Last update 01 Dec 2024

DP-4088

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DP 4088, DPOC-4088
Target
thrombin
Mechanism
thrombin inhibitors(Factor IIa inhibitors)
Therapeutic Areas
Cardiovascular DiseasesHemic and Lymphatic Diseases
Active Indication-
Inactive Indication
Atrial FibrillationBlood Coagulation DisordersVenous Thrombosis
Originator Organization
Merck & Co., Inc.Merck & Co., Inc.
Active Organization-
Inactive Organization
Diakron Pharmaceuticals, Inc.Merck Sharp & Dohme Corp.Merck Sharp & Dohme Corp.Orchid Website Design Ltd.Orchid Website Design Ltd.
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Structure

Molecular FormulaC19H16ClF3N6O2
InChIKeyAATHXZYXWMKUFC-UHFFFAOYSA-N
CAS Registry312904-62-4

Related

2
Clinical Trials associated with DP-4088
NCT01647620 / TerminatedPhase 1
A Randomized, Double-blind, Placebo-controlled, Stepwise Study of the Pharmacokinetics (PK), Pharmacodynamics (PD), PK/PD Characteristics and Safety of Multiple Once-daily Oral Dosing of DPOC-4088 in Healthy Young Male Subjects
NCT01347203 / CompletedPhase 1
A Randomized, Open-label, 4-period Crossover Study to Evaluate the Pharmacokinetics (PK), Pharmacodynamics (PD) and the PK/PD Relationship of DPOC-4088 After Single Oral Dosing of 100 and 200 mg in 2 Prolonged Release Formulations (16 and 20 hr) in 12 Healthy Young Male Subjects
100 Clinical Results associated with DP-4088
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100 Translational Medicine associated with DP-4088
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100 Patents (Medical) associated with DP-4088
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100 Deals associated with DP-4088
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Atrial FibrillationPhase 1
BE
Diakron Pharmaceuticals, Inc.
01 Feb 2012
Venous ThrombosisPhase 1
BE
Diakron Pharmaceuticals, Inc.
01 Apr 2011
Blood Coagulation DisordersPhase 1
BE
Diakron Pharmaceuticals, Inc.
-
Blood Coagulation DisordersPhase 1-
Orchid Website Design Ltd.Orchid Website Design Ltd.
-
Blood Coagulation DisordersPhase 1-
Merck Sharp & Dohme Corp.Merck Sharp & Dohme Corp.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Approval

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Regulation

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