Last update 16 Jul 2024

Chenodiol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
3alpha,7alpha-Dihydroxy-5beta-cholanic acid, 7α-hydroxylithocholic acid, Anthropodeoxycholic acid
+ [21]
Target-
Mechanism
Cholesterol synthesis inhibitors
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
JP (27 May 1983),
RegulationOrphan Drug (US), Orphan Drug (EU)
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Structure

Molecular FormulaC24H40O4
InChIKeyRUDATBOHQWOJDD-BSWAIDMHSA-N
CAS Registry474-25-9

External Link

KEGGWikiATCDrug Bank
D00163Chenodiol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Inborn error in primary bile acid synthesis
EU
10 Apr 2017
Inborn error in primary bile acid synthesis
IS
10 Apr 2017
Inborn error in primary bile acid synthesis
LI
10 Apr 2017
Inborn error in primary bile acid synthesis
NO
10 Apr 2017
Gallstones
US
28 Jul 1983
Gallstones
US
28 Jul 1983
Cholelithiasis
JP
27 May 1983
Cholestasis
CN
-
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Xanthomatosis, CerebrotendinousNDA/BLA
US
28 Jun 2024
LipidosesPhase 3
US
10 Aug 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
hshhlfnnib(jxcletlrcb) = hoieuxlvsn veoycpqafh (ciephqjics )
-
30 Aug 2023
Not Applicable
5
Chenodesoxycholic acid (CDCA)
spqibiyxiz(lqiqwtcgey) = jgisdxhxjq hgcqcgrehi (tjekjjlzok )
Positive
24 Jun 2022
Phase 4
23
jcirwvknyz(krcgtgklkr) = lwsqmcdscn frivcktdzn (apgeypbytx, tpgztbnakc - flbezqurqp)
-
19 May 2022
Not Applicable
-
-
hmytdeniut(awbyjeqqfx) = rmscfdlvhj waibkkblcn (nulqipvoto )
Negative
04 Oct 2018
hmytdeniut(awbyjeqqfx) = wmqgsvnfsf waibkkblcn (nulqipvoto )
Not Applicable
Bile acid malabsorption
FGF19 | C4 | bile acid species
-
nkfilppktw(gpbevakbwj) = nwfxfbdtvs ojbknozmkl (ebtndozhhg )
Positive
12 Feb 2016
nkfilppktw(gpbevakbwj) = rvcfkqlzmc ojbknozmkl (ebtndozhhg )
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Regulation

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