Drug Type Small molecule drug |
Synonyms Denufosol, Denufosol tetrasodium (USAN), INS 37217 ophthalmic + [3] |
Target |
Mechanism P2Y2 receptor agonists(Purinergic receptor P2Y2 agonists) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization |
Active Organization- |
Inactive Organization |
Drug Highest PhaseDiscontinuedPhase 3 |
First Approval Date- |
Regulation- |
Molecular FormulaC18H27N5Na4O21P4 |
InChIKeyUJXLEAFWHDAVEO-WMUGRWSXSA-N |
CAS Registry318250-11-2 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
D03685 | Denufosol Tetrasodium | - |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Pulmonary Cystic Fibrosis | Phase 3 | - | 01 Jul 2006 | |
Cystic Fibrosis | Phase 3 | US | - | |
Cystic Fibrosis | Phase 3 | AU | - | |
Cystic Fibrosis | Phase 3 | CA | - | |
Cystic Fibrosis | Phase 3 | NZ | - | |
Dry Eye Syndromes | Phase 3 | US | - | - |
Rhinitis, Allergic, Perennial | Phase 3 | US | - | - |
Uveitis | Phase 2 | - | 01 Sep 2005 | |
Macular Edema | Phase 2 | - | 01 Aug 2005 | |
Retinal Detachment | Phase 2 | US | 01 Jun 2004 |
Phase 3 | 466 | anzicnwyzc(jvxkibritc) = xdyssgasbo ehlgxhqvkz (xsqpqdaaiq ) View more | Negative | 01 Dec 2012 | |||
Placebo | anzicnwyzc(jvxkibritc) = waqxtfiliz ehlgxhqvkz (xsqpqdaaiq ) View more | ||||||
Phase 3 | 352 | wwtsohuhke(nqzwfmrzsn) = ipbwrzhoed dsxrgykoym (bwbyiaplai ) | Positive | 01 Mar 2011 | |||
Placebo | wwtsohuhke(nqzwfmrzsn) = awucwttxcz dsxrgykoym (bwbyiaplai ) | ||||||
Not Applicable | - | - | INS37217 (100µM) | kdjdjpzcbb(fgqaznhfxx) = mmkhdxwjao nzntteisij (lvqiqmirxu ) | - | 01 Dec 2002 |