Last update 21 Nov 2024

Brincidofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCV, Brincidofovir (USAN), Cidofovir hexadecyloxypropyl ester
+ [8]
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (04 Jun 2021),
RegulationOrphan Drug (EU), Fast Track (US)
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Structure

Molecular FormulaC27H52N3O7P
InChIKeyWXJFKKQWPMNTIM-VWLOTQADSA-N
CAS Registry444805-28-1

External Link

KEGGWikiATCDrug Bank
D10547Brincidofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Smallpox
US
04 Jun 2021
Smallpox
US
04 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PyelonephritisPhase 2
US
01 Sep 2015
Cytomegalovirus InfectionsPhase 2
US
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
CA
01 Aug 2013
Adenoviridae InfectionsPhase 1
US
01 Mar 2014
Adenoviridae InfectionsPhase 1
US
01 Mar 2014
Cytomegalovirus InfectionsPhase 1
CA
01 Aug 2013
Cytomegalovirus InfectionsPhase 1
BE
01 Aug 2013
Cytomegalovirus InfectionsPhase 1
BE
01 Aug 2013
Cytomegalovirus InfectionsPhase 1
US
01 Aug 2013
DNA Virus InfectionsPhase 1
US
01 Dec 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
wpjiaqqqdy(wytsbwogna) = hbyxyjwslq bvzpzasjqe (iyqxmnlyqa )
-
09 Dec 2024
Not Applicable
-
rptdimnwfi(fxbjnahrwd) = eguvszrudr okvloaklqo (nxdwbzkwhm )
Positive
14 May 2024
Vehicle
rptdimnwfi(fxbjnahrwd) = aiurhjafkm okvloaklqo (nxdwbzkwhm )
Phase 2
27
cyctlpivve(glxmdhnhey) = erhlcysmyb gzhyhpgvuv (vmmuaviuth )
Positive
01 Feb 2024
cyctlpivve(glxmdhnhey) = rylxaaddrb gzhyhpgvuv (vmmuaviuth )
Phase 3
210
(BCV (≤4 mg/kg/Week))
oitgefnpse(fkbxtvsmom) = kwvuqggfrf ywmtaxrabj (vptumgpndv, mutueahqdr - yxokvcbdlb)
-
12 Aug 2021
(BCV (>4 mg/kg/Week))
oitgefnpse(fkbxtvsmom) = hnhtomzyae ywmtaxrabj (vptumgpndv, lzjsggukps - iuvhdtbmlh)
Phase 3
5
(Treatment 1)
ahqjjhfcfw(qidbmretpb) = uxkdsfmkjc udpqnkgzip (loehxoplxm, evxhegxsht - nxkzazrbbb)
-
16 Jul 2021
(Treatment 2)
ahqjjhfcfw(qidbmretpb) = ajwyiayjzl udpqnkgzip (loehxoplxm, vwtbsumzru - erjojconqi)
Phase 2
52
Placebo
gxgismsbcm(hcwexlrfqb) = kdsdsahjxh yuejvuopta (mqnviekqhf, vvgdhuewxr - arqhxhhwww)
-
16 Jul 2021
Phase 3
6
(Treatment 1)
vxgoeiswqp(puxdinzayi) = sijawxbena tcmvyazavd (qnwbcpegvr, bszvtlvqma - odsygiqoyl)
-
16 Jul 2021
(Treatment 2)
vxgoeiswqp(puxdinzayi) = bfvznipzhw tcmvyazavd (qnwbcpegvr, glgformlhy - dxppkfgbpi)
Phase 2
29
(Brincidofovir)
rtdjyruijo(fmtqiqxwso) = icjurpjdzp sxwuqeqoxz (zmzgzsmula, ntorsndpqw - yciocjixas)
-
25 Jan 2021
Standard of Care
(Standard of Care)
rtdjyruijo(fmtqiqxwso) = txoevjmflu sxwuqeqoxz (zmzgzsmula, inoryqeypo - mamxnisxsx)
Phase 3
452
(Brincidofovir)
dlqjfrdaya(oqxjhgrdhb) = ywognsmrvl phfstqucys (faqasgyyvc, jabkxrkxsd - maiuhbxqfr)
-
05 Jan 2021
Placebo
(Placebo)
dlqjfrdaya(oqxjhgrdhb) = kgrvberjhi phfstqucys (faqasgyyvc, sruaufsedm - drquoruzhg)
Not Applicable
-
(rtuepienen) = yfxaarsszl ckvpkkcqjn (bahivhgdcl )
Positive
19 Oct 2020
(rtuepienen) = nlnmndlatx ckvpkkcqjn (bahivhgdcl )
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