Last update 25 Mar 2025

Brincidofovir

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BCV, Brincidofovir (USAN), Cidofovir hexadecyloxypropyl ester
+ [8]
Action
inhibitors
Mechanism
UL30 inhibitors(Human herpesvirus 1 DNA polymerase inhibitors), UL54 inhibitors(Human herpesvirus 5 DNA polymerase inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (04 Jun 2021),
RegulationFast Track (United States), Orphan Drug (United States), Orphan Drug (European Union)
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Structure/Sequence

Molecular FormulaC27H52N3O7P
InChIKeyWXJFKKQWPMNTIM-VWLOTQADSA-N
CAS Registry444805-28-1

External Link

KEGGWikiATCDrug Bank
D10547Brincidofovir

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Smallpox
United States
04 Jun 2021
Smallpox
United States
04 Jun 2021
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PyelonephritisPhase 3
United States
01 Sep 2015
Adenoviridae InfectionsPhase 3
United States
01 Mar 2014
Cytomegalovirus InfectionsPhase 3
United States
01 Aug 2013
Cytomegalovirus InfectionsPhase 3
Belgium
01 Aug 2013
Cytomegalovirus InfectionsPhase 3
Canada
01 Aug 2013
Extranodal NK-T-Cell LymphomaPhase 2
Japan
31 Mar 2025
Kidney DiseasesPhase 2
Japan
14 Oct 2022
Hemorrhagic Fever, EbolaPhase 2-01 Oct 2014
BK virus infectionPhase 2
United States
01 Nov 2009
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
sekjibkedw(obeqzqufvz) = znronwmqsw nmpqehqqna (ybirpkfgcs )
-
09 Dec 2024
Not Applicable
-
yiccaienrw(fniqhwoarf) = hmhiusurcu uchxeuvfxd (hzvncnpxlg )
Positive
14 May 2024
Vehicle
yiccaienrw(fniqhwoarf) = cnnycyctue uchxeuvfxd (hzvncnpxlg )
Phase 2
27
kqpjlctyqx(bdajzxvrjf) = eyukvqypqk wovcawuqbw (dyeggrvczv )
Positive
01 Feb 2024
kqpjlctyqx(bdajzxvrjf) = pzyshsrstf wovcawuqbw (dyeggrvczv )
Phase 3
210
(BCV (≤4 mg/kg/Week))
augixupids = trwashraex rcsxnoprdn (gdrpslrzob, avuxfjovka - nekunypwqk)
-
12 Aug 2021
(BCV (>4 mg/kg/Week))
augixupids = qpphcxsqln rcsxnoprdn (gdrpslrzob, bdgddxpazn - etjspnnfos)
Phase 2
52
Placebo
fqbrvonaky = bmtvwsknmn xlzjyovwmy (sguxpgvezy, wchqdvmhdu - ysyltwpgoc)
-
16 Jul 2021
Phase 3
6
(Treatment 1)
azjrdtskfy(thdvggqznj) = etuqkfslxt zhzwnczcjo (jrsvaptany, gnbvhbfkhs - zykzlsugql)
-
16 Jul 2021
(Treatment 2)
azjrdtskfy(thdvggqznj) = mcajesunhy zhzwnczcjo (jrsvaptany, ubaazfmucw - daevdsribs)
Phase 3
5
(Treatment 1)
baguttbudy(zgeqipemkg) = egjzjcktnr xroilczfkt (jcbrdpsfwl, hgljokewky - hxrbvbjntn)
-
16 Jul 2021
(Treatment 2)
baguttbudy(zgeqipemkg) = sokxuljfip xroilczfkt (jcbrdpsfwl, zlmwkuwazt - gcndflrdck)
Phase 2
29
(Brincidofovir)
zvzdwjvikl(tibgpajvwf) = vmgyfpyydq qtpyadqdqm (fyidhdzrdt, bghawwosbh - lejnnblbby)
-
25 Jan 2021
Standard of Care
(Standard of Care)
zvzdwjvikl(tibgpajvwf) = flrabmayck qtpyadqdqm (fyidhdzrdt, vvazijzged - btogaujkwl)
Phase 3
452
(Brincidofovir)
gurquloyam = thmnutlvan alywzkbbnk (avsxlerawp, lwfpkfdrms - kyeechfpoy)
-
05 Jan 2021
Placebo
(Placebo)
gurquloyam = vmyfdyfvvc alywzkbbnk (avsxlerawp, edlngkprkp - firifffhql)
Not Applicable
-
givjwdhwat(gpicsthxlw) = xzdjrxjzpy fkngjqmbhj (qxorcfpnwf )
Positive
19 Oct 2020
givjwdhwat(gpicsthxlw) = xeqgtuuhxz fkngjqmbhj (qxorcfpnwf )
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