The objective of this clinical trial is to assess the effectiveness of acetic acid in patients suffering from chronic cutaneous ulcers with biofilm. The primary question it seeks to address is whether acetic acid (as a 2% topical solution) is superior to the current standard treatment for chronic cutaneous ulcers with biofilm at our center (Prontosan®).
Participants will be randomly assigned to receive either the acetic acid solution treatment or the standard current treatment.

Start Date01 Mar 2025

Sponsor / Collaborator-

NCT06525870

/ Enrolling by invitationPhase 2IIT

Efficacy of Topical 85%Trichloroacetic Acid in the Treatment of Low-grade Squamous Intraepithelial Lesion (LSIL) After Low-grade Abnormality of Screening Test: a Randomized Controlled Trial

To determine the efficacy and HPV clearance of an application of 85% TCA compared to placebo in the treatment of LSIL. This is a randomized, single-blind, placebo-controlled study in 44 women aged 18-65 years with histologic-proved HPV/CIN1. The study will test whether 85% TCA application will be effective treatment in LSIL. The clinical study hypothesis is that TCA application at cervical lesion and transformation zone will achieve histologic complete remission of LSIL in significantly more patients than placebo therapy. Patients will be randomized to placebo (3% acetic acid) or 85%TCA topical application at cervical lesion and transformation zone. After 3 months, cytology, colposcopy, histology, and HPV testing will be performed. The primary endpoint is treatment efficacy defined as complete histologic remission at 3 months after treatment. The secondary endpoint is HPV clearance 3 months after treatment. The protocol for the project is approved by an Institutional Review Board (IRB). Project is totally supported by a grant from Rajavithi Hospital. There is no external funding.

Start Date01 Aug 2024

Sponsor / Collaborator

Rajavithi Hospital

100 Clinical Results associated with Acetic Acid, Glacial

100 Translational Medicine associated with Acetic Acid, Glacial

100 Patents (Medical) associated with Acetic Acid, Glacial

225,283

Literatures (Medical) associated with Acetic Acid, Glacial

31 Dec 2025·Bioengineered

Fractionation of waste-derived volatile fatty acids by multi-stage adsorption using activated charcoal and Diaion HP-20 resin

Article

Author: Taherzadeh, Mohammad J. ; Wainaina, Steven ; Basereh, Negar ; Mahboubi, Amir

Substituting waste-derived Volatile Fatty Acids (VFAs) with their conventionally applied fossil-derived counterparts in a spectrum of industrial applications necessitates its proper fractionation into individual acids. This study explored a multi-stage batch adsorption approach for fractionating acidogenic fermentation VFAs effluents from food waste (FW) and chicken manure (CKM) using Diaion HP-20 and activated charcoal. Initial screening at different washing conditions and pH (3.5 and 6.5) revealed the unwashed granular-activated charcoal (GAC-Unwashed) and milli-Q water-washed Diaion (DI-MQ Washed) as the most promising candidates for VFA fractionation of a synthetic VFA mixture at 4 gL^-1. At pH 3.5 (__-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__<pKa), GAC-Unwashed adsorbed 2-6 carbon atom VFAs completely, while DI-MQ Washed exhibited minimal adsorption of acetic acid (AA) (8%), favoring caproic (CA) and valeric acids (VA) (__-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__>97%). While at pH 6.5 __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__(>pKa), GAC-Unwashed selectively targeted VA (79%) and CA (100%). Fractionating VFAs from FW and CKM were conducted in a two-stage adsorption process with optimal results being achieved using GAC-Unwashed at FW initial pH (5.3) and DI-MQ Washed at pH below CKM __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__pKa (3.5), respectively. The first adsorption stage primarily adsorbed higher molecular weight (MW) VFAs (FW:99.1% CA, CKM:72.9% butyric acid (BA)) with a minor quantity of lower ones (FW:56.5% BA, CKM:29.3% propionic acid (PA)), leaving AA intact. Subsequent stages aimed to isolate AA by adsorbing the remaining low MW VFA (FW:58.9% BA, CKM:27.8% PA, 70% BA) other than AA, indicating effluent fractionation while preserving and purifying AA. Applied selective multi-stage adsorption approach offers a promising method to broaden waste-derived VFA applications.

31 Dec 2025·CyTA-Journal of Food

Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications

Author: Benali, Mohammed ; Gharibi, Elkhadir ; Mothana, Ramzi A. ; Ed-darraz, Fatima-Zahrae ; Bouyanzer, Abdelhamid ; Farihi, Ayoub ; Hawwal, Mohammed F. ; Hbika, Asmae

Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavor, has been used in a variety of culinary applications.This study investigates its metabolites through phytochem. methods.The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content.The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE.The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content.Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the Et acetate extract (42.4%).Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, Et acetate, and ethanol extracts, resp.ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.

31 Dec 2025·Energy Sources Part A-Recovery Utilization and Environmental Effects

Simultaneous improvement in qualities of bio-oil and syngas from catalytic pyrolysis of rice husk by demineralization

Author: Wang, Zhongwen ; Xiong, Yuanquan

This study aims to investigate the influences of different demineralization pretreatment processes on the properties of liquid and gas products from catalytic pyrolysis via activated carbon catalyst.To achieve this goal, deionized water, hydrochloric acid, and acetic acid were used to remove ash.The results indicated that leaching could remove a large amount of alkali and alk. earth metals (AAEMs).Besides, the experiments of different leaching solutions on catalytic fast pyrolysis of rice husks were conducted.It can be found that compared with direct pyrolysis, the catalytic pyrolysis produced more gas products, in which CO increased by 6.49%, while the bio-oil was concentrated in phenols (more than 90%).After demineralization, the content of CO in gas products further increased by 8.04%, while the relative content of phenol in bio-oil enhanced by 14.79% as well.Catalysis can enrich phenol in bio-oil, and leaching can enhance this enrichment.Meanwhile, demineralization can further improve the quality of syngas.The sample after demineralization by hydrochloric acid performed best on catalytic fast pyrolysis, where CO accounts for 57.68% volume of gaseous product and phenol accounted for 68.21% of bio-oil.

News (Medical) associated with Acetic Acid, Glacial

28 Aug 2024

·www.prnewswire.com

The Chemical Peel Market is projected to grow by USD 814.4 million from 2024 to 2028, driven by rising demand for aesthetic treatments and technological advancements, AI-powered report- Technavio

NEW YORK, Aug. 28, 2024 /PRNewswire/ -- Report on how AI is driving market transformation- The global chemical peel market size is estimated to grow by USD 814.4 millionn from 2024-2028, according to Technavio. The market is estimated to grow at a CAGR of 7.19% during the forecast period. Increasing demand for aesthetic procedures and technological advancement is driving market growth, with a trend towards increasing awareness about anti-aging measures. However, high cost of chemical peel products poses a challenge. Key market players include AbbVie Inc., AMOREPACIFIC Group Inc., Bausch Health Companies Inc., BeautyPharmaCo, Candela Corp., Caudalie International SE, Galderma SA, Hale Cosmeceuticals Inc, Image International Manufacturing LLC, Johnson and Johnson Services Inc., LOreal SA, MedPeel, Merz Pharma GmbH and Co KGaA, NEFTIS LABORATORIOS SL, Pierre Fabre SA, ProDerma Light, Radius Healthcare Pvt. Ltd., Renee Rouleau Inc., Topix Pharmaceuticals Inc., and Unilever PLC. Continue Reading Technavio has announced its latest market research report titled Global chemical peel market 2024-2028 Get a detailed analysis on regions, market segments, customer landscape, and companies - Click for the snapshot of this report Key Market Trends Fueling Growth The chemical peel market is experiencing significant growth due to the increasing awareness and demand for anti-aging procedures. In 2021 and 2022, there has been a rise in the number of cosmetic procedures performed in countries like the US, Brazil, Mexico, Germany, and Spain. This trend is driven by the advantages of chemical peels, including age spot reduction, sun damage removal, skin lightening, smoothening, and improved collagen growth. Vendors are actively promoting these benefits through various channels, such as websites, conferences, and magazine advertisements. Moreover, the increasing per capita income and economic development in emerging economies, particularly India and China, have led to a surge in online research and comparisons of various procedures. As a result, the chemical peel market is poised for continued growth during the forecast period. The Chemical Peel Market is witnessing significant growth due to the increasing demand for non-surgical skincare solutions. Trichloroacetic acid and Jessner's Solution are popular peeling agents used in chemical resurfacing for improving skin texture, reducing hyperpigmentation, acne scars, fine lines, and wrinkle reduction. These treatments are effective for sun damage, melasma treatment, and acne treatment. Medical aesthetics and cosmeceutical treatments using chemical formulations offer clinical benefits for various skin conditions. Glytone, Alpha hydroxy acid (AHA), sugar cane, sugar beets, lactic peel, milk, and Alpha-hydroxy acids (AHAs) are common peeling agents. Medium peels target the epidermis and dermis layers for enhanced skin health and beauty. The chemical peel procedure is a dermatologic treatment for skin health improvement and aesthetic enhancement. Discover a Comprehensive 360° Market Analysis: Understand the Impact of AI. For detailed information- Request Sample! Market Challenges The chemical peel market is currently facing a growth challenge due to the high cost of treatments, which is limiting its adoption, particularly in developing countries. The average price for a chemical peel ranges from USD600 to USD900, with significant variations depending on the type of peel. Light peels cost as low as USD150 but require multiple sessions for optimal results, while medium and deep peels can cost up to USD6,000. These high costs include fees for the chemical peel procedure, anesthesia, and operating room. The monopolistic approach of vendors, such as Allergan plc, in the market further contributes to the lack of competitive pricing. Allergan, a leading player in medical aesthetics, has acquired most of the market share, targeting high-income and upper-middle-class consumers. As a result, the inability of middle and lower-middle-class individuals to afford these costly procedures is hindering the growth of the global chemical peel market. The Chemical Peel market is thriving in the Skincare and Aesthetics industries, providing solutions for common concerns such as Acne, Pigmentation, and Wrinkle issues. Glytone's Peeling Solution, which contains Alpha Hydroxy Acids (AHAs) derived from Sugar Cane and Sugar Beets, is a popular choice for exfoliating the Epidermis. Medium Peels, using stronger Chemical Agents like TCA, reach deeper into the Dermis to address Acne spots, Dark Circles, and signs of Fatigue. Dermatology and Aesthetic Medicine professionals use these Dermatological Procedures for Skin Renewal, often combining different Chemical Compounds like Glycolic Acid, Lactic Acid, and Salicylic Acid for optimal results. The Beauty Industry continues to innovate with new Peeling Solutions, offering professional Chemical Exfoliation treatments for Facial Rejuvenation. For more insights on driver and challenges - Download a Sample Report Segment Overview This chemical peel market report extensively covers market segmentation by End-user 1.1 Hospital and recreation centers 1.2 Dermatology clinics Type 2.1 Light peel 2.2 Medium peel 2.3 Deep peel Geography 3.1 North America 3.2 Europe 3.3 APAC 3.4 South America 3.5 Middle East and Africa 1.1 Hospital and recreation centers- The Chemical Peel Market is experiencing steady growth due to increasing consumer awareness and demand for skin rejuvenation treatments. Businesses are offering various types of chemical peels to cater to diverse skin concerns, such as acne scars, aging, and sun damage. Market leaders are focusing on research and development to introduce innovative peel solutions and expand their customer base. Overall, the market is expected to continue its expansion in the coming years.For more information on market segmentation with geographical analysis including forecast (2024-2028) and historic data (2018 - 2022) - Download a Sample Report Research Analysis The Chemical Peel market encompasses a range of skincare treatments used in aesthetics to address various skin concerns, including acne, pigmentation, and wrinkle issues. These peels work by applying a chemical solution to the skin, causing it to exfoliate and peel off, revealing smoother, fresher skin. The solutions typically contain Alpha-hydroxy acids (AHAs) derived from fruits like glycolic acid from sugar cane and lactic peels from milk. Deeper peels may involve Phenol or Trichloroacetic acid, reaching the dermis for more significant results. Acne spots, dark circles, and signs of fatigue can also be targeted. Genetics and collagen production play a role in skin health, making chemical peels a popular choice for those seeking to improve their complexion in dermatology practices. Market Research Overview The Chemical Peel market encompasses a range of skincare treatments that utilize chemical solutions to improve the appearance of the skin. These peels are commonly used for various aesthetic concerns such as acne, pigmentation, and wrinkle issues. The solutions typically contain Alpha Hydroxy Acids (AHAs) derived from fruits like sugar cane and sugar beets, or Beta Hydroxy Acids (BHAs) like Salicylic Acid. The depth of the peel can vary from light to medium, affecting the epidermis or dermis layers. Chemical Peels are used to address acne spots, dark circles, fatigue, and signs of aging such as fine lines and wrinkles. The causes of these conditions can stem from genetics, sun damage, or lifestyle factors. The treatments promote collagen production, leading to skin renewal and texture improvement. Chemical Peels are considered a dermatological procedure and are also offered in aesthetic medicine clinics and the beauty industry. They provide a form of chemical exfoliation that goes beyond traditional cleansing methods. The solutions work by dissolving the bonds holding dead skin cells together, revealing smoother, healthier skin. Popular chemical peel formulations include Glytone, Jessner's Solution, TCA Peel, and various combinations of AHAs and BHAs. These treatments are administered as facial treatments in professional settings and are an essential part of medical aesthetics and cosmeceutical offerings. Chemical Peels contribute to skin health and beauty enhancement, addressing various skin conditions and concerns. They are an effective means of reducing hyperpigmentation, acne scars, sun damage, and melasma. The cosmetic procedure is a popular choice for individuals seeking wrinkle reduction and skin rejuvenation. Table of Contents: 1 Executive Summary 2 Market Landscape 3 Market Sizing 4 Historic Market Size 5 Five Forces Analysis 6 Market Segmentation End-user Hospital And Recreation Centers Dermatology Clinics Type Light Peel Medium Peel Deep Peel Geography North America Europe APAC South America Middle East And Africa 7 Customer Landscape 8 Geographic Landscape 9 Drivers, Challenges, and Trends 10 Company Landscape 11 Company Analysis 12 Appendix About Technavio Technavio is a leading global technology research and advisory company. Their research and analysis focuses on emerging market trends and provides actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios. Contacts Technavio Research Jesse Maida Media & Marketing Executive US: +1 844 364 1100 UK: +44 203 893 3200 Email: [email protected] Website: SOURCE Technavio

30 Jul 2024

·www.drugs.com

FDA Warns Against Purchasing or Using Chemical Peel Skin Products Without Professional Supervision

Audience: Consumer July 30, 2024 -- FDA is warning consumers not to purchase or use certain chemical peel skin products without appropriate professional supervision due to risk of serious skin injuries. The agency has not approved any chemical peel products, and consumers should only consider using chemical peel products under the supervision of a dermatologist or licensed and trained practitioner. Many of these chemical peel products are sold in beauty product stores and online and marketed for purposes such as acne, discoloration, wrinkles, and collagen production. They contain ingredients such as trichloroacetic acid (TCA), glycolic acid, salicylic acid and lactic acid in varying concentrations that are too high to be used safely at home without supervision by a dermatologist or other licensed and trained practitioner. Using products that contain high concentrations of these acids may lead to serious injury from chemical burns. The concentration, number of applications, and length of time a chemical peel product is left on the skin all influence how deeply it can penetrate skin layers and potentially lead to chemical burns. These products remove layers of skin to varying depths and may cause severe chemical burns, pain, swelling, infection, skin color changes, and disfiguring scars. These injuries may even require emergency care or specialty care from a dermatologist or surgeon. FDA has issued warning letters to the following companies for selling these products: FDA encourages health care professionals and consumers to report adverse events or quality problems with these or any medications to FDA’s MedWatch Adverse Event Reporting program: Source: FDA Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

14 Mar 2024

·www.prnewswire.com

New Tuberculosis Test Could Improve TB Care Globally by Increasing Access to Testing in Low- and Middle-Income Countries

Findings Published in ADLM's Clinical Chemistry Journal WASHINGTON, March 14, 2024 /PRNewswire/ -- A new tuberculosis (TB) test disclosed in the Association for Diagnostics & Laboratory Medicine's (formerly AACC's) Clinical Chemistry journal would allow testing for TB treatment monitoring to occur outside of a biosafety level 3 (BSL-3) laboratory. This could help reduce worldwide mortality from TB by enabling low- and middle-income countries that lack BSL-3 facilities to treat TB more efficiently. View the full study here: TB is the second leading infectious killer worldwide after COVID-19, and monitoring how the infection responds to treatment over time is a critical step in reducing mortality. However, because TB is highly infectious, patient samples can currently only be tested in BSL-3 laboratories, which contain resource-intensive features like directional air flow and incinerators that minimize the risk of contamination. This is a major hurdle to combatting TB globally, because approximately 80% of TB cases occur in low- and middle-income countries, many of which lack a BSL-3 laboratory. A team of researchers designed this test — called rapid enumeration and diagnostic for tuberculosis (READ-TB) — specifically to address lack of access to labs that meet BSL-3 requirements. This novel test determines how patients are responding to TB treatment. With READ-TB, sputum — thick mucus coughed up from the lungs — is treated with acetic acid, a chemical that kills bacteria but leaves bacterial RNA intact. A laboratory professional can then safely feed the RNA into a machine that measures RNA concentration, which is an indicator for how much Mycobacterium tuberculosis a patient is carrying and how the infection is responding to treatment. Compared to guanidium salts, the class of chemicals currently considered the gold standard for preserving RNA, acetic acid was more effective at killing sputum bacteria, doing so in just 30 minutes, which eliminates the need for a BSL-3 laboratory. Acetic acid was also just as effective as guanidium salts in preserving bacterial RNA. Notably, the researchers found that RNA was preserved in acetic acid for 14 days when kept at 25°C, and for at least 1 year when kept at –20°C. This is an important advantage for laboratories that lack –70°C freezers, which require a much greater amount of energy. Additionally, guanidium salts are toxic, while the concentration of acetic acid used for READ-TB is much safer to work with. Clinical trials for anti-TB drugs also stand to benefit from READ-TB. By providing a safe and efficient way to measure the concentration of TB RNA, it could enable researchers to compare the antibacterial strength and properties of drugs or combinations of drugs against one another. "We wanted to improve the assay for integration into diagnostic microbiology laboratories, for use in clinical trials, and to make it tenable in low- and middle-income countries, e.g., where no BSL-3 laboratory exists," the authors of the study write, referring to their earlier test. "READ-TB allows measurement of the molecular bacterial load to now be adopted by routine clinical microbiology laboratories for measuring M. tuberculosis bacterial load in sputum." About the Association for Diagnostics & Laboratory Medicine (ADLM) Dedicated to achieving better health through laboratory medicine, ADLM (formerly AACC) brings together more than 70,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of progressing laboratory science. Since 1948, ADLM has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit . Clinical Chemistry (clinchem.org) is the leading international journal of laboratory medicine, featuring nearly 400 peer-reviewed studies every year that help patients get accurate diagnoses and essential care. This vital research is advancing areas of healthcare ranging from genetic testing and drug monitoring to pediatrics and appropriate test utilization. CONTACT: Christine DeLong ADLM Senior Manager, Communications & PR (p) 202.835.8722 [email protected] Molly Polen ADLM Senior Director, Communications & PR (p) 202.420.7612 (c) 703.598.0472 [email protected] SOURCE Association for Diagnostics & Laboratory Medicine (ADLM)

Clinical Study

100 Deals associated with Acetic Acid, Glacial

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KEGG	Wiki	ATC	Drug Bank
D00010	Acetic Acid, Glacial	S02AA10 G01AD02	DB03166

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Indication	Highest Phase	Country/Location	Organization	Date
Contraception	Phase 2	China	Shanghai New Asiatic Pharmaceutical Minhang Co. Ltd.	03 Jun 2024
Contraception	Phase 2	China	Shanghai Institute of Biomedical Technology	03 Jun 2024

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EADV2023	Not Applicable	Alopecia Areata	40	Trichloroacetic Acid 35%	yrisselctj(ngaefmpnqm) = ymzkpeordh soqfwwspzz (ivzhbijdvn )	Positive	11 Oct 2023
TRICIN (ESGO2022)	Phase 2	Cervical Intraepithelial Neoplasia HPV 16 \| other high risk types	102	85% TCA	vlavvcyrht(mulggtnmbi) = rkvfjkeeqk yrrmhdzqop (jbobkjdzef, 66.0 - 83.5) View more	Positive	20 Oct 2022
EADV2022	Not Applicable	Cicatrix	30	Trichloroacetic acid	teghiudamp(peluedrewa) = bcdvqdcvkr htmvazrpet (ktudafpenh )	-	07 Sep 2022
TECAIN (IAS2021)	Not Applicable	Anal intraepithelial neoplasia	155	topical trichloroacetic acid (Electrocautery)	dastlgcagq(xlrvxkkrvq) = qeoxoigmtg hmmfbzukju (wplpyvpvtk )	-	01 Jan 2021
TECAIN (IAS2021)	Not Applicable	Anal intraepithelial neoplasia	155	Topical trichloroacetic acid	dastlgcagq(xlrvxkkrvq) = iycbxhlhbi hmmfbzukju (wplpyvpvtk )	-	01 Jan 2021
NCT02614703 (CTgov)	Phase 2/3	Barrett Esophagus	60	Chromoendoscopy using Acetic Acid 2.5% (Chromoendoscopy Using Acetic Acid 2.5%)	slquwtpdoo = thzltscojd utuuvewqrc (hymyyturld, sxzcwkjhyh - qvkikghifd) View more	-	26 Aug 2019
NCT02614703 (CTgov)	Phase 2/3	Barrett Esophagus	60	Standard random esophageal biopsies (Standard Random Esophageal Biopsies)	slquwtpdoo = ildvcofgtw utuuvewqrc (hymyyturld, druvtnmfcf - gtxybjwvab) View more	-	26 Aug 2019
ISN WCN2019	Not Applicable	Peritoneal Diseases	-	Acetic acid (2%)	epqzdarpqs(jyysfgtrzc) = ddileegtoj tovxttnllt (ptgenqbqto, 44.4)	-	01 Jul 2019
ISN WCN2019	Not Applicable	Peritoneal Diseases	-	Mupirocin	epqzdarpqs(jyysfgtrzc) = wpvabmmhxd tovxttnllt (ptgenqbqto, 37.1)	-	01 Jul 2019

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