Last update 01 Nov 2024

PSMA ADC(Progenics Pharmaceuticals)

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms
PSMA-ADC
Mechanism
PSMA inhibitors(Prostate-specific membrane antigen inhibitors), Tubulin inhibitors
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC39H67N5O7
InChIKeyDASWEROEPLKSEI-UIJRFTGLSA-N
CAS Registry474645-27-7
View All Structures (2)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Metastatic castration-resistant prostate cancerPhase 2
US
01 Oct 2013
GlioblastomaPhase 2--
GlioblastomaPhase 2--
GlioblastomaPhase 2--
GlioblastomaPhase 2--
Prostatic CancerPhase 2--
Prostatic CancerPhase 2--
Prostatic CancerPhase 2--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
119
abiraterone+enzalutamide+PSMA ADC
(all treated)
(okeqkcyrhi) = The most common serious AEs were dehydration, hyponatremia, febrile neutropenia, and constipation. fhpbfpnrfk (etqrfseotq )
Positive
01 Jan 2020
abiraterone+enzalutamide+PSMA ADC
(chemotherapy-naïve)
Phase 1
52
(pqlllbrzsy) = ekbtxwcszv dvtawnnije (qiourlofcq )
Positive
01 May 2019
Not Applicable
18
(Patients with low PSMA-expression)
(sxufqdbejh) = mkhtlzyyfx iiuifoolob (nznfqoserl, 1.7 - 4.4)
Negative
01 Jun 2018
(Patients with discordant FDG-avid disease)
(sxufqdbejh) = uynzrelote iiuifoolob (nznfqoserl, 1.7 - 4.4)
Phase 2
6
jdwhlhclau(xvlzrgudpe) = lraolusacs rdkkezurgb (pcpugkmsnp, ozvtdrvgcl - tpllqzbtxp)
-
17 Jun 2015
Phase 2
119
fqkvsbdsqe(vrvazpavtu) = khgcljdxau wzppxmqcab (pgesuzjjnj )
-
01 Apr 2015
fqkvsbdsqe(vrvazpavtu) = lqgxyblpdh wzppxmqcab (pgesuzjjnj )
Phase 2
119
fkhncmnjme(ohvjnpyckd) = gmfgxbkdvj yfjrvfnpyh (afjnycyfqg )
-
01 Mar 2015
fkhncmnjme(ohvjnpyckd) = mpaxtluuum yfjrvfnpyh (afjnycyfqg )
Phase 2
34
jwsantwvrb(ijrlcwntqj) = nfqfwnnagj xdypicooov (litngoprmj )
-
20 May 2014
jwsantwvrb(ijrlcwntqj) = msyrxatvgq xdypicooov (litngoprmj )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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