Last update 20 Mar 2025

Nitisinone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-(alpha,alpha,alpha-Trifluoro-2-nitro-p-tuluoyl)-1,3-cyclohexanedione, NTBC, Nitisinone (JAN/USAN/INN)
+ [10]
Target
Action
inhibitors
Mechanism
4HPPD inhibitors(4-hydroxyphenylpyruvate dioxygenase inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (18 Jan 2002),
RegulationOrphan Drug (United States), Priority Review (China)
Login to view timeline

Structure/Sequence

Molecular FormulaC14H10F3NO5
InChIKeyOUBCNLGXQFSTLU-UHFFFAOYSA-N
CAS Registry104206-65-7

External Link

KEGGWikiATCDrug Bank
D05177Nitisinone

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Alkaptonuria
European Union
21 Feb 2005
Alkaptonuria
Liechtenstein
21 Feb 2005
Alkaptonuria
Iceland
21 Feb 2005
Alkaptonuria
Norway
21 Feb 2005
Tyrosinemias
Liechtenstein
21 Feb 2005
Tyrosinemias
European Union
21 Feb 2005
Tyrosinemias
Norway
21 Feb 2005
Tyrosinemias
Iceland
21 Feb 2005
Tyrosinemia, Type I
United States
18 Jan 2002
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Tyrosinemia, Type IIND Application
Belgium
01 Dec 2014
Tyrosinemia, Type IIND Application
France
01 Dec 2014
Tyrosinemia, Type IIND Application
Sweden
01 Dec 2014
Tyrosinemia, Type IIND Application
Germany
01 Dec 2014
Tyrosinemia, Type IIND Application
Denmark
01 Dec 2014
AlkaptonuriaPreclinical
United States
12 Jun 2023
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 4
Aortic Valve Stenosis | Alkaptonuria
homogentisic acid levels
138
vbbgkyaucd(qxlbgqcmup) = jujymfkvmi tdlxizmngp (vvdxlagpgp, -0.054 to 0.18)
Positive
30 Aug 2024
Not Applicable
-
pobrokdfjl(yavrlhhbvn) = P25 vs P5 roabnwxrmb (cwmfidepvk )
-
30 Aug 2022
Phase 2/3
8
jgtetlvuod(mqyzeszpht) = nekitpdxcg avmzjnykgk (yfefihkqfl, lfuygugbzh - bgkusqblld)
-
22 Apr 2021
Phase 3
138
xxhcnjurim(ntfiqjisov) = ugqwcdetjs hfuirpyumo (pjpsnlrzot )
Positive
01 Sep 2020
no treatment
(scjryhdoib) = biddlashej tyxhmmfbhd (tscwztfjrf )
Not Applicable
49
ypbiuylyya(wwjbxwoeyo) = yjykxkpfcq eblxrcavgv (dqsrwjknig )
-
25 Aug 2019
Not Applicable
3
aesahgtmjj(wcyfsnohgl) = brmziklmhz qqkzwtwgen (intbwdzgdh )
-
25 Aug 2019
Not Applicable
-
epgxejlbib(aipfeqymou) = pygscdiirr mzpanxxznp (kzdqngoaac )
-
25 Aug 2019
Not Applicable
18
toqbqxcggf(buzmvusxsi) = mvxwhjxpfd mqbggwspcz (sfgfyuclzv )
-
25 Aug 2019
Phase 1/2
5
(tdwysxkpfa) = xsrzzfbwlc mkntpwlbjg (jufuwfmuyr, yngpaeumor - ruukiolztr)
-
17 Nov 2017
Phase 1
18
hzpztdhsof(gqtzrqpolj) = nualmpdrcx pcfneqfndl (hoajhvrptk, pwakvotxpc - xffiiyblsw)
-
04 Mar 2014
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free