points in patients who got a sham treatment.“While the numbers might not look huge, what it means from a clinical impact to a patient is that they’re able to continue to use their wheelchair controls, or they’re able to continue to walk,” Dawson said.Some of the seemingly tiny improvements, such as being able to keep grip strength, are meaningful to SMA patients, she said.To counter newer SMA options, Biogen has developed a higher-dose version of Spinraza. The new formulation just scored backing from the Committee for Medicinal Products for Human Use of the European Medicines Agency, setting up for a marketing authorization from the European Commission. Following a complete response letter in September related to certain technical information request, the FDA has accepted a resubmission from Biogen and has set a target decision date for high-dose Spinraza on April 3, 2026. Novartis is investing heavily in neuromuscular diseases lately. The Swiss pharma is shelling out about $12 billion to acquire Avidity Biosciences. The deal would give Novartis an RNA-based platform that produces antibody oligonucleotide conjugates, plus three late-stage muscular dystrophy programs.The deal follows another smaller acquisition a year ago of AAV gene therapy specialist Kate Therapeutics, which leverages in vivo expression of transgene RNA. 

Novartis has secured FDA approval for a new version of its one-time gene therapy for spinal muscular atrophy (SMA) that it says could benefit a much broader swathe of patients. The Swiss drugmaker said the agency greenlit Itvisma for SMA patients aged two years and older with a confirmed mutation in their SMN1 gene. Novartis told Endpoints News that Itvisma will carry a $2.59 million price tag to reflect its “transformative value.” Itvisma is “identical” to Novartis’ older SMA gene therapy Zolgensma, except for a different concentration and method of delivery, according to an FDA release . Zolgensma is approved for infants with SMA under the age of two with biallelic mutations in the SMN1 gene. Itvisma is injected directly into the fluid around the spinal cord, which means it can get to the motor neurons using a lower dose of the vector than for Zolgensma, and without needing adjustment for patients’ weight. Zolgensma is given intravenously at a weight-adjusted dose. Zolgensma pulled $301 million in the three months ended September. The treatment was approved in 2019 and has a US list price of about $2.1 million. Monday’s approval builds on Novartis’ legacy of “redefining SMA care with the first gene replacement therapy for this challenging disease,” US head Victor Bultó said in the release . Itvisma should be available in the US in December. There are around 9,000 people living with SMA in the US, according to Novartis. The disease is caused by lack of functional SMN protein. Zolgensma is used for some babies with a severe form of SMA who are at risk of death before the age of two without treatment. With the Itvisma approval, Novartis can reach other patients who have a mutation in their SMN1 gene but may have extra copies of the SMN2 gene. These patients produce slightly more functional SMN. Patients with more copies of the SMN2 gene tend to have less severe symptoms and better expectancy. Itvisma was approved based on data that showed it significantly improved motor function and stabilized motor abilities in a Phase 3 trial called STEER and an open-label study called STRENGTH. Additional reporting by Lei Lei Wu.