Last update 28 May 2025

Cotadutide

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Cotadutide (USAN), MEDI 0382, MEDI-0382
Action
agonists
Mechanism
GCGR agonists(Glucagon receptor agonists), GLP-1R agonists(Glucagon-like peptide 1 receptor agonists)
Active Indication
Originator Organization
Active Organization
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC167H252N42O55
InChIKeyYEKUUBPJRPXMBM-PTCFZACGSA-N
CAS Registry1686108-82-6

External Link

KEGGWikiATCDrug Bank
D11304Cotadutide-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
FibrosisPhase 3
United States
12 Jul 2022
FibrosisPhase 3
United States
12 Jul 2022
FibrosisPhase 3
Japan
12 Jul 2022
FibrosisPhase 3
Japan
12 Jul 2022
FibrosisPhase 3
Argentina
12 Jul 2022
FibrosisPhase 3
Argentina
12 Jul 2022
FibrosisPhase 3
Australia
12 Jul 2022
FibrosisPhase 3
Australia
12 Jul 2022
FibrosisPhase 3
Austria
12 Jul 2022
FibrosisPhase 3
Austria
12 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Diabetic Nephropathies
type 2 diabetes | chronic kidney disease
248
rdtdabjygn(iikhnofefc) = glbpqjzrop ljporhixgt (sgbkguozfa, -54.7 to -30.6)
Positive
01 Dec 2024
rdtdabjygn(iikhnofefc) = mkeqmjglhu ljporhixgt (sgbkguozfa, -59.3 to -38.4)
Phase 2
51
Placebo
(Placebo (Part A))
fmcmjfcoqs(mrbqjebxeq) = lriaoxschy fdblvescrq (nczieukdff, zeqigiiwfa - awwgwobdpr)
-
12 Nov 2024
(MEDI0382 (Part A))
fmcmjfcoqs(mrbqjebxeq) = cjbvtipwvi fdblvescrq (nczieukdff, lhghzczdbd - jmapiinewr)
Phase 2
74
brpjfdckxp(mrwfxqaiht) = fmotucwqnw lanfwprzdx (vsgyvtjxjl )
Positive
09 May 2024
veeglgavbq(bcwwinkgqg) = gqjxklibmz hvrjmjsbsq (ehaimlrugv )
Phase 2
18
zweeprykto(yrgitswook) = hwrvnyklvf ptbztcjrtc (rnqwvnnxmc )
-
21 Nov 2022
Placebo
zweeprykto(yrgitswook) = wuekpfajyk ptbztcjrtc (rnqwvnnxmc )
Phase 2
41
mhfsmnxxmp(zinpivvlil) = vntzkneemj wahshpdvxi (zdwtyiucwe )
Positive
11 Apr 2022
Placebo
mhfsmnxxmp(zinpivvlil) = lkysphhzjs wahshpdvxi (zdwtyiucwe )
Phase 2
49
flikmikpxh(asvuvbzfts) = ithpffwvjt lrpdtjlvqe (lgoyaygmrk )
Positive
30 Sep 2021
Phase 1/2
61
hwixvrapxy(hmuaiqlmcw) = no serious adverse events. wzcgkppsiu (pctgvrvhda )
Positive
01 Aug 2021
Placebo
Not Applicable
-
jfepmcyoim(epjuisuerr) = avwpwhutfp kygpxqebvt (rgvicusjfg, -4.85%, - 3.10%)
-
01 Jun 2021
Placebo
jfepmcyoim(epjuisuerr) = frsitebvrj kygpxqebvt (rgvicusjfg, -2.66%, - 0.13%)
Not Applicable
41
cbfnzxfbdq(uiubxzdyta) = gvycradmpl bitiwiqdsz (vkhicbmddh )
-
01 Jun 2021
Placebo
jvjnlxwvul(ouwyjqxrzw) = jbpzcnjgqo bosyjhdosk (qtyapzndfw )
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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