GQ-1001

BRIDGEWATER, NJ, USA I April 18, 2023 I Pyramid Biosciences, Inc., a privately-held, clinical-stage biotechnology company focused on developing transformative medicines for patients with cancer, and its partner GeneQuantum Healthcare (Suzhou) Co. Ltd, a privately-held biotechnology company based in China, announced data at the American Association for Cancer Research (AACR) Annual Meeting 2023 highlighting the preclinical efficacy and safety profile of GQ1010, a potential best-in-class antibody drug conjugate (ADC) targeting trophoblast cell surface antigen 2 (TROP2), across several in vitro and in vivo models. The poster presentation highlights several preclinical studies which showcase the differentiating attributes of GQ1010. Specifically, in a mouse syngeneic MC38 colon cancer model, the combination of GQ1010 plus anti-PD-1 therapy showed compelling synergistic tumor growth inhibition, which was superior to DS-1062 plus anti-PD-1. In this study, the GQ1010 combination reported 5 of 6 animals achieved a complete response, compared to zero of 6 animals with the DS-1062 combination. In addition, GQ1010 showed more potent in vitro cytotoxicity and a superior bystander effect versus DS-1062, and increased in vivo tumor growth inhibition with GQ1010 monotherapy compared head-to-head with either DS-1062 or TRODELVY® across multiple cancer models. Safety findings with GQ1010 in a non-human primate (NHP) study indicated a differentiated profile and highest non-severe toxic dose (HNSTD) of greater than 30 mg/kg, which may translate to a wider therapeutic window in human studies relative to more advanced TROP2 ADCs in development. Plasma stability studies showed 98% retention of drug-to-antibody ratio (DAR) for GQ1010, attributable to its unique, irreversible cleavable linker chemistry. "These preclinical findings are driven by GQ1010's unique ADC design, which utilizes site-specific enzymatic conjugation technology and a novel linker-payload which confer potent cytotoxicity and better stability in the plasma," said Qin Gang, Ph.D., CEO of GeneQuantum Healthcare. "The preclinical differentiation seen with GQ1010 provides further validation of the capabilities of the GeneQuantum platform to produce best-in-class bioconjugates, as was also observed in a Phase 1a study of the HER2-directed ADC, GQ1001." "TROP2 is a highly validated target in oncology, and TROP2-directed therapies are an important potential treatment option for a large number of cancers," remarked Brian Lestini, MD PhD, CEO of Pyramid Biosciences. "However, despite the TROP2 agents currently approved or in development, there remains significant unmet need for therapies that improve efficacy while reducing the potential for serious toxicities and optimizing therapeutic index and combinability. Preclinical data demonstrates the potential for GQ1010's unique ADC chemistry to provide a superior, best-in-class clinical profile and improve patient outcomes. Based on this preclinical data, we are excited to be moving GQ1010 into clinical development." The AACR annual meeting poster presentation details are as follows: Title: Preclinical characterization of GQ1010, a next generation Trop2 ADC with the best-in-class potential against diverse Trop2 positive solid tumors First Author: Yajun Sun Session: PO.ET02.06 - Antibody Drug Conjugates Abstract #: 1549 About TROP2 TROP2 is a cell surface glycoprotein that is highly expressed in a variety of tumors including breast, lung, pancreatic, ovarian, and prostate cancer, and plays a role in tumor cell proliferation. Currently TRODELVY® (Gilead) is the only approved TROP2 ADC, with indications in triple-negative breast cancer, hormone-receptor positive breast cancer, and urothelial cancer. Clinical data have also been previously reported for TROP2 ADCs in development by Daiichi-Sankyo and Merck & Co. About Pyramid Biosciences, Inc. Founded in 2015, Pyramid Biosciences, Inc. is a clinical stage biotechnology company dedicated to developing transformative medicines for patients with cancer. Pyramid focuses on programs that target clinically validated mechanisms and with potential best-in-class properties that can address areas of high unmet need in cancer. Pyramid is currently conducting a global Phase 1/2 clinical trial of its lead oncology program PBI-200, a highly CNS penetrant next-generation NTRK inhibitor, in patients with NTRK-fusion driven cancers including primary and metastatic brain tumors. For more information, please visit www.pyramidbio.com . Pyramid Biosciences Media Inquiries: McDougall Communications on behalf of Pyramid Biosciences Laura DiCaprio This email address is being protected from spambots. You need JavaScript enabled to view it. // or +1-585-773-8005 Pyramid Biosciences Investor Inquiries: Biren Amin, Pyramid Biosciences, CFO, and Chief Strategy Officer This email address is being protected from spambots. You need JavaScript enabled to view it. // SOURCE: Pyramid Biosciences

BRIDGEWATER, NJ, USA I April 13, 2023 I Pyramid Biosciences, Inc. , a privately-held, clinical-stage biotechnology company focused on developing transformative medicines for patients with cancer, today announced that it has entered into an exclusive license agreement with GeneQuantum Healthcare (Suzhou) Co. Ltd, a privately-held biotechnology company based in China, to develop and commercialize GQ1010, a potential best-in-class antibody drug conjugate (ADC) targeting TROP2, worldwide except for Greater China (mainland China, Hong Kong, Macau, and Taiwan). GQ1010 has shown a highly differentiated preclinical profile, and is anticipated to enter a first-in-human trial within the next 12 months. "We are thrilled to be partnering with GeneQuantum in bringing this exciting asset, GQ1010, into the clinic," said Brian Lestini, M.D., Ph.D., Chief Executive Officer of Pyramid Biosciences. "By leveraging the unique features of the GeneQuantum bioconjugation platform and Pyramid's deep expertise in oncology drug development, this partnership significantly expands our growing oncology portfolio. This highly differentiated program has the potential to address substantial limitations of current ADCs and unmet needs for patients with TROP2-expressing tumors, a clinically validated target in oncology." "GeneQuantum was founded with the goal of addressing critical unmet needs in global healthcare through the development of innovative technologies. GQ1010 highlights its best-in-class potential through GeneQuantum's cutting-edge technology in the development of differentiated bioconjugate drugs such as GQ1001, an anti-HER2 ADC, which has demonstrated a differentiated profile in Phase 1 data. We believe this agreement between GeneQuantum and Pyramid Biosciences represents the ideal partnership to rapidly advance the worldwide development of GQ1010, and to help patients overcome their cancer," said Qin Gang, Ph.D., Chief Executive Officer of GeneQuantum. "Our collaboration with Pyramid for global development of the GQ1010 program brings together the best of GeneQuantum's proprietary technology and Pyramid's extensive capabilities and track record of success in delivering transformative medicines to patients with cancer." GQ1010 utilizes a unique site-specific conjugation technology and incorporates a novel linker-payload which may lead to improved stability, safety and potency of the ADC. Preclinical data suggests GQ1010 has a broader therapeutic margin compared to more advanced TROP2 ADCs, that may translate to an improved efficacy and safety profile for GQ1010. TROP2 is a cell surface glycoprotein that is highly expressed in a variety of tumors including breast, lung, pancreatic, ovarian, and prostate cancer, and plays a role in tumor cell proliferation. Under the terms of the agreement, Pyramid Biosciences will develop and commercialize GQ1010 in exchange for an upfront payment of $20 million and up to an additional $1 billion of milestone payments. GeneQuantum would also be eligible to receive tiered royalties ranging from mid-single digit to low double digits on net sales. About Pyramid Biosciences, Inc. Founded in 2015, Pyramid Biosciences, Inc. is a New Jersey-based, clinical stage, biotechnology company dedicated to developing transformative medicines for patients with cancer. Pyramid focuses on programs that target clinically validated mechanisms and with potential best-in-class properties that can address areas of high unmet need in cancer. Pyramid's lead oncology program PBI-200, a highly CNS penetrant next-generation NTRK inhibitor is currently in a global Phase 1/2 clinical trial in patients with NTRK-fusion driven cancers, including primary and metastatic brain tumors. For more information, please visit www.pyramidbio.com . SOURCE: Pyramid Biosciences