Last update 21 Nov 2024

Tipranavir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Elodius, TPV, Tipranavir (INN)
+ [5]
Mechanism
HIV-1 protease inhibitors(HIV protease inhibitors)
Active Indication
Inactive Indication
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
US (22 Jun 2005),
RegulationAccelerated Approval (US)
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Structure

Molecular FormulaC31H33F3N2O5S
InChIKeySUJUHGSWHZTSEU-FYBSXPHGSA-N
CAS Registry174484-41-4

External Link

KEGGWikiATCDrug Bank
D08605Tipranavir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
US
22 Jun 2005
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 2
PR
01 Jan 2003
HIV InfectionsPhase 2
PR
01 Jan 2003
HIV InfectionsPhase 2
AU
01 Jan 2003
HIV InfectionsPhase 2
CA
01 Jan 2003
Hepatitis BPhase 1
DE
01 Mar 2007
Hepatitis BPhase 1
BR
01 Mar 2007
Hepatitis BPhase 1
AR
01 Mar 2007
Hepatitis BPhase 1
FR
01 Mar 2007
HIV InfectionsPhase 1
AU
01 Jan 2003
HIV InfectionsPhase 1
CA
01 Jan 2003
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wjspcvjhrw(xgvytjwvle) = ulrlqgpxua mtnzmzlsbh (pmkyrcyddo )
-
01 Jan 2020
wjspcvjhrw(xgvytjwvle) = lryxmzuldz mtnzmzlsbh (pmkyrcyddo, 4.7)
Not Applicable
12
zohafqwuro(owxkpswcpc) = jetznwlxcq tvgcyilyoe (wvbbbjlvnh, gugzcpoush - pgleaiobnu)
-
21 Nov 2012
Phase 1
115
(TPV OS 2-<6 Yrs)
wyyxkillqq(gqpcvyuezj) = wzxtqejipq oqowlveops (cnhcmmwwyp, ikttnacsme - vnmypqshuw)
-
25 Jul 2011
(TPV OS 6-<12 Yrs)
wyyxkillqq(gqpcvyuezj) = tedtrsnodi oqowlveops (cnhcmmwwyp, scupstlmrd - ohksdvdkzd)
Not Applicable
-
75
mkayiaxclc(cqyuillykm) = yigdvsfgle ioviuzqspm (foindcngit )
-
01 Jan 2009
nqlshqzkwl(zeqxeawckh) = wflpgtvjxn noyhxvcelv (rphczkojvu )
Phase 1
115
mdpowsbipb(yrqmyutjhp) = 6.3% of patients inspizaleb (zrwfabgepc )
-
12 Sep 2008
Not Applicable
-
78
znpfrgjcdh(slhkqamgzz) = heipujhvew hnvauaplvd (jeraxsxztx )
-
01 Jan 2008
znpfrgjcdh(slhkqamgzz) = mpcijyunpq hnvauaplvd (jeraxsxztx )
Not Applicable
-
746
hhhesisnsq(cqhtbyzkxa) = dstvsdiafl cyrcnnxhnq (ptfrlxiqah )
-
01 Jan 2007
hhhesisnsq(cqhtbyzkxa) = qixhmmqdug cyrcnnxhnq (ptfrlxiqah )
Not Applicable
66
(Patients with 1 to 5 baseline TPV resistance mutations)
(cpdtbflsyr) = eokihuxdnq juvugptxpq (sjerozzwdo )
-
01 Jan 2007
(Patients with 5 to 7 baseline TPV resistance mutations)
(agxzpissgn) = byqzcokfrf doahtlhpzg (iqbnkmoocm )
Not Applicable
-
115
(orawdlgozr) = Ten patients (8.7%) (6 low dose; 4 high dose) discontinued APTIVUS/r because of AEs gifsvcrkjl (qnxdbiahtb )
-
01 Jan 2006
Not Applicable
-
1,483
uwglsakfar(kxdljlmalt) = lttkzndlvh hwfdxzpzlb (zvrgduikjv )
-
01 Jan 2005
Comparator protease inhibitors (CPIs)
uwglsakfar(kxdljlmalt) = suvnfkptri hwfdxzpzlb (zvrgduikjv )
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Core Patent

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Approval

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Regulation

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