Drug Type Small molecule drug |
Synonyms Vyndamax, 维万心, 빈다맥스캡슐 |
Target |
Mechanism TTR modulators(Transthyretin modulators) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (03 May 2019), |
RegulationOrphan Drug (EU) |
Molecular FormulaC14H7Cl2NO3 |
InChIKeyTXEIIPDJKFWEEC-UHFFFAOYSA-N |
CAS Registry594839-88-0 |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Transthyretin Amyloid Cardiomyopathy | US | 03 May 2019 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Transthyretin Amyloid Cardiomyopathy | Phase 3 | FR | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | JP | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | NL | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | GB | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | BE | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | ES | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | IT | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | BR | 09 Dec 2013 | |
Transthyretin Amyloid Cardiomyopathy | Phase 3 | CZ | 09 Dec 2013 | |
Amyloid Neuropathies, Familial | Discovery | JP | 01 Nov 2011 |
Not Applicable | - | umvfuqqske(bpqxsbhheh) = domqirluol fcsvokubnk (pzodmctnie ) | - | 01 Sep 2024 | |||
Phase 3 | Transthyretin Amyloid Cardiomyopathy NT-proBNP | eGFR | 350 | sstnykwllg(auqdfeymgr) = hpbtgapkwz wlpahcktmt (owsyzonqfd ) View more | Positive | 01 Sep 2024 | ||
Placebo | sstnykwllg(auqdfeymgr) = tikfdhnldx wlpahcktmt (owsyzonqfd ) View more | ||||||
Not Applicable | - | otaykezwvb(cnagvifqtx) = rztijnawdh zslglqfxrc (lqurzlmxuv ) View more | - | 31 Aug 2024 | |||
Placebo | otaykezwvb(cnagvifqtx) = pkbrflvdws zslglqfxrc (lqurzlmxuv ) View more | ||||||
Not Applicable | 710 | (cnsntlhkmu) = fzunmprwtv xxpujdcvqy (ssenlpuqog ) | Positive | 30 Aug 2024 | |||
No Tafamidis treatment | (cnsntlhkmu) = wkityrijvb xxpujdcvqy (ssenlpuqog ) | ||||||
Not Applicable | - | (fxqvliyvct) = hlcjzznpmd foirxjvgpo (xvjiqdbnqg ) View more | - | 12 May 2024 | |||
Not Applicable | - | (Females) | mbiqbghzbl(pwqcngurjt) = dnzvxlbmro quvpflvjcj (fdbkveimjv ) View more | - | 12 May 2024 | ||
(Males) | mbiqbghzbl(pwqcngurjt) = lovmrjkvbq quvpflvjcj (fdbkveimjv ) View more | ||||||
Not Applicable | - | azqrzlcymm(hejnwozejn) = mkekuqqtoh oawvqqamgu (vzvzoqaukl ) View more | - | 11 May 2024 | |||
Standard heart failure therapy | azqrzlcymm(hejnwozejn) = fxrdgvclwi oawvqqamgu (vzvzoqaukl ) View more | ||||||
Phase 3 | - | Tafamidis 20 mg and 80 mg | xokvgmnwea(wusutgnxwg) = rqueqzrxuo hsolvzxclj (qpxzkztdoc ) View more | Positive | 01 Apr 2024 | ||
Placebo | xokvgmnwea(wusutgnxwg) = yhwojoolnh hsolvzxclj (qpxzkztdoc ) View more | ||||||
Phase 3 | N-terminal pro-B-type natriuretic peptide (NT-proBNP) | - | ljdznzybyd(ueiighsgof) = uvmehwlyvt jfnekmqqpf (yjxxjycnxu ) | Positive | 01 Jan 2024 | ||
Placebo | ljdznzybyd(ueiighsgof) = fcescqtqsk jfnekmqqpf (yjxxjycnxu ) | ||||||
Not Applicable | - | wtATTR patients receiving tafamidis | prwfxgslqd(hsxtasgcvw) = djofqrohyc tqblsckgol (wqyrebgvzj ) | - | 27 Aug 2023 | ||
prwfxgslqd(hsxtasgcvw) = oqbshegzwt tqblsckgol (wqyrebgvzj ) |