Drug Type Small molecule drug |
Synonyms (1S)-1,4-dideoxy-4-imino-(9-deazahypoxanthin-9-yl)-D-ribitol, 1,4-Dideoxy-4-aza-1-(S)-(9-deazahypoxanthin-9-yl)-D-ribitol, FDS + [10] |
Target |
Action inhibitors |
Mechanism PNP inhibitors(Purine nucleoside phosphorylase inhibitors), Immunosuppressants |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Drug Highest PhaseApproved |
First Approval Date Japan (31 Mar 2017), |
RegulationOrphan Drug (Japan) |
Molecular FormulaC11H15ClN4O4 |
InChIKeyWEIAMZKHBCLFOG-QPAIBFMUSA-N |
CAS Registry284490-13-7 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D04245 | Forodesine Hydrochloride |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Peripheral T-Cell Lymphoma | Japan | 31 Mar 2017 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Chronic Lymphocytic Leukemia | Phase 2 | United States | 01 Jun 2005 | |
CD19-positive B-cell acute lymphoblastic leukemia | Phase 2 | United States | 01 Sep 2004 | |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | Phase 2 | United States | 01 Sep 2004 | |
T-Cell Leukemia | Phase 2 | Georgia | 01 Mar 2004 | |
T-Cell Leukemia | Phase 2 | United States | 01 Mar 2004 | |
CD30-Positive recurrent or refractory Cutaneous T-Cell Lymphoma | Phase 2 | United States | 01 Feb 2003 | |
Cutaneous T-Cell Lymphoma | Phase 1 | United States | 01 Jul 2007 | |
Cutaneous T-Cell Lymphoma | Phase 1 | Finland | 01 Jul 2007 | |
Cutaneous T-Cell Lymphoma | Phase 1 | United Kingdom | 01 Jul 2007 | |
Recurrent T Lymphoblastic Lymphoma | Phase 1 | United States | 01 Jul 2006 |
Phase 2 | Peripheral T-Cell Lymphoma Second line | 48 | (syjruiujiv) = ekgvftlusd tluqummejw (dpunvpympa, 14 - 38) View more | Positive | 01 Jan 2019 | ||
Phase 1/2 | 44 | (tzqyacdobp) = rnwbpvxfau cwudyzursr (vcrhqwzsrm, 12.0 - 35.3) View more | Positive | 20 May 2016 | |||
Phase 2 | 144 | (pxtdwajnci) = mptkwpmans jhzdebmfvm (eiawvssbsa ) View more | - | 01 Sep 2014 | |||
Not Applicable | 64 | (rnggtarocp) = cfnulzgclb rsbqklrxss (kncxqfinnd ) View more | - | 20 May 2009 |