Delving into the Latest Updates on Domoic acid with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

DOM

Target

GRIK

Action

agonists

Mechanism

Kainate receptor agonists

Therapeutic Areas

Nervous System Diseases

Active Indication

Epilepsy

Inactive Indication-

Originator Organization

University of Prince Edward Island

Active Organization

University of Prince Edward Island

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

The goal of this platform clinical trial is to test how well novel treatment combinations work in participants with lung cancer. Substudy-01 will compare the different novel combinations versus standard of care in participants with metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC) who have not been treated before. Substudy-02 will compare the different novel combination versus standard of care in participants with cancer that has progressed after receiving previous treatment for metastatic NSCLC. Substudy-03 will compare the different novel combinations versus standard of care in participants with resectable stage II-III NSCLC.
The primary objectives of this study are:
Substudy-01 and Substudy-02: To evaluate the objective response rate (ORR) assessed per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1).
Substudy-03: To evaluate the efficacy of treatment combinations based on complete pathological response (pCR) rate.

Start Date16 Mar 2023

Sponsor / Collaborator

Gilead Sciences, Inc.

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100 Clinical Results associated with Domoic acid

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100 Translational Medicine associated with Domoic acid

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100 Patents (Medical) associated with Domoic acid

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1,216

Literatures (Medical) associated with Domoic acid

01 Jul 2025·Marine Pollution Bulletin

Low contamination and rapid depuration of domoic acid in the variegated scallop, Mimachlamys varia

Article

Author: Hégaret, Hélène ; Lassudrie, Malwenn ; Flye-Sainte-Marie, Jonathan ; Jean, Fred ; Terre-Terrillon, Aourégan ; Fabioux, Caroline ; Le Moan, Eline ; Derrien, Amélie

Harmful algal blooms (HABs) are natural proliferations of microalgal species, able to produce toxic compounds, such as domoic acid (DA), a neurotoxin responsible for the Amnesic Shellfish Poisoning (ASP) which can be lethal for mammals. Pectinid species are of high economic value and are particularly vulnerable to these events. As filter-feeders, they can accumulate DA and transfer it through the food web. However, DA retention (accumulation and depuration) varies between species, meaning that not all fisheries are equally affected. Therefore, there is a need to better understand species-specific DA dynamics in order to effectively manage fisheries and mitigate economic impacts. Variegated scallops, Mimachlamys varia, have low DA levels compared to king scallops, Pecten maximus, although both occur in similar locations. However, there is a lack of knowledge on DA retention in M. varia, partly due to the difficulty of monitoring field-level individual contamination, and obtaining large volumes of toxic Pseudo-nitzschia species under laboratory conditions. This study summarises the information available from French monitoring networks for DA contamination in M. varia and investigates DA accumulation and depuration by experimental exposure. The in-situ monitoring revealed that M. varia can accumulate DA, but at lower concentrations than other bivalves at similar locations and times. The experimental exposure induced contamination and we estimated a high depuration rate of 3.3d^-1 for the digestive gland. These findings have implications for fisheries management and suggest that M. varia may be less susceptible to domoic acid-related effects than other pectinid species and could be an alternative resource.

01 Jul 2025·Journal of Hazardous Materials

Dissolved organic matter (DOM) – Driven variations of cadmium mobility and bioavailability in waterlogged paddy soil

Article

Author: Ma, Jingnan ; Ke, Xianlin ; Liu, Fulai ; Hu, Zhengyi ; Qiu, Yanhua ; Tao, Mingming ; Liu, Linlin

Cadmium (Cd) mobility and bioavailability in paddy soils are strongly influenced by dissolved organic matter (DOM), yet the mechanisms remain unclear. This study conducted a 90-day waterlogged soil incubation with DOM / sulfate amendments under varying Cd levels. Key parameters, including dissolved organic carbon (DOC), pe+pH, Fe/S - related parameters, alongside indicators of Cd mobility and bioavailability, were monitored. Results revealed that DOM addition increased Cd mobility on the 3rd day of incubation (DOI), irrespective of sulfate application, due to Cd desorption from iron oxides and DOM-Cd complexation. After the 10th DOI, DOM addition reduced Cd mobility and bioavailability mainly due to facilitation of sulfide-mediated Cd sequestration driven by Fe-S related reducing bacteria. The combined application with sulfate strengthened this effect. However, in low-Cd soils, DOM addition increased Cd bioavailability since the 45th DOI, likely due to the low Cd/DOM ratio, which limited sulfide immobilization. Nevertheless, sulfate application mitigated this effect. Furthermore, DOM supplementation generally decreased Cd mobility, but increased Cd availability at the 45th DOI in high-Cd soils due to competitive adsorption and Fe transformation. This study demonstrates the dual role of DOM in regulating Cd dynamics and its interaction with sulfate, offering insights for Cd contamination management in paddy soils.

01 Apr 2025·Ecotoxicology and Environmental Safety

Network toxicology and molecular docking reveal key mechanisms of domoic acid neurotoxicity with bio-layer interferometry validation

Article

Author: Lu, Feng ; Tang, Yuxiao ; Wang, Dongyao ; Shen, Hui ; Wang, Lianghua ; Yang, Wen ; Liu, Yiping ; Chen, Shitao ; Liu, Yan ; Lv, Diya

The study aims to promote a network toxicology strategy to efficiently investigate the underlying neurotoxicity molecular mechanisms of domoic acid（DA）, which is one of the main toxins of paralytic amnesic shellfish poisoning and has gained significant attention due to its ability to induce neurotoxicity. By utilizing ChEMBL, CTD, Drug bank, TTD, DGIdb, Pharmapper and GeneCards databases, we identified 73 potential targets associated with DA-exposure related amnesia and neurotoxicity. Further refinements via STRING and Cytoscape software highlight the protein-protein interactions. 30 targets were recognized by both the K-means algorithm and topological analysis. GO and KEGG pathway analysis conducted through DAVID databases reveals that these targets of amnesia and neurotoxicity are predominantly enriched in multiple pathways. AKT1 was identified by a multiple-topically methods as the key target. Molecular docking and bio-layer interferometry were conducted to confirm the binding between these targets and DA(-CDOCKER_INTERACTION_ENERGY =45.719 kcal/mol, K_D=2.0E-11M). This research provides a theoretical basis for understanding the molecular mechanism of DA-induced neurotoxicity, as well as establishing a foundation for the prevention and treatment of DA exposure.

100 Deals associated with Domoic acid

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