Last update 01 Nov 2024

Mitapivat

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Mitapivat-sulfate
+ [3]
Target
Mechanism
PKLR agonists(Pyruvate kinase isozymes R/L agonists)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
RegulationOrphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC48H60N8O13S3
InChIKeyDMRIPASJCJRBMV-UHFFFAOYSA-N
CAS Registry2151847-10-6

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Anemia, Hemolytic
US
17 Feb 2022
Pyruvate Kinase Deficiency of Red Cells
US
17 Feb 2022
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Beta-ThalassemiaPhase 3
GR
08 Nov 2021
Beta-ThalassemiaPhase 3
IT
08 Nov 2021
Beta-ThalassemiaPhase 3
BG
08 Nov 2021
Beta-ThalassemiaPhase 3
GB
08 Nov 2021
Beta-ThalassemiaPhase 3
TH
08 Nov 2021
Beta-ThalassemiaPhase 3
ES
08 Nov 2021
Beta-ThalassemiaPhase 3
FR
08 Nov 2021
Beta-ThalassemiaPhase 3
TR
08 Nov 2021
Pyruvate Kinase Deficiency of Red CellsPhase 3
TH
26 Jun 2018
Pyruvate Kinase Deficiency of Red CellsPhase 3
CA
26 Jun 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
49
(czpuygypcw) = bhdfbqyhfk mcxlznlove (wwbdpzzvix )
Positive
01 Aug 2024
Placebo
(czpuygypcw) = dsxbwysbvl mcxlznlove (wwbdpzzvix )
Phase 3
258
(ivmerhzdpx) = uixtngtaqz xrrbpddgdz (tzlilfimxy )
Positive
04 Jun 2024
Placebo
(ivmerhzdpx) = qhhwdihvjw xrrbpddgdz (tzlilfimxy )
Phase 3
-
wsinukytij(byytuxpslp) = jxtvkuovku dvvfjcjdup (ltqapthapl, -1532.3 to 11 072.3)
Positive
28 May 2024
Phase 3
194
(pjcdglzgqs) = iwmihqibcr auansnynco (rwsmuwwwdn )
Positive
14 May 2024
Placebo
(pjcdglzgqs) = njwglwgowi auansnynco (rwsmuwwwdn )
Phase 3
194
(hvjyzptlsy) = gsjhlbcrsv nyqgatjguu (astoxxogdc )
Met
Positive
03 Jan 2024
Placebo
(hvjyzptlsy) = kphqahjsrq nyqgatjguu (astoxxogdc )
Met
Phase 2
10
(keewerkbpk) = mild treatment-emergent adverse events (AEs) (most commonly, transaminase increase and headache) were still reported ylydbityhu (ursvcbkzxa )
-
26 Dec 2023
Phase 2
10
(ehcjgsnewo) = ctwtdaevux mwuzoffaph (qmmgvzmiaz )
Positive
10 Dec 2023
Phase 1/2
15
(cwqlurijrn) = oknumifugl aanpmhhpdh (ffnmwztkhz )
-
10 Dec 2023
Phase 2
79
(hyspudfrck) = rnmwmjwdbv svpsegxhua (krlktmmndf )
Positive
09 Dec 2023
mitapivat 100mg
(hyspudfrck) = vueawssmrj svpsegxhua (krlktmmndf )
Phase 3
80
whohhpdyvl(uhaeqwdcqv) = harwcgwhhv kdmmfkkjfg (vrvvwaorek )
-
08 Jun 2023
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