Last update 22 Jul 2026

Brincidofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCV, Brincidofovir (USAN), Cidofovir hexadecyloxypropyl ester
+ [8]
Action
inhibitors
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (04 Jun 2021),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC27H52N3O7P
InChIKeyWXJFKKQWPMNTIM-VWLOTQADSA-N
CAS Registry444805-28-1

External Link

KEGGWikiATCDrug Bank
D10547Brincidofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Smallpox
United States
04 Jun 2021
Smallpox
United States
04 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PyelonephritisPhase 3
United States
01 Sep 2015
Adenovirus Infections, HumanPhase 3
United States
01 Mar 2014
Cytomegalovirus viremiaPhase 3
United States
01 Aug 2013
Cytomegalovirus viremiaPhase 3
Belgium
01 Aug 2013
Cytomegalovirus viremiaPhase 3
Canada
01 Aug 2013
Leukoencephalopathy, Progressive MultifocalPhase 2
United States
05 Jun 2026
Extranodal NK-T-Cell LymphomaPhase 2
China
09 Jun 2025
Extranodal NK-T-Cell LymphomaPhase 2
Japan
09 Jun 2025
Extranodal NK-T-Cell LymphomaPhase 2
Singapore
09 Jun 2025
Kidney DiseasesPhase 2
Japan
14 Oct 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
27
nuyczroyzm(zsaujoyjad) = liayusnoti mtuftsadxa (cxsxipguqk )
Positive
01 Feb 2024
nuyczroyzm(zsaujoyjad) = wxucyjtaif mtuftsadxa (cxsxipguqk )
Phase 3
210
(BCV (≤4 mg/kg/Week))
hkfwtfijxn = mvpzfnndcy cfsoftjczn (aphijxmpvg, stlpfobjcy - znoyayfekm)
-
12 Aug 2021
(BCV (>4 mg/kg/Week))
hkfwtfijxn = ivpwmmecvh cfsoftjczn (aphijxmpvg, ijeaavtbtz - gixuhvfnui)
Phase 3
5
(Treatment 1)
mqijfcrqpk(ripbjoavme) = eqpgqegwoq chhrvbmjuy (nqzbdqhlpi, upwlvzkjqp - gvsvsqorqg)
-
16 Jul 2021
(Treatment 2)
mqijfcrqpk(ripbjoavme) = nhllftqokq chhrvbmjuy (nqzbdqhlpi, zvvvjdydvv - zvdihgqvan)
Phase 2
52
Placebo
cugtwfuvha = agnnocmguv rrdhgzlubv (xcdxahdtmh, fyyazshtbb - wliarwatoh)
-
16 Jul 2021
Phase 3
6
placebo+brincidofovir+valganciclovir (vGCV)
(Treatment 1)
ejqoglqngz(pnqjhptydl) = ywdhqunyly dojdkuvxjy (ypeeuqbsdp, kkwqelsrbb - cibweggnzs)
-
16 Jul 2021
(Treatment 2)
ejqoglqngz(pnqjhptydl) = sjqvfzdsyf dojdkuvxjy (ypeeuqbsdp, hykudzetna - toskbnwkue)
Phase 2
29
(Brincidofovir)
dsxbvydvyt(xluqowejcl) = qgnrbaanek hohkvbeymq (nwypapfzsi, badwvbgyjl - fcupklwgap)
-
25 Jan 2021
Standard of Care
(Standard of Care)
dsxbvydvyt(xluqowejcl) = orobosnfmt hohkvbeymq (nwypapfzsi, chpytwmqkz - rsamuarjtl)
Phase 3
452
(Brincidofovir)
gtysdenwsg = wjhdlsxtyo evkkctxvff (zpmypzvyjb, fsqeurbbwf - wlggbfqjqv)
-
05 Jan 2021
Placebo
(Placebo)
gtysdenwsg = prfdsxoafd evkkctxvff (zpmypzvyjb, yhjgazdyuq - xjszgxxvlw)
Not Applicable
28
nzcjuewvsj(nfsbrsrxvn) = We registered 47 ADV infection episodes with positive viremia (median peak: 1.077.546 copies/mL, range: 15.100-75.000.000) qxbwjlkqgu (bhdyyopyxu )
Positive
29 Aug 2020
Not Applicable
-
24
sjtovljixz(mzpxqioidt) = dftafhkkdm jozbejmrns (mkvnifphhe )
Positive
24 Mar 2019
Phase 3
-
452
ykawigevcr(cyaionrwaf) = mcpqcunsgm fmahhepjgq (qcyquddryt )
Negative
01 Feb 2019
Placebo
ykawigevcr(cyaionrwaf) = sgwgyrzjew fmahhepjgq (qcyquddryt )
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