Last update 21 Nov 2024

Olodaterol Hydrochloride/Tiotropium Bromide

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BI-1744-CL/tiotropium bromide, Olodaterol Hydrochloride/Tiotropium Bromide Hydrate, Olodaterol/tiotropium bromide
+ [15]
Mechanism
M3 receptor antagonists(Muscarinic acetylcholine receptor M3 antagonists), β2-adrenergic receptor agonists(Beta-2 adrenergic receptor agonists)
Therapeutic Areas
Inactive Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationSpecial Review Project (CN), Priority Review (CN)
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Structure

Molecular FormulaC21H27ClN2O5
InChIKeyKCEHVJZZIGJAAW-FERBBOLQSA-N
CAS Registry869477-96-3
View All Structures (2)

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Pulmonary Disease, Chronic Obstructive
US
21 May 2015
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
AsthmaPreclinical-01 Oct 1998
Pulmonary Disease, Chronic ObstructiveDiscovery
RO
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
ZA
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
JP
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
HR
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
CA
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
BE
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
IN
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
RS
15 Sep 2010
Pulmonary Disease, Chronic ObstructiveDiscovery
ES
15 Sep 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
(yvcaotkvfg) = kkvwuotaia knmrlyktni (qdltmxgbli, 0.86 - 1.0)
-
01 Jul 2023
Not Applicable
1,255
(lqsehoemoe) = zqmqksgrsk cvifflvvro (zjzgbocpgm )
-
10 Aug 2022
Phase 4
14
(wcjujfhfrz) = bstntgvuva pcyzcotkzt (dgqvprpzph )
Negative
24 Mar 2022
Placebo
(wcjujfhfrz) = ukaokfofra pcyzcotkzt (dgqvprpzph )
Phase 4
714
LABA (Long-Acting Beta Agonist) (Triple therapy)
aycsyaezea(shnrtpgoez) = vezyrewfvc gouijzkqvv (mabblfebgt, letnfbwelv - rcylkqkqnr)
-
09 Dec 2021
Not Applicable
1,322
snenvvpjvh(heiopplzck) = tlxewmlvvm hjjxlxvpxo (ozwidwnhyq )
-
01 Jul 2021
Not Applicable
2,055
(nhhpjvnuio): HR = 0.76 (95% CI, 0.68 - 0.85)
Positive
01 Jan 2021
Not Applicable
80
ijkaaidlav(mvkngevgpz) = dafqngxwhv xorbqstmnc (jzysyjbftk )
-
07 Sep 2020
ijkaaidlav(mvkngevgpz) = hupdqopful xorbqstmnc (jzysyjbftk )
Phase 3
9,942
ljvgaehuup(ddxgvciurc) = zgxjffeica vylwzjxndd (fvtjyadhyc )
Positive
10 Aug 2020
ljvgaehuup(ddxgvciurc) = iyhentevbu vylwzjxndd (fvtjyadhyc )
Phase 3
1,078
akupisloyp(gdvhzyoaom) = uihrqwymqe xznxokmsgz (trhgtrjvdr, 0.033 - 0.079)
-
15 Jul 2020
Phase 4
14
Placebo Respimat+Stiolto Respimat
(Stiolto Respimat)
lkvobzhwzc(hyzortycmm) = wvvcrhmxpv lgzljxyqbh (zttkehnjql, kzpxzhzsjw - vdhjxfdzmu)
-
16 Jun 2020
Placebo Respimat+Stiolto Respimat
(Placebo Respimat)
lkvobzhwzc(hyzortycmm) = pscplsicld lgzljxyqbh (zttkehnjql, iypxwahgdc - zmerbazbup)
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Core Patent

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Clinical Trial

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Approval

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Regulation

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