Delving into the Latest Updates on Shenzhen Hemu Gene Biotechnology Co. Ltd. with Synapse

Overview

Tags

Congenital Disorders

Other Diseases

Hemic and Lymphatic Diseases

CRISPR/Cas

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Hemic and Lymphatic Diseases	3
Immune System Diseases	2
Endocrinology and Metabolic Disease	1
Nervous System Diseases	1

Top 5 Drug Type	Count

CRISPR/Cas	5

Top 5 Target	Count

β-globin(Hemoglobin beta chain)	1
ASA(Cerebroside-sulfatase)	1
Hemoglobin HbA	1
IL-2Rγ(Interleukin-2 receptor subunit gamma)	1

This is a single-arm, open label, multi-center, single-dose Phase 1 clinical trial in subjects with transfusion dependent β-thalassaemia. The study aims to evaluate the safety and efficacy of autologous lentiviral-transduced CD34+ human hematopoietic stem cells (hHSCs) using the gene therapy product HGI-001.

Start Date12 Jun 2024

Sponsor / Collaborator

Shenzhen Hemu Gene Biotechnology Co. Ltd.

NCT05851105 / RecruitingEarly Phase 1

the Safety and Efficacy Evaluation of HGI-002 Injection in Patients With Transfusion-Dependent α-Thalassemia

This is an open label study to evaluate the safety and efficacy of α-globin Restored Autologous Hematopoietic Stem Cells in α-Thalassemia Major Patients

Start Date08 Oct 2022

Sponsor / Collaborator

Shenzhen Hemu Gene Biotechnology Co. Ltd.

NCT05864170 / RecruitingEarly Phase 1

the Safety and Efficacy Evaluation of HGI-001 Injection in Patients With Transfusion-Dependent β-Thalassemia(Child)

This is an open label study to evaluate the safety and efficacy of β-globin Restored Autologous Hematopoietic Stem Cells in ß-Thalassemia Major Patients

Start Date27 May 2022

Sponsor / Collaborator

Shenzhen Hemu Gene Biotechnology Co. Ltd.

100 Clinical Results associated with Shenzhen Hemu Gene Biotechnology Co. Ltd.

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0 Patents (Medical) associated with Shenzhen Hemu Gene Biotechnology Co. Ltd.

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100 Deals associated with Shenzhen Hemu Gene Biotechnology Co. Ltd.

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100 Translational Medicine associated with Shenzhen Hemu Gene Biotechnology Co. Ltd.

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Pipeline

Pipeline Snapshot as of 23 Dec 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Preclinical

3

1

Phase 1 Clinical

Phase 2 Clinical

1

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

β-globin restored autologous hematopoietic stem cells (Hemogen Gene) ( β-globin )	Transfusion-dependent Beta Thalassemia More	Phase 2 Clinical
α-globin restored autologous hematopoietic stem cells(Shenzhen Hemogen) ( Hemoglobin HbA )	Alpha-Thalassemia More	Phase 1 Clinical
HGI-005 ( ASA )	Neurodegenerative Diseases More	Preclinical
HGI-004	Wiskott-Aldrich Syndrome More	Preclinical
HGI-003 ( IL-2Rγ )	X-Linked Combined Immunodeficiency Diseases More	Preclinical