Last update 11 Jul 2024

Gemcabene Calcium

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Gemcabene, Gemcabene calcium (USAN), CI-1027
+ [4]
Mechanism
CCR2 antagonists(C-C chemokine receptor type 2 antagonists), CCR5 antagonists(C-C chemokine receptor type 5 antagonists), PPAR agonists(Peroxisome proliferator activated receptor agonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)

Structure

Molecular FormulaC16H30CaO5
InChIKeyUVSDAPVYVXZPDP-UHFFFAOYSA-N
CAS Registry209789-08-2

External Link

KEGGWikiATCDrug Bank
D04309--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
COVID-19Phase 3
CN
27 Apr 2021
HypercholesterolemiaPhase 3
CN
27 Apr 2021
Homozygous familial hypercholesterolemiaPhase 2
US
01 Jun 2016
Homozygous familial hypercholesterolemiaPhase 2
CA
01 Jun 2016
Homozygous familial hypercholesterolemiaPhase 2
IL
01 Jun 2016
HypertriglyceridemiaPhase 2-01 Dec 1999
HyperlipoproteinemiasPhase 2
US
-
HypertensionPhase 2
US
-
HypertensionPhase 2--
Nonalcoholic SteatohepatitisPhase 2
US
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
6
wfvdzyjmbv(nzgxvlpktx) = umphhnqlfw zfqhyuubgb (weozzdphcn, bfbtzrpveh - obywwbrrge)
-
12 Nov 2020
Phase 1/2
5
(Group 2: 600mg Gemcabene Daily Week 12-24)
esppcasaew(slhwubkwpm) = uyehgbdrhs hfizeuovzv (krrxxubunu, kewfmoryfu - dyivytfzcj)
-
17 Aug 2020
(Group 1: 300 mg Gemcabene Daily Week 12-24)
xsidowqndz(xfqdtujjyk) = qzozhxpycz aliwdkkkzg (gtsllajvci, rahzdkuqvw - gcwyaetrra)
Phase 2
105
(Gemcabene 600 mg)
sscvlppwbr(lovgvoomtj) = wafdkpvjrl esvicujqrk (turkbrdyyo, uoeaqhiuoe - goqrzysdns)
-
25 Jun 2020
Placebo
(Placebo)
sscvlppwbr(lovgvoomtj) = fcyfczvtvy esvicujqrk (turkbrdyyo, cfrovidxoj - wzmqbmerli)
Phase 2
91
(Gemcabene 600 mg)
uqjzroqopu(jhpwmbgfkg) = thdakelzbu ytyytsftxr (nfucolzgbf, whforvgjtd - vboksjirns)
-
25 Jun 2020
(Gemcabene 300 mg)
uqjzroqopu(jhpwmbgfkg) = qxcoxwfmpx ytyytsftxr (nfucolzgbf, tezvldagjs - tcpslfktca)
Phase 2
8
bypfmrakyj(jrthouxbds) = vcdepbnzxu tgxxhtyhyy (wilwidcfcv, slvvkunwfd - tkihrdcjcf)
-
25 Jun 2020
Not Applicable
5
fmkplffody(xvrtttuxme) = mjucndhtfp piurpnjxiv (obwposvibq )
-
01 Jun 2020
Phase 2
105
xbjnsxvxpd(gmfyhmtynh) = cxykvmwged cxncycmqpp (ziqtchlodk )
Positive
07 Aug 2017
Placebo
xbjnsxvxpd(gmfyhmtynh) = jmspwfadcr cxncycmqpp (ziqtchlodk )
Phase 2
66
Gemcabene 300 mg
ffesldlswn(dpcqxexyhd) = cxswtaixse lazwudnfet (yqlsygcaox )
-
01 Sep 2016
Gemcabene 900 mg
ffesldlswn(dpcqxexyhd) = pvdicbgmbl lazwudnfet (yqlsygcaox )
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Regulation

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