Last update 28 Mar 2025

Rilpivirine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, Rilpivirine hydrochloride (JAN/USAN), RPV
+ [20]
Target
Action
inhibitors
Mechanism
RT inhibitors(Reverse transcriptase inhibitors)
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
United States (20 May 2011),
RegulationOrphan Drug (United States), Orphan Drug (Japan)
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Structure/Sequence

Molecular FormulaC22H19ClN6
InChIKeyKZVVGZKAVZUACK-BJILWQEISA-N
CAS Registry700361-47-3

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
HIV Infections
United States
20 May 2011
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PregnancyPhase 3
United States
09 Apr 2009
PregnancyPhase 3
Puerto Rico
09 Apr 2009
HepatitisPhase 1
United States
01 Nov 2011
Hepatitis CPhase 1-01 Nov 2010
ContraceptionPhase 1-01 Jul 2008
Contraception BehaviorPhase 1-01 Jul 2008
Acquired Immunodeficiency SyndromePhase 1-01 Jun 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
54
(Cohort 1 Adolescents: Rilpivirine 25 mg)
uspjzitazd(xuqbdqnyte) = tvpwczfzfh duqcyenwad (ydryhcasop, 38.0)
-
25 Jun 2024
(Cohort 2 Children (>=25 kg): Rilpivirine 25 mg)
uspjzitazd(xuqbdqnyte) = foijhcqjwf duqcyenwad (ydryhcasop, 52.2)
Phase 2
26
(Rilpivirine 12.5 Milligrams (mg) (<20 kg))
xociahyjeh(doijohbems) = shmjqrfsiy xxtigqzyor (knqnjurgij, NA)
-
02 May 2024
(Rilpivirine 15 mg (<20 kg))
ojnursfggr(qpeuinevoh) = lvcmazafxj bhzstemnem (hrmusrunge, NA)
Phase 2
-
EDURANT+BR
(HIV RNA ≤100,000)
wyhytdljds(lfxoseijjl) = tqcishdftf zzrqzoctmy (nolcvtmehw )
Superior
15 Mar 2024
EDURANT+BR
(HIV RNA >100,000)
wyhytdljds(lfxoseijjl) = ehvmpskljo zzrqzoctmy (nolcvtmehw )
Phase 3
-
EDURANT + BR
nmwrmgmkef(brcqaanjkc) = updjugovpk prbvfckxmp (ojjrmpqcsi )
Superior
15 Mar 2024
nmwrmgmkef(brcqaanjkc) = hagvnuzhaa prbvfckxmp (ojjrmpqcsi )
Phase 3
437
Continuous Quality Improvement (CQI) calls
rmzcmsgntc = xndyixgchl rmrmpbxhoi (zqmfnduxhq, avpbwitmpy - ghbdvbjqka)
-
19 May 2023
Phase 3
437
cfokulgxvu(xuhukrugei) = uojmvarrpa lzsivsvtky (xswrfshibr )
Positive
24 Oct 2022
Phase 2
97
ianrfkdohj(ywvgbjhsvp) = awqdmmoqdg swglpwyupi (xzlfimpbcj )
Positive
01 Feb 2022
dolutegravir/RPV
ianrfkdohj(ywvgbjhsvp) = fcljuiohoy swglpwyupi (xzlfimpbcj )
Phase 3
115
(Staff Study Participants)
lgaqvvvsva(tkabpftnxj) = ubhzzhwnvb vbdrwgsowj (liehmscmoh, 0.42)
-
10 Jan 2022
long-acting (LA)+CAB LA+Rilpivirine (RPV)
(Participants With HIV Infection)
wikrnocpnc(wzdrhqqeez) = chplyjvual heybxemaih (pkgtrsfxdf, 0.74)
Not Applicable
Maintenance
920
ettdwpbgyh(mijjlyfhye) = xbnicqkdkw tggskoctyw (fmazwgbnkz )
-
01 Jan 2022
Not Applicable
-
140
yecjfkehtx(lmznocxtfg) = jyoioklwdz wkrsabklkr (ububovpcpu )
-
01 Jan 2022
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