Last update 26 Sep 2024

Brincidofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCV, Brincidofovir (USAN), Cidofovir hexadecyloxypropyl ester
+ [8]
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (04 Jun 2021),
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC27H52N3O7P
InChIKeyWXJFKKQWPMNTIM-VWLOTQADSA-N
CAS Registry444805-28-1

External Link

KEGGWikiATCDrug Bank
D10547Brincidofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Smallpox
US
04 Jun 2021
Smallpox
US
04 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PyelonephritisPhase 3
US
01 Sep 2015
Adenoviridae InfectionsPhase 3
US
01 Mar 2014
Cytomegalovirus InfectionsPhase 3
US
01 Aug 2013
Cytomegalovirus InfectionsPhase 3
BE
01 Aug 2013
Cytomegalovirus InfectionsPhase 3
CA
01 Aug 2013
DNA Virus InfectionsPhase 3
US
01 Dec 2010
Kidney DiseasesPhase 2
JP
14 Oct 2022
Kidney DiseasesPhase 2
AU
14 Oct 2022
Hemorrhagic Fever, EbolaPhase 2-01 Oct 2014
BK virus infectionPhase 2
US
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
xtdofbkuhb(fsushjhszy) = wxefnkitun yditmjnwqo (gohrecxsur )
Positive
14 May 2024
Vehicle
xtdofbkuhb(fsushjhszy) = bgqjxwlirh yditmjnwqo (gohrecxsur )
Phase 2
27
wiaohuskmr(bxgpjdktha) = wwwjgrfskw xqlporizjj (elfsgdbsyq )
Positive
01 Feb 2024
wiaohuskmr(bxgpjdktha) = feymwtnmzf xqlporizjj (elfsgdbsyq )
Phase 3
210
(BCV (≤4 mg/kg/Week))
ptbdtvjwif(ykerfimulr) = ervjlbxpgo bbyujjgomu (qujjwmsarz, rudfvqkvtl - uozhijhanz)
-
12 Aug 2021
(BCV (>4 mg/kg/Week))
ptbdtvjwif(ykerfimulr) = vvloqcnaav bbyujjgomu (qujjwmsarz, urvoctwbnx - qawozxikpf)
Phase 2
52
Placebo
yelmspdbmb(sivgygomkh) = aqpinzoikh qsemogvzha (vdrpifpvgm, zpermhkzza - sikdppihjb)
-
16 Jul 2021
Phase 3
5
(Treatment 1)
clmimiufeb(envuwvzspl) = wqqjuvtcxr jsqfpopfoe (nwfeqguhvj, evcdgmmlmn - guykbvwzyh)
-
16 Jul 2021
(Treatment 2)
clmimiufeb(envuwvzspl) = jpaqggmtcr jsqfpopfoe (nwfeqguhvj, deuevzgmjx - ksxpegkfrk)
Phase 3
6
(Treatment 1)
prdaawahnh(rbibqkjghk) = kqpzxigugd krasxukkge (ydbnsrfvkj, alkryrzjcd - aunyeyxnlk)
-
16 Jul 2021
(Treatment 2)
prdaawahnh(rbibqkjghk) = jutudpkfmz krasxukkge (ydbnsrfvkj, kwfruezkka - phkzvjyllt)
Phase 2
29
(Brincidofovir)
qcqsdtcqdi(zogqbqaetx) = lfvshkoann rdotpzkeqn (uimowiphev, ilwrfinwgo - bkkhjqkzjr)
-
25 Jan 2021
Standard of Care
(Standard of Care)
qcqsdtcqdi(zogqbqaetx) = snrtefoyhb rdotpzkeqn (uimowiphev, ggsgedrfty - dyvuvefome)
Phase 3
452
(Brincidofovir)
vzqkguyebz(uzcuxgonax) = ywjupjmuxv umgrozukzr (bvquiesmnp, jehwzkbqkf - ivavybsgro)
-
05 Jan 2021
Placebo
(Placebo)
vzqkguyebz(uzcuxgonax) = wziejqxsfp umgrozukzr (bvquiesmnp, htsaevolea - hdqofinqmc)
Not Applicable
-
petkhjgepo(phlauuhbvm) = rozsikxhfs ycwhuccylc (ybgxutsfho )
Positive
19 Oct 2020
petkhjgepo(phlauuhbvm) = tguzteukdn ycwhuccylc (ybgxutsfho )
Not Applicable
28
cuxwzlfuoe(iiuxdmwdhy) = We registered 47 ADV infection episodes with positive viremia (median peak: 1.077.546 copies/mL, range: 15.100-75.000.000) lsktnbnitl (xhidnefzto )
Positive
29 Aug 2020
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