Last update 21 Nov 2024

Setogepram

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fezagepras
Mechanism
GPR40 agonists(Free fatty acid receptor 1 agonists), GPR84 inhibitors(G-protein coupled receptor 84 inhibitors), Autophagy stimulants(Autophagy stimulants)
+ [3]
Inactive Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC13H18O2
InChIKeyPEGQOIGYZLJMIB-UHFFFAOYSA-N
CAS Registry1002101-19-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alstrom SyndromePhase 3--
Diabetes Mellitus, Type 2Preclinical
CA
01 May 2015
Metabolic SyndromePreclinical
CA
01 May 2015
Diabetes MellitusDiscovery
GB
22 Feb 2016
Diabetes MellitusDiscovery
GB
22 Feb 2016
InflammationDiscovery
GB
22 Feb 2016
ObesityDiscovery
GB
22 Feb 2016
Idiopathic Pulmonary FibrosisDiscovery
CA
01 Jul 2015
Diabetes Mellitus, Type 2Discovery
CA
01 May 2015
Metabolic SyndromeDiscovery
CA
01 May 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
rkiuqmonkp(uccgeawemh) = PAS-staining revealed decreased tubular injury and cyst formation in the adenine+PBI-4050 group compared to adenine+vehicle ohuqnbangg (cnocklipml )
Positive
31 Oct 2017
Water (vehicle)
Phase 2
Renal fibrosis
IL-18 | resistin | pentraxin-3
-
(pfcjkywtjj) = jnrsowlzec kiyoyjrrdf (ppbqmohllt )
Positive
15 Nov 2016
Phase 1/2
β-2-microglobulin | calbindin | cystatin C ...
-
(wsunqubrru) = uofctubomy snjrpkugey (tkrwruvkoj )
Positive
14 May 2016
Phase 1
-
(ekbcxbcdch) = There was a 34% decrease in the area under the curve (AUC 0-inf ) after a fat meal rreqdfpvdr (ngwhiadwtq )
Positive
03 Nov 2015
Phase 1/2
-
sqdnaedzef(sgeubfsetm) = PBI-4050 treatment inhibited the infiltration of macrophages in both kidney and pancreas ytbwjoloky (tkvyvcqxln )
Positive
21 May 2015
Vehicle (water)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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