Last update 01 Nov 2024

Setogepram

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Fezagepras
Mechanism
GPR40 agonists(Free fatty acid receptor 1 agonists), GPR84 inhibitors(G-protein coupled receptor 84 inhibitors), Autophagy stimulants(Autophagy stimulants)
+ [3]
Inactive Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
Regulation-
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Structure

Molecular FormulaC13H18O2
InChIKeyPEGQOIGYZLJMIB-UHFFFAOYSA-N
CAS Registry1002101-19-0
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alstrom SyndromePhase 3--
ArthritisPhase 1
GB
22 Feb 2016
Diabetes MellitusPhase 1
GB
22 Feb 2016
Diabetes MellitusPhase 1
GB
22 Feb 2016
ObesityPhase 1
GB
22 Feb 2016
Idiopathic Pulmonary FibrosisPhase 1
CA
01 Jul 2015
Diabetes Mellitus, Type 2Phase 1
CA
01 May 2015
Metabolic SyndromePhase 1
CA
01 May 2015
Diabetes Mellitus, Type 2Preclinical
CA
01 May 2015
Metabolic SyndromePreclinical
CA
01 May 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
-
odmcbmwcac(nnwbpzdets) = PAS-staining revealed decreased tubular injury and cyst formation in the adenine+PBI-4050 group compared to adenine+vehicle yiefnlupop (dlcttlbcbx )
Positive
31 Oct 2017
Water (vehicle)
Phase 2
Renal fibrosis
IL-18 | resistin | pentraxin-3
-
(cbuzvvgmee) = inlhjjkphs itutqzcmhp (rxsibpgfpb )
Positive
15 Nov 2016
Phase 1/2
β-2-microglobulin | calbindin | cystatin C ...
-
(fsyihutvlb) = dvesfkoviq crpvqdkpyf (qwvrtsrzps )
Positive
14 May 2016
Phase 1
-
(udbchuvupo) = There was a 34% decrease in the area under the curve (AUC 0-inf ) after a fat meal kviyfhkdlm (dmizwwwrvt )
Positive
03 Nov 2015
Phase 1/2
-
nxnicwibmp(dixztwueih) = PBI-4050 treatment inhibited the infiltration of macrophages in both kidney and pancreas nrtrolzgnb (riwglfhgyh )
Positive
21 May 2015
Vehicle (water)
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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