Delving into the Latest Updates on α-globin restored autologous hematopoietic stem cells(Shenzhen Hemogen) with Synapse

Overview

Basic Info

Drug Type

CRISPR/Cas9

Synonyms

Target

Hemoglobin HbA

Mechanism

Hemoglobin HbA modulators

Therapeutic Areas

Congenital DisordersHemic and Lymphatic DiseasesOther Diseases

Active Indication

Alpha-Thalassemia

Inactive Indication-

Originator Organization

Shenzhen Hemu Gene Biotechnology Co. Ltd.

Active Organization

Shenzhen Hemu Gene Biotechnology Co. Ltd.

Inactive Organization-

Drug Highest PhaseEarly Phase 1

First Approval Date-

Regulation-

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Muscle fibers and myosin B threads shortened in neutral K₂HgI₄ solutionThe speed and extent of shortening of psoas muscle fibers depended on the concentration of the reagent.KI was shown to be the contracting agent, but its action was counterbalanced by an elongation process which could be eliminated by HgI₂.Similar results were obtained with KSCN and HgI₂.In addition to shortening the fibers, the reagents made them very elastic.Stretched fibers freed of reagent remained "set," and shortened again when treated with the reagent.Myosin B threads behaved like muscle fibers.

01 Jan 1928·Biochemical JournalQ3 · BIOLOGY

The effect of metallic salts on the glycolysis and respiration of tissues

Q3 · BIOLOGY

Article

Author: Jowett, Maurice ; Brooks, John

The toxicity to glucolysis is in the order HgI₂, HgCl₂ > Cu > Zn > Cl > Ca.At low concentrations Pb⁺⁺ slightly accelerates glucolysis of malignant tissues and accelerates their respiration if at much higher concentrationsGlucolysis appears to be more sensitive than respiration to heavy metals in the case of malignant tissue.For normal tissues the converse is true.

100 Deals associated with α-globin restored autologous hematopoietic stem cells(Shenzhen Hemogen)

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