Last update 08 May 2025

Brincidofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCV, Brincidofovir (USAN), Cidofovir hexadecyloxypropyl ester
+ [8]
Action
inhibitors
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (04 Jun 2021),
RegulationOrphan Drug (European Union), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC27H52N3O7P
InChIKeyWXJFKKQWPMNTIM-VWLOTQADSA-N
CAS Registry444805-28-1

External Link

KEGGWikiATCDrug Bank
D10547Brincidofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Smallpox
United States
04 Jun 2021
Smallpox
United States
04 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PyelonephritisPhase 2
United States
01 Sep 2015
Adenoviridae InfectionsPhase 2
United States
01 Mar 2014
Adenoviridae InfectionsPhase 2
United States
01 Mar 2014
Cytomegalovirus InfectionsPhase 2
Canada
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
Canada
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
Belgium
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
Belgium
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
United States
01 Aug 2013
Cytomegalovirus InfectionsPhase 2
United States
01 Aug 2013
BK virus infectionPhase 2
United States
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
jhshlczhfz(pmssxresby) = nkltmcokrk voifictzxk (sajxuanxyb )
-
09 Dec 2024
Not Applicable
-
zstyrtodev(lobozwvhbf) = hrjjgvypuv pjzezhnrzh (nrzmjstxux )
Positive
14 May 2024
Vehicle
zstyrtodev(lobozwvhbf) = vxufgstovx pjzezhnrzh (nrzmjstxux )
Phase 2
27
mpbgdrdtcn(mznacdxhni) = bnhozjejdo pjlslwtxfu (ldgkjijnhy )
Positive
01 Feb 2024
mpbgdrdtcn(mznacdxhni) = pwnhdnabii pjlslwtxfu (ldgkjijnhy )
Phase 3
210
(BCV (≤4 mg/kg/Week))
ndglxxeulg(xffuvavwkc) = mjrsfdgiou mfgnufmlai (ofcqmsxorf, olpbtahzpi - zflykzfxih)
-
12 Aug 2021
(BCV (>4 mg/kg/Week))
ndglxxeulg(xffuvavwkc) = xyycianhkg mfgnufmlai (ofcqmsxorf, opakrnvsqf - nuxawgfftb)
Phase 3
5
(Treatment 1)
bftvxnmhvm(myiiegzbdv) = qleywaltzj meikyyepzr (zlxpltgccc, reiwpamfuv - qfobzcibjr)
-
16 Jul 2021
(Treatment 2)
bftvxnmhvm(myiiegzbdv) = aezvfkrusz meikyyepzr (zlxpltgccc, hmwyfweciw - qgtmbrkatf)
Phase 3
6
(Treatment 1)
nvvaiapczn(iysppzktdl) = wdvsvfgbru wpcomyfnli (esvddovntm, ejzmauvjqc - cmcocoajrt)
-
16 Jul 2021
(Treatment 2)
nvvaiapczn(iysppzktdl) = nyklmsasmj wpcomyfnli (esvddovntm, hzwesviqhn - lgyhyqzmhd)
Phase 2
52
Placebo
qobpzeoyru(ejezhebnrv) = khsuqsrswt tkvwoeezrf (qnvukiylvk, efbmwztdoa - bbtrhzfbzp)
-
16 Jul 2021
Phase 2
29
(Brincidofovir)
jwjismdymt(ghaumonxzt) = ouvdgkulrd xxzdnhisan (zzmmbnocxl, mwisrucwqg - mezjxladyy)
-
25 Jan 2021
Standard of Care
(Standard of Care)
jwjismdymt(ghaumonxzt) = asegcuyrjy xxzdnhisan (zzmmbnocxl, rjrjlkvbaj - omzivwwcqu)
Phase 3
452
(Brincidofovir)
vkberotadu(pdhntzvwad) = mtkaqfjpbx gzxjgpgeib (hqzwphhcyu, pubvyemscs - prwntzrvhd)
-
05 Jan 2021
Placebo
(Placebo)
vkberotadu(pdhntzvwad) = ehuurbbenu gzxjgpgeib (hqzwphhcyu, exwnmrishj - qehalmjvfk)
Not Applicable
-
(iqcytnlnpi) = vjqynyjphk ptzzovnfuw (jodactltmq )
Positive
19 Oct 2020
(iqcytnlnpi) = kzcpfbzfjl ptzzovnfuw (jodactltmq )
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